2012-06-05

liver-glucose reducer lowers inflammation

5.14: news.health/liver-glucose reducer lowers inflammation:
"Metformin's strong anti-inflammatory properties
by activating an enzyme called AMPK,
which in turn damps down
the activity of the protein NF-kappa B.
The inhibition of that suppresses the production of
inflammatory signaling molecules
-- cytokines and chemokines --
needed to initiate and sustain uveitis.
Uveitis causes 10 to 15 % of all blindness in the USA
and even higher proportions of blindness globally.
The only conventional treatment is steroid therapy,
which has serious side effects and cannot be used long-term.