Showing posts with label diabetes. Show all posts
Showing posts with label diabetes. Show all posts

2020-01-02

usefulness and availability of various forms of #ginger #health #diet

2019.12.28: health/diet/ginger/
usefulness and availability of various forms of ginger:
2020: summary:
. Dr.Sears and others who promote
ginger as an anti-inflammatory,
suggest you should use only the fresh root
whereas the cheapest is dried root.
. people who are buying fresh ginger online
warn it can easily get moldy in storage;
so, it may be safer to buy only in store.
. I would like to find frozen cubed ginger;
but I found research that shows
powdered ginger does offer some benefits;
and, certain high-heat ginger extracts
may have more benefits than fresh.

2017-05-18

dietary sources of AGEs #health #diet #cook

5.15: web.health/cook/dietary sources of AGEs:
summary:
. a doctor who wrote a healthy lifestyle book
says that sautéing is the best method for retaining nutrients;
but, sautéing involves browning the food,
and exposing fat to high heat.
. browning via heat is a Maillard_reaction:
Acrylamide, a possible human carcinogen
can be generated as a by-product of that.
. browning is related to AGEs
(Advanced_glycation_end-products)
however, I suprised to find
that compared to the diet I had supported,
browning vegetables is a relatively minor source
at least if very little oil is used;
because, foods high in even good fat
tend to contain high levels of AGEs
regardless of cooking method or being raw
-- relevant to a ketogenic (high-fat) diet.

J Am Diet Assoc. 2013:
Advanced Glycation End Products in Foods
and a Practical Guide to Their Reduction in the Diet.
"Modern diets are largely heat-processed
and as a result contain high levels of
advanced glycation end products (AGEs).
". grilling, broiling, roasting, searing, and frying
propagate and accelerate new AGE formation
[Crit Rev Food Sci Nutr. 1989,
J Am Diet Assoc. 2004]."
"In all food categories, exposure to
higher temperatures and lower moisture levels
coincided with higher dAGE levels
for equal weight of food
as compared to foods prepared at
lower temperatures or with more moisture.
Thus, frying, broiling, grilling, and roasting
yielded more dAGEs compared to
boiling, poaching, stewing, and steaming.
Microwaving 6 minutes or less
did not raise dAGE content to the same extent
as other dry heat cooking methods."
"... in animal studies, a reduction of
dietary AGE by 50% of usual intake
is associated with reduced levels of oxidative stress,
less deterioration of insulin sensitivity
and kidney function with age,
and longer life span [Am J Pathol. 2008:
Oral glycotoxins determine the effects of calorie restriction
on oxidant stress, age-related diseases, and lifespan.
"advanced glycation end products (AGEs) in the diet
correlates with serum AGE levels, oxidant stress,
organ dysfunction, and lifespan."]

. oils and nuts are AGE-rich, even in their
uncooked and minimally-processed forms;
for example, measuring just one of many AGEs,
we find in 100g:
grilled veg(broc,carrot,celery): 226 kU AGE;
-- a browning process yet not very toxic;
whereas,
raw cashew (steamed briefly) contains 6730;
-- compare to roasted: 9807;
so, most of the toxin is from the natural fat
not the roasting. compare also,
100 mL (3.38fl oz) extra virgin olive oil: 10,040.

protein is a moderate source too:

100g chicken boiled 1 hour: 1,123
-- or half that if using acidic solutions
such as lemon juice or vinegar marinades.

salmon canned: 917
salmon raw: 528
no mention of raw yolk but
100g yolk cooked 10 min is: 1193


2016-10-04

pregnancy brain

9.29: web.health/pregnancy/pregnancy brain:
summary:
"pregnancy brain" is loss of memory
or some sort of cognitive loss
that has not been detected by controlled studies,
yet there is solid indirect evidence.
. pregnancy causes insulin resistance,
and this causes the brain to use less fuel
which then results in less brain function
similar to what happens during Alzheimers.
. other sources of cognitive loss during pregnancy
include problems with sleep, and
having to reduce IQ-raising caffeine.
. magnesium enhances insulin sensitivity
(dark green leafies are the richest source).
. even though fish oil doesn't improve insulin sensitivity
it does enhance memory in some
and there is an FDA-approved form: Lovaza
(undistilled fish normally have too much mercury
for use during pregnancy).
Europe sells prescription R-lipoic acid that may help.

2014-11-02

big clue from #DownSyndrome prone to #Alzheimer's

10.25: news.health/alz/big clue from Down's syndrome prone to Alzheimer's:
. most people with Down's syndrome get Alzheimer's disease?
that makes sense because they are prone to obesity,
and tend to be intolerant of sugar,
(they then get spikes in blood sugar
that raises cholesterol that causes Alzheimer's disease).

2014-10-30

#obese more likely to die from #flu

10.21: web.health/hormonics/obese more likely to die from flu:
summary:
. the obese were more likely to get the H1N1 flu
and to subsequently die from it;
so, would that apply to any flu?
. usa's Advisory Committee on Immunization Practices
added morbid obesity to the list of conditions that
increase the risk of influenza-related complications,
including hospitalization and death .
. some say the obese should be urged to get flu vaccine,
while others claim vaccines may not work in the obese
because they are less like to mount an immune response .
. also, vaccines work surely only by herd immunity,
because, vaccines are not 100% effective,
so if you are obese surrounded by
thin people who don't get vaccinated,
getting a flu vaccine is not surely going to protect you from flu .
. vaccines aren't without risk,
so, it would be wise to minimize them .
. instead of flu vaccines,
we could vaccinate only the care providers
of those who stay home with the vulnerable
(infants and elderly)
and reduce the size of our obese population
by putting a huge tax on high-glycemic foods
and also on the high-fructose low-fiber foods .

2014-10-16

modern #medicine idol worship

10.11, 10.16: pol/healthcare/modern medicine idol worship:
. there are several meanings of "idol worship":
it was believed by the authors of the Bible
that each culture was ruled by its own god,
and that one's own god was the ruler of other gods
such that other gods were basically lifeless
and unable to work magic or bless their followers;
one's god required that certain commands be obeyed
and would provide rewards for doing so;
drugs were outlawed because they cheated the god
by taking rewards without doing the god's will .
. cheating the reward system is a form of idol worship;
because, it doesn't obey the culture's god
therefore it is worshiping some other culture
-- some non-god, an idol .

2014-02-07

new normal sugar doubles heart disease risk

7: news.health/new normal sugar doubles heart disease risk:
. sugar has been shrugged off as merely fattening;
but, it can also lead to cardiovascular disease
as well as many other chronic diseases,
including diabetes mellitus,
liver cirrhosis[from fructose in sugar],
and dementia [from cholesterol raised by sugar]
— all linked to metabolic perturbations involving
dyslipidemia, hypertension, and insulin resistance .
. in the latest study (JAMA Internal Medicine, Feb 3),
added sugars were defined as
those used in processed or prepared foods,
including sugar-sweetened beverages,
packaged cereals and breads, etc;
but not those that occur naturally
in fruit and vegetables.
. sugar counted for at least 25% of the calories
among 10% of the group;
that group had a 2.75 times greater risk
of cardiovascular disease mortality
compared to an sugar intake of less than 10%.

2013-12-18

. acetylcholinesterase inhibitors reduce #inflammation #Alzheimer's #MetabolicSyndrome

11.9: web.cook/hup/when is it needed?:
intro:
. in studying when huperzine (hup) is needed,
I'm wondering if the reason for it (confusion, forgetful)
was because I was depressed,
or otherwise in some condition that would be
assisted by the cheaper tryptophan .
. hup is an acetycholinesterase inhibitor;
so, is depression related to acetycholinesterase excess
or other causes of acetylcholine deficits ?
12.18: conclusion:
. there needs to be a balance between
dopaminergics and cholinergics;
increasing both equally
leads to good cognitive function;
and, there are several pitfalls
that are degrading one or the other,
including drugs and infections .
. the need for acetylcholinesterase inhibitor
is often due to low-grade infections
within the prostate or teeth,
that are leaking into the blood .

2013-12-03

prediabetes epidemic precedes #diabetes epidemic

10.1: news.health/prediabetes/defined and risk-assessed:
. prediabetes is defined as
 (FPG[fasting plasma glucose] 100–125 mg/dL
or a hemoglobin A1c level of 5.7%–6.4%)
--  higher than normal but not high enough to be
classified as diabetes.
In 2010, approximately 1/3 of U.S. 20+ year-olds
had prediabetes, (an estimated 79 million persons).
. during 2005–2006, only approximately 7%
of persons with prediabetes
were aware that they had prediabetes.
Each year, 11% of persons with prediabetes
who do not lose weight
and do not engage in  moderate physical activity
will progress to type 2 diabetes
during the average 3 years of follow-up.
Evidence-based lifestyle programs
that encourage dietary changes,
moderate-intensity physical activity,
and modest weight loss
can delay or prevent type 2 diabetes
in persons with prediabetes. 

2012-12-16

USA's pound-per-week hfcs = 8% diabetes rate

12.7: news.health/diabetes/
USA's pound-per-week hfcs = 8% diabetes rate:
High fructose consumption, higher diabetes:
. countries with lb-per-week hfcs diet
(high-fructose corn syrup)
had a diabetes rate of 8%,
which is only 1.3% higher than
countries not using hfcs .
Goran and Stanley Ulijaszek
of the University of Oxford
said of the 42 countries studied,
USA rate is 55 pounds per year;
Hungary: 47 lb per year.
. other high rates of hfcs include
Canada, South Korea, Japan and Mexico
Slovakia, Bulgaria, Belgium, Argentina,
. low-end hfcs users include:
Germany, Poland, Greece,
Portugal, Egypt, Finland and Serbia .
. amazingly, some regions still use
almost no hfcs! they include:
United Kingdom, Ireland, Australia,
France, Italy, Sweden, Denmark,
China, India, Uruguay.
--
Michael Goran, director of the
Childhood Obesity Research Center
and co-director of the
Diabetes and Obesity Research Institute
at the Keck School of Medicine at
University of Southern California .

2012-10-13

cure for some type-1 diabetes @JDRF_Tucson

10: web.health/type 1 diabetes/causes:
. what causes type 1?
the only widely acknowledged risk factor is heredetary
due to recessive gene (needs both parents).
. I seem to recall that this is one of those hereditary things
that could be controlled by environment ...
13: web:
J Endocrinol Invest. 2012 Sep 24:
rising incidence of type 1 diabetes in belgrade
children aged 0-14 in the period from 1982 to 2005:

Type- 1 diabetes is an autoimmune disease
in which both genetic and environmental factors
play a role in the etiology
. The average annual age adjusted incidence rate
of type-1 diabetes for Belgrade was 10.4/100,000
It was slightly higher in boys than in girls.
Over the 24 years incidence rates significantly increased
by 8.5% for boys and 3.0% for girls.
. the age of onset is not evenly spread over the age groups:
0-4, 5-9, and 10-14
-- it peaks during the natural rise of hormonal activity;
but only recently the rates are same for both sexes:
The age-specific annual incidence rates (per 100,000)
for the age groups 0-4, 5-9, and 10-14 were
5.5 (95% CI = 4.5-6.7),
11.9 (95% CI = 10.5-13.5) and
15.4 (95% CI = 13.8- 17.1), respectively.
The highest increase of incidence rate
was in the 5-9 age group.
The results obtained are in line with
data from other studies showing that
the incidence of type-1 diabetes has been increasing
in almost all populations worldwide.
natural hormone levels of children:
. estrogenic activity during femal infancy is quite high,
then it's supposed dip quite low until age 7 .
[. of course it should quite low in males
except around infancy? .]
Endocrine disruptors and type 1 diabetes: Is there a link?
. natural hormones can influence
the development of type 1 diabetes.
Gender differences are present
in type 1 (and type 2) diabetes,
and it is possible that sex hormones may influence
the risk of developing type 1 diabetes .
The incidence of type 1 diabetes in children
peaks at puberty,
a time of hormonal changes .
Pregnancy, another time of hormonal change,
can lead to gestational diabetes,
later followed by type 1 or 2 diabetes .
Psychological stress may be a risk factor;
and while the mechanism is unknown,
perhaps hormones released during stress
could play a role.
In addition, the hormone vitamin D
appears to be protective against it .
The role of taller height and excess weight
as risk factors for type 1 diabetes
may also involve hormones
We do not know, however, if xenoestrogens
contribute to the development of type 1 diabetes.
--
. if it's only slighly higher in males now,
and the rate increase for males
has been much higher than for females,
it seems that this disease is influenced by estrogens;
since during the last 25 years, due to rises in obesity,
children of both sexes have been getting
much more estrogen for that age;
but the proportional increase in estrogen
has been much higher for males .
. obesity also lowers male testosterone,
and there has been more exposure to xenoestrogens .

2012-09-28

corn syrup without fructose

7.7: pol/healthcare/corn syrup has no reason
without the unhealthy high fructose:

. even though fructose is
more expensive and unhealthier,
if fructose weren't added,
then corn syrup would not be sweet,
and then you'd have no reason to
add the corn syrup itself
other than it being a cheaper source of calories,
which gets: "( huh, why I am eating
so many empty calories anyway?
it doesn't even taster better! )

-- still, it would be just as filling, [9.27:
and then it would make you hungrier later;
so, I'm sure your food processors
would continue to add corn syrup to everything
even if it didn't have sweetening fructose .]

healthcare, christians, devils, & dollars

7.1: co.apt/pol/healthcare/
christians against obamacare are not middle class:. a born-again -furious child is chanting:
"( everyone needs to **** !! ),
[a word that can humorously mean both
{ practice birth control
, grumble incessantly}]

 . hearing this child has me kidding about
obamacare pressuring us to eat right;
but seriously, the problem with our economy
is the unfair christian,
demanding we have freedom of diet*
yet also demanding we subsidize
medicalization of bad diets
with emergency room care that is paid for
on the backs of middle class insurance payers
-- not paid by the poor and rich
where most christians come from .
* [9.27: to be fair:
. christians don't necessarily agree with
freedom of diet;
in fact, gluttony is a "(deadly 7) sin .]

7.5: co.apt/pol/healthcare/
how could they hate obamacare?:
. how could the masses hate obamacare?
do they know how the middle class
is getting gouged by mandatory e.r. care?
[9.27:
. most who still have jobs don't pay healthcare,
and that's exactly why fewer of us have jobs!
. after seeing the steeply rising trend of
healthcare benefits due to free e.r. care,
employers are outsourcing our jobs
to countries with more sensible policies .]

7.8: todo.web/pol/healthcare/obamacare assumes
everyone is getting healthcare through insurance!

. I thought the whole point of needing to use the ER,
is that doctor's and hospitals wouldn't let you pay
except through an insurance agency .

7.18: co.apt/healthcare/obamacare won't keep costs down:
. did you know we give $25 billion to diabetics?
 . just a five % decrease in diabetes
 could save an estimated $25 billion every year!
. that's a lot of money,
 and things like dialysis are inately expensive,
 but did you see how much our doctors cost?
 could we get them to take $40k  instead of $400k?
 we could hire 10times more of them,
 and give them a needed break . no way!
 obamacare couldn't even get them to
 agree to at least getting paid only
 relative to their worth:
 by how much they improved health
 rather than how many scripts they wrote .
 . you know why?
 because we are ***heads!
 [@] {arrogantly gluttonous, like drug fiends}
 . the doctors know that wellness starts with
 patients who listen to "(you need a diet)
 but they know patients ignore such advice
 and then demand a pill for their problems .
 -- how can you make any money
 getting paid to make the ***head well ?!

7.12: co.apt/pol/healthcare/
cheaper doctor is complicated
:

. finding a cheaper doctor is complicated:
they are not just healers but drug police;
and, high trust is expensive;
eg, suppose we get laborers to be doctors;
if they abuse drugs and lose their medical license
they just go back to being laborers;
but make doctors high,
and they will fall hard .
. another thing that raises cost is that they are
only getting paid if they share air with you?
that's not a very smart use of a rare resource:
they should be seeing patients by video
to do most of the interviews;
how often do you really need
a physical exam? consider this:
if doctors would just get to know
you, your habits, and listen
to your perceived problems,
they might have your problems solved
without having to share your germs .
[9.27:
. one way to lower the cost of interviews,
is to get college students to do the them;
they can write the doctor a report,
and the doctor can add to the report
after making an additional, shorter interview .
. also, you can call any time
to add things to your file,
and a nurse will do just that
and read back what was written .]

7.19: news.pol/healthcare/
Rush speechless about Canada's success:

. Rush's Limbaugh's agenda today
includes informing us that
while usa wealth slides,
canada's wealth has risen
-- now higher than usa's --
but he has no comment on this news?
nothing to say about gluttonous socialists, Rush?
. could it be that universal healthcare
was very good for Canadian business?!
ha!

7.26: news.pol/healthcare/
a doctor's take on care's high cost:

the people who profit from healthcare.
(more)
. there are a number of overfed cats in health care
who are being given all the food they meow for.
Here are a few examples:
# Drug companies:
If government and private insurers
were not paying for most of the drug costs,
we wouldn’t buy most medications
-- the full price is impossibly high.
Even many generics are over $100 per month.
Would you trade a $500K payment from gov
for a $20K check from the consumer?
No more than my cat would turn down
the third bowl of cat food.
# Hospitals:
Stents ‘R Us hospital in our town
just built a large cardiology wing
They did this using money from a procedure
that has not been shown
to prolong life or save lives.
# Ancillary Services:
Why does a CT scan in India
cost a fraction of the cost in the U.S.?
because they can be, due to third-party payors
who shield consumers from the cost .
They pass them on to the taxpayers
or raise the rates of the insurance policies.
It doesn’t hurt them to pay so much,
so they just keep feeding the kitty.
# Doctors:
Why do docs see so many patients
that they can’t offer good care,
and why do specialists take home
3/4 of a $million ? Because they can.
Someone keeps filling the bowl.

. the third-party payor system
hides the cost from the consumer
and gets us all used to the idea of
paying for all that cat food.
All of this money is thrown at care,
and what does it get us?
Does it get us better care?
Does it get us longer lives?
Does it get us happier patients,
or satisfied doctors?
-- Rob Lamberts, MD,
is an internal medicine-pediatrics physician
who blogs at More Musings (of a Distractible Kind).
7.26: co.apt/pol/healthcare/3rd-party payer syndrome
started with medicaid and nixon's cheap food program:

( reviewing 6.20: news.pol/purges/reaganomics/
republican nixon criticized for price-raising trade barriers)
. could anyone ruin this country more than nixon?
 trying to beat inflation with cheap food
he had devastated the food quality;
at the same time,
he had just started to give away
free medical (medicaid) to welfare cases;
and that is when people's health
went straight down the toilet
even as health care costs
were going straight up .
[. medicaid is what started that culture of
3rd-party payer syndrome
where they can ask for any price, because,
the person that actually pays is the taxpayer
who doesn't even see
how the money is being spent,
while the medicaid consumer
knows how it is spent,
but has no idea how much is spent .
. the politician apparently doesn't care
because the corporate profits translate into
both corporate taxes and campaign contributions .

2012-07-27

Dr.Williams questioning schiz' theory

6.24: news.psy/schiz/Dr.Williams is correct:
re:
By Paris Williams, PhD
. we still have no clear evidence that schizophrenia
and other related psychotic disorders
are the result of a diseased brain ...
anyone who takes a close look at the actual research
will simply not be able to honestly say otherwise.
And not only does the brain disease hypothesis
remain unsubstantiated,
it has been directly countered by
very well established findings
within the recovery research,
it has demonstrated itself to be
particularly harmful to those so diagnosed
(often leading to a self-fulfilling prophecy),
and is highly profitable to the
pharmaceutical and psychiatric industries
(which likely plays a major role in why it has remained
so deeply entrenched in society for so many years,
in spite of our inability to validate it).
review:
. I think Dr.Williams is correct,
although I didn't find his arguments compelling;
however, there is compelling evidence out there
(and he's got a book on it I bet is interesting).
. in fact, most psychiatrists secretly agree with him;

2012-07-16

high times for low carb

7.9..13: summary:
. A Calorie Is A Calorie theory
disproven again?
nobody was seriously positing
that all calories are equal;
what they were trying to do is
not offend the food marketers
or those who like the new modern diet .
. what they were say is:
"( so what if corn syrup is addictive:
can we treat consumers like adults?! )

. however, it's very interesting to hear
that low-carb diets raise cortisol
and C-reactive protein (measure of inflammation)]
more than low-glycemic diets !
-- esp'ly when most people will
misinterpret what that just said:
Atkins did not raise these!
Atkins dieters had very good cortisol levels
relative to the levels associated with heart disease
and Atkins will cut your CRP in half !

2012-06-10

ready for your sweet surprise?

5.14: co.fb#inst for respons' tech/health/
corn is not just bee killer:
What are your thoughts on this article?
GE corn & sick honey bees - what's the link?
| Pesticide Action Network
No farmer in their right mind wants to poison pollinators.
When I spoke with one Iowa corn farmer in January
and told him about the upcoming release of a Purdue study
confirming corn as a major
neonicotinoid exposure route for bees,
his face dropped with worn exasperation.
me:
I'm  sorry bees were harmed by gmo corn,
but we need hfcs (sweetsurprise.com)
to drive up glucose consumption
for more diabetes, cancer, senility, and heart disease
in order to fast-track healthcare technology .

5.14: co.fb#a4m (American-Academy-of-Anti-Aging-Medicine-A4M)/
health/cost is not just insurance pigginess:
Soda's Not-So-Sweet Side |
Anti-Aging Tip of the Day |
Worldhealth.net Anti-Aging News

More Americans now drink sugar-sweetened sodas,
sport drinks and fruit drinks daily,
and this increase in consumption
has led to greater incidences of
disease over the past decade
me:
another reason to send jobs overseas:
we can't possibly afford sugar nation's healthcare .

2012-05-01

link between alz and sugar may be cholesterol

4.13: news.health/alz/
 link between alz and sugar may be cholesterol:
4.13, 4.17: summary:
. when alzheimers was reported to be a clumping of protein
and related to diabetes,
I had assumed it was a glycation problem,
but here is evidence that cholesterol is implicated
by way of reducing leptin levels
which apparently is what prevents the formation of amyloid-β
and the occurrence of phosphorylated tau .
. the way it all ties together is that
cholesterol is elevated by sugary diet,
and a sugary diet is a leading cause of diabetes
(see the theory and results of an epi'study).

2012-04-03

desert diabetics at risk of fungal infection #HFCS #hormonics

4.2: web.health/diabetics at risk
of deadly, desert fungal infection:
summary:
. the Mayo clinic (in az's Phoenix suburbs)
has released a report of an invasive fungus,
Basidiobolus ranarum,
that is partial to deserts (Arizona and Saudi Arabia);
and, it grows tumor-like masses around the intestines;
but it's very rare, because it prefers diabetics,
other metabolic disorders, or the immune compromised .
. a systemic fungal infection that is partial to deserts?
that reminds of valley fever .
. I got very sore knees from valley fever in Tucson
after tilling the ground during the fungal infection's
favorite growth period: after a long-needed rain .
. Basidiobolus ranarum starts from ingesting the feces
of some animal whose intenstines usually contain it .
. the CDC had no clues as to how the very few victims
could have possibly ingested feces,
but they may not be aware of the desert's
ferocious dust storms:
they can dig deep for fresh feces,
and fling it into a breathing mouth or nose .

2012-03-31

#alzheimer's cured by anti-cancer drugs #health

3.21: news.health/alz/cured by anti-cancer drugs:

. epothilone D (EpoD) works like paclitaxel,
but it also crosses the blood-brain barrier,
bexarotene is another anti-cancer agent that
cures alzheimers in mice bred to develope alzheimers
or alz'-like symptoms .

. are these anti-cancer drugs working by controlling
sugar's ability to cross-link proteins?

Epothilones are Novel Anti-Tubulin Cytotoxic Agents .
Epothilones act via microtubule stabilization:
. after stabilization of microtubules,
the formation of the mitototic spindle is inhibited,
and the cell undergoes apoptosis.

uphs.upenn.edu's summary:
EpoD prevents cancer cell proliferation by
over-stabilizing specialized microtubules involved in the
separation of chromosomes during the process of cell division.
. in a mouse model of Alzheimer's disease (AD),
epothilone D (EpoD) is effective in
preventing further neurological damage
and improving cognitive performance:
. aged mice had memory deficits and a condition that resembles
the tangles formed by misfolded tau protein .
In nerve cells, tau normally stabilizes structures called microtubules,
the molecular railroad tracks upon which cellular cargo is transported.
Tangles may compromise microtubule stability
with resulting damage to nerve cells.

jneurosci.org's summary:
Neurodegenerative tau.opathies, such as Alzheimer's disease (AD),
are characterized by insoluble deposits of
hyper.phosphorylated tau protein within brain neurons.
Increased phosphorylation and decreased solubility
may diminish normal tau stabilization of microtubules (MTs).
EpoD treatment reduced axonal dystrophy
and increased axonal MT density
which led to improved cognitive performance.
Moreover, the EpoD-treated PS19 mice had
less forebrain tau pathology
and increased hippocampal neuronal integrity .

. another {anti-cancer, anti-alzheimer} coincidence
is that Bexarotene also cures both;
but appears to be doing so by a different route .
. while it controls cutaneous T-cell lymphoma by
activation of retinoid X receptors (RXRs);
it may be controlling alzheimer's amyloid plaque by
stimulating the expression of apolipoprotein E (ApoE)
which leads to intracellular clearance of β-Amyloid .

Apolipoprotein E (ApoE) :
. ApoE transports lipoproteins, fat-soluble vitamins, and cholesterol
into the lymph system and then into the blood.
It is essential for the normal catabolism of
triglyceride-rich lipoprotein constituents.
. found in the chylomicron and Intermediate-density lipoprotein
that binds to a specific receptor on liver cells and peripheral cells.
. it is suppressing T cell proliferation,
macrophage functioning regulation,
lipid antigen presentation facilitation (by CD1) to natural killer T cell
as well as modulation of inflammation and oxidation.
. ApoE also enhances proteolytic break-down of beta-amyloid,
both within and between cells;
but the E4 variant (isoform ApoE-ε4) is not very effective at this .
. carriers of 2 E4 alleles have 10 ... 30 times the risk of
developing AD by 75 years of age,
as compared to those not carrying any E4 alleles.

ApoE deficiency causes depleted myelin cholesterol;
statin therapy may result in Cholesterol Depletion;
both statins and ApoE deficiency can result in neuron failure
as can Alzheimer's disease .
The inhibition of liver-produced cholesterol is associated with
failure of cholesterol-rich lipid transport mechanisms
used by processes such as cell imports (endocytosis)
and cell exports (exocytosis).
. most substances important to cells are
large polar molecules that cannot pass through the
hydrophobic plasma or cell membrane;
therefore they rely on vesicles attaching to the membrane
to either import or export the reluctant molecules .
. cholesterol lowering drug can harm insulin function by
making pancreatic beta cells unable to export their insulin .
A retrospective analysis of a five year trial showed a
30% increase in the incidence of Diabetes
associated with a cholesterol reduction therapy .