2012-10-13

cure for some type-1 diabetes @JDRF_Tucson

10: web.health/type 1 diabetes/causes:
. what causes type 1?
the only widely acknowledged risk factor is heredetary
due to recessive gene (needs both parents).
. I seem to recall that this is one of those hereditary things
that could be controlled by environment ...
13: web:
J Endocrinol Invest. 2012 Sep 24:
rising incidence of type 1 diabetes in belgrade
children aged 0-14 in the period from 1982 to 2005:

Type- 1 diabetes is an autoimmune disease
in which both genetic and environmental factors
play a role in the etiology
. The average annual age adjusted incidence rate
of type-1 diabetes for Belgrade was 10.4/100,000
It was slightly higher in boys than in girls.
Over the 24 years incidence rates significantly increased
by 8.5% for boys and 3.0% for girls.
. the age of onset is not evenly spread over the age groups:
0-4, 5-9, and 10-14
-- it peaks during the natural rise of hormonal activity;
but only recently the rates are same for both sexes:
The age-specific annual incidence rates (per 100,000)
for the age groups 0-4, 5-9, and 10-14 were
5.5 (95% CI = 4.5-6.7),
11.9 (95% CI = 10.5-13.5) and
15.4 (95% CI = 13.8- 17.1), respectively.
The highest increase of incidence rate
was in the 5-9 age group.
The results obtained are in line with
data from other studies showing that
the incidence of type-1 diabetes has been increasing
in almost all populations worldwide.
natural hormone levels of children:
. estrogenic activity during femal infancy is quite high,
then it's supposed dip quite low until age 7 .
[. of course it should quite low in males
except around infancy? .]
Endocrine disruptors and type 1 diabetes: Is there a link?
. natural hormones can influence
the development of type 1 diabetes.
Gender differences are present
in type 1 (and type 2) diabetes,
and it is possible that sex hormones may influence
the risk of developing type 1 diabetes .
The incidence of type 1 diabetes in children
peaks at puberty,
a time of hormonal changes .
Pregnancy, another time of hormonal change,
can lead to gestational diabetes,
later followed by type 1 or 2 diabetes .
Psychological stress may be a risk factor;
and while the mechanism is unknown,
perhaps hormones released during stress
could play a role.
In addition, the hormone vitamin D
appears to be protective against it .
The role of taller height and excess weight
as risk factors for type 1 diabetes
may also involve hormones
We do not know, however, if xenoestrogens
contribute to the development of type 1 diabetes.
--
. if it's only slighly higher in males now,
and the rate increase for males
has been much higher than for females,
it seems that this disease is influenced by estrogens;
since during the last 25 years, due to rises in obesity,
children of both sexes have been getting
much more estrogen for that age;
but the proportional increase in estrogen
has been much higher for males .
. obesity also lowers male testosterone,
and there has been more exposure to xenoestrogens .