#9-11 #ControlledDemolition #asbestos#cancer#purges

11.21: mis.health/controlled demolitions for jet strikes 
release a lot of asbestos and other carcinogens:
. they still haven't solved the problem:
one white guy breezes through security,
and a jet goes into a tower,
that tower is likely to have the same
fire-suppressions systems as the WTC:
if the fire is small asbestos is on all the steel girders;
if the fire is huge then the controlled demolition happens,
and asbestos is all over the city .
11.28:
. who pushed the button on all those fire fighters?
. what button? terrorists did it .
. what about the 3rd building's collapse?
(full of survival gear, oxygen, and fuel -- collapsed
after it simply caught fire from falling debris?)
. cheer up,
how about a 3rd-degree terrorism war?

consumer advocacy on steroids! GoodGuide.com

11.19: news.health/
good guide .com/consumer advocacy on steroids!:
Moira speaks with UC Berkeley professor Dara O'Rourke,
founder of goodguide.com .
. now that brands are downgraded for not disclosing ingredients
more brands are changing their formulae for disclosability .

recovering from artificial joint surgery #med #osteo

bone will heal much faster if you
load up on vit'c and arginine;
I get mine cheap here: BeyondACenturyInc.

Kiva on-line all-star micro-lending facilitator

. I usually only give to disasters,
because that's when redcross calls;
but I'm so glad to find a micro-lending network on-line .
. I recently gave $25 to a similar wikipedia;
they are trying to spread into india
and other places in need of free education .

Kiva on-line all-star micro-lending facilitator
. Kiva  has Charity Navigator's highest rating

#thyroid optimization may save bone,vision #health

11.2 ..11.4: health/thyroid/
lifestyle choices that improve function:
summary:
low thyroid is very common:
. age-related hypo-thyroid
-- ie "(normal) TSH levels --
is as common as the many modern diseases,
and that may be more than a coincidence .
. there are ties to bone loss,
atrial fibrillation,
and blindness due to glaucoma
(you may be at increased risk if you are
nearsighted or hypo-thyroid).

. I will first explain how common low thyroid is,
and how it can be mistaken for hyper-thyroid
-- that's important to realize because
some are avoiding the iodine they need
under the assumption that they are hyper-thyroid
when, in fact,
both the low and high thyroid extremes
can have the same symptoms
of a rapid or erratic heart .

. the unprecedented rate of obesity starting in the 1980's
may be due to the combination of
not only replacing sugar with high-fructose corn syrup,
but also replacing the iodine in bakery goods
with bromides that actually inactivate
what little iodine you might already be getting !

#relocalization shoporganic.com

10.3: news.pol/relocalization/tucson/shoporganic.com:
. shoporganic is a local business
taking orders by internet .
. when they saw my order was large
(100lb beans, 4gal olive oil, 4lb seaweed)
they offered to split the shipping job with me:
. they brought it by car, and I did the unloading .
. that saved me $50+ ! .

#Solyndra loss #relocalization not go-#green

10.2: news.pol/obama/Solyndra's lost battle was
relocalization not go-green:
28 September 2011 Attacking Green Manufacturing

The Solyndra accusations are really just one part of
an ongoing conservative and oil-interests-funded
anti-green-manufacturing campaign drumbeat.
Long before Solyndra's bankruptcy
the Heritage Foundation was running stories like
2008's Green Jobs Are Con Jobs,
2009's The Green Job Myth Exposed,
and this year's Obama’s “Green Jobs” Pipe Dream,
Are “Green Jobs” the Answer?,
Are Green Jobs ‘Gone with the Wind’?...
Media Matters had previously exposed
the nature of this ongoing effort, in
Heritage Foundation Green Jobs Panel
- Bought and Paid For By ExxonMobil,
"( Instead of showcasing the views of
unbiased academics and economists,
the Heritage Foundation put forth a panel of
those financially connected to ExxonMobil.
... The ENTIRE PANEL Received Money From ExxonMobil. )

The Phony Solyndra Solar Scandal:

Even though Solyndra's investors lost out
our country retains the trained skilled employees,
the intellectual property, the innovators funded,
the suppliers, and the factory.
As components of a national effort to trigger a key strategic industry,
those are all still there and in the US.
The purpose of the government's involvement was to
help trigger the development of green-energy manufacturing
in the United States, not to help individual companies.
All these employees are trained,
all the researchers can take what they know
to other solar companies,
the IP is going to be sold
-- and it should be part of the conditions
that it be sold to an American company.
America's larger effort to nurture a solar-power industry
continues toward its goal
with assets enabled by this loan guarantee.

--[10.20:
. the problem with this argument is that
even if you believe in going solar
at the expense of oil and coal,
you are also trying to partially, weakly,
break out of the political pattern we are in right now
which is to do the manufacturing in 3rd-word countries .
. any manufacturing usa does (with its high-paid labor)
can only survive if usa already has a trade-protected
subsidized customer for those products .]

blogger.com feeds unreadable by some

9.13: mis.cyb/net.blogger.com/feeds unreadable by some:
. at blogger.com my feeds are now unreadable,
but only at duh's blog, not docs' .
. I have my feed being redirected to feedburner,
and, they have a feed validator page:
# feedvalidator.org (duh)
# feedvalidator.org (docs)
-- says it's a valid Atom 1.0 feed;
but has some protential problems ...
[... indeed, the feed was readable by Apple`safari
despite being unreadable by others
(firefox, feedburner, networkedblogs.com, ...).]

saved by backup with many snapshots

9.21: mis.cyb/fat32 sd card/corrupted:
(9.30: summary:
. only just months ago I started the policy of having
multiple backup snapshots instead of overwriting;
that turned out to be a life-saver, because,
to do overwrites safely,
you have to check every folder and file
to make sure none of them are corrupted .
)
. I tried saving html code to my sd card,
and it failed from both ko'edit and kompozer;
I thought it was a copy-protection trick ...
in fact, it's showing
everything in that folder is deleted!
log/psy now has zero items .

verifying corruption:
volume “SD2GB” ** /dev/disk2s1
** Phase 1 - Preparing FAT
** Phase 2 - Checking Directories
/PIM/2011/09 sep/0(cyb) has no clusters
/PIM/2011/09 sep/psy has no clusters
Marked 44 clusters as free
Free space in FSInfo block (141148) not correct (141192)
3306 files, 564768 KiB free (141192 clusters)

recovery by snapshot-backups:
oh, bak's are showing
those 2 folders have been empty for a while .
try a binary search:14, 17, 18 : ok?
18 14:17 is the last good;
cyb 15 9:37 (files: 15 18:48)
psy 15 18:42 (files 15 18:44)
the next is 19 18:58 -- both {psy, cyb} are missing .
cyb 19 17:50
psy 19 10:54 .

finding the cause:
. what was I doing when these changes got made?:
cyb 19 17:50
psy 19 10:54
. at 9.19.10:54 I was approaching mac,
but didn't do anything deliberate until 2 min later:

"( ... 10:56, gmail:0, log, ).

. maybe I jiggled the sd card, and lost the connection,
so it was like pulling it out without
giving the OS the warning it needed
to flush the caches and close the fs .
. at 9.19.17:50
I was about to break for some dictionary work;
1750 may have been at the time I started,
since I didn't give start-stop times for a 5-min job,
tho' it might have taken 10min

"( 17:50: this is the modify date of cyb.folder
getting corrupted . [9.21: found]
18:00?: used dictionary, )

. I remember being concerned that I was on a page
that did have ad's on it, but from the various browser logs,
{mac.safari, xu#main.vm, xu#wild.vm }
there was nothing around the time 19.18:00;
did I get ad's from mac.dictionary?
there were no ad's as I cycled through dict's history
but I think I was getting wikipedia from dictionary,
and then a link opened into safari .
. anyway,
pos.cyb/fs/sd card should be backup not primary:
. I'm working mostly from a vm,
so I keep my primary in a vmware shared folder,
and then backups happen with mac.timemachine .

dead hard drive revived

9.17: mis.cyb/usb.enclosure/dead drive needs deconnect:
. the backup drive is sputtering instead of on?
this is interesting because the reason I had stopped it,
was that the lightening was so fierce,
I was afraid to have my backup drive connected;
but here's another case where
being turned off is the end! ...
I think it had circuitry zapped that starts trouble,
but that trouble wouldn't show up until
unit was turned off
(I was using a UPS but didn't test it myself).
. anyway,
maybe the enclosure is zapped;
so, try a new drive: the enclosure is fine?
maybe it was the connections;
so, try the old drive again:
ok! my backup drive is humming .

Pixel Qi sensible displays

9.16: news.cyb/Pixel Qi sensible displays:
. when considering mobile devices,
remember first the display energy: Pixel Qi!
. it can be set to operate under transflective mode
(thus it needs lower backlight than normal LCDs)
and reflective mode (requires only ambient light)
--for eye-comfort, power-saving,
and visibility under bright ambient light.

Steve Jobs, Mac Plus, Unix, and finally iCloud

9.16: news.cyb/steve jobs/what's wiki's story?:

. Woz worked on supercomputers when Jobs and he met .
January 17, 2011,
. one and a half years after Jobs returned from his liver transplant,
Apple announced that he had been granted
a medical leave of absence.
As during his 2009 medical leave,
Apple announced that Tim Cook would run day-to-day operations
and that Jobs would continue to be involved in
major strategic decisions at the company.
Despite the leave, he made appearances at:

# the iPad 2 launch event (March 2),
The Apple A5 is a package on package (PoP) system-on-a-chip (SoC)
designed by Apple and manufactured by Samsung .
The A5 contains a dual-core ARM Cortex-A9 CPU
with NEON SIMD accelerator
and a dual core PowerVR SGX543MP2 GPU.
. iOS 5 (expected Oct. 12. 2011)
includes Notification Center, iMessage,
and an updated notifications system,
using a new "banner" style
instead of the originally used "alert" style.

# the WWDC keynote introducing iCloud (June 6)
. jobs revealed Apple's new cloud services offering,
iCloud. to be released in the fall of 2011
alongside iOS 5
and will be available with 5 gigabytes (GB) of storage
for 10 devices for free.
The service integrates with Lion and iOS applications
and syncs data between a user's iOS devices.
For example, calendar events created on a user's laptop
would be sent to their iPhone through iCloud.
Apps, books, documents, photos, and more
purchased or created on one device
will be shared with other devices.

August 24, 2011 Steve Jobs resigns as ceo .

#gov nutrition label for allergenic #gmo:

proj.pol/gmo/#gov nutrition label for allergenic #gmo:
Subject: Docket No. FDA-2011-P-0723
U.S. Food and Drug Administration
President Barack Obama
(emailed by gefoodlabels.org)
. I write in support of the Center for Food Safety's
Legal Petition to FDA to Require Labeling
of Genetically Engineered Foods
(Docket No. FDA-2011-P-0723).
FDA believes that GE foods are
“of the same or equal quality”?
how can random shifts in genetic code
not create inequal amounts of
random new proteins,
including allergens ?! this is appalling .
. if you put it on the label,
then people who think they have allergies
can try non-gm and see it was gm .
. that nutrition label needs an upgrade anyway:
you need the food's glycemic index,
glycemic load, and the amount of
any sugars that require liver processing,
especially fructose .

bible less a guide than a prediction

9.27: relig/bible/less a guide than a prediction:
. why can't people see the bible's
Noah's ark story? (prepare!)
the bible explains that
with the tower of Babel story:
lacking a universal language is the same as
not being able to communicate with others,
for example, there is no way to say
in any regional language:

"(if I don't try to out-breed you,
you should not feel the need to out breed me;
in our trust of this governance,
we can all grow wealthy ... and prepare .).

equal free #pol'speech #GetMoneyOut

10.1: news.pol/equal free #pol'speech #GetMoneyOut:
. there's a petition at GetMoneyOut for
a constitutional amendment based on this:

"( No person, corporation or business entity
of any type, domestic or foreign,
shall be allowed to contribute money, directly or indirectly,
to any candidate for Federal office
or to contribute money on behalf of or opposed to
any type of campaign for Federal office.
Notwithstanding any other provision of law,
campaign contributions to candidates for Federal office
shall not constitute speech of any kind
as guaranteed by the U.S. Constitution
or any amendment to the U.S. Constitution.
Congress shall set forth a federal holiday
for the purposes of voting for candidates for Federal office.)

. I signed this pretty easily,
and was asked to tweet the following:
"(I just signed a petition to #GetMoneyOut of politics
via @DylanRatigan )*
but while deciding how I would re-word it,
I realized I had no idea how they intended to
fund our federal election campaigns;
so, I researched and wrote this essay .
. the implied idea here is public funding
where every candidate has equal access to
eno' money to speak to the public;
and, run a debate through advertising .
*:
@DylanRatigan refers to The Dylan Ratigan Show on MSNBC

Fusion sharing external Linux drive #Mac #Vmware

9.22: cyb/mac/formats sharable with linux
9.30: intro:
. I have 2 machines: mac and linux,
and I want an external drive they can both use:
however last time I checked,
fusion couldn't allow a linux vm to
directly access a mac's external drive .
. if that is true, then I need some
mac drivers that access linux`ext{2,3,4} .
9.22: summary:
. it looks like the openware community
isn't really interested in ntfs support;
fat32 is sufficient if you minimize exposure:
having it mounted only for loading bak's,
and using that card only for a bak .
. I should use version control systems
to notice when corruptions have happened .

dual currency for accountability

9.19: news.pol/greek debt problem festers:
diane rehm/Eurozone Debt Crisis:
intro:
. the Eurozone Debt Crisis debate's main point
was that a few elite dogs ate the people's lunch
and then the elites idea of
making good on their bad loans
was selling off community-owned capital
and witholding labor-class benefits .
. this apparently has resulted in
class warfare:
the people are denying responsibility
for their elites .
. when foreign elites give loans that could
result in taking property from the people,
why would that transaction remain
between 2 elites ?
. you think our elites really have
a lid on civil war?
they certainly don't have a handle on
what they owe you!

Rush's dem's are hiding class warfare platform

9.19: co.apt/pol/Rush's dem's are hiding class warfare platform:

. Rush claims the dem's are "(hiding) the fact
that they are presenting the nation's problem
as class warfare? it's obvious!
that's the ticket they ran on;
and, in fact, it's the very reason
that the Rush conservatives will
routinely sneer about dem's being socialists:
that's what "(liberal) means!
how could they hide a class warfare platform?
that's what socialism is!

is it #underemployment or #overpopulation ? #pol

8.16: web.pol/purges/number of purged in usa:

intro:

. my definition of the practically purged
includes all forms of societal outcastings
whether it be to prisons or the streets .
. my definition of the homeless poor
are those in such poverty they can't even afford
a warm, safe car to sleep in
(insured, registered, and licensed),
and those having such meager social relations
that they would rather ask a charity shelter for bedding
than seek a place with family or friends:
this segment tripled from 1980 to 1990 .
. often the research on homelessness
will define the homeless as
not living in a house;
but 59% of those "(homeless) were car campers .
. even if cities have a war against car camping,
a person who has the income to do that
and finds somewhere to get away with it,
is not homeless in a warm, locked car .
[9.5:
. it is often conjectured that
many homeless are voluntarily unemployed;
but we should consider overpopulation:
if employees were always scarce,
we could easily find the money
to reserve the loner jobs for loners,
and the easy jobs for the slow;
we could be more generous with
subsidies for the challenged .
. most of a city's quality standard rules
(car-camping bans, maximums on number of
persons at one residence, ...)
are really more concerned with
suppressing overpopulation
than they are with actual safety .
. when you volunteer for employment in our economy,
you volunteer to do the work of 3 men
in order to pay for the wildly inflated
housing made scarce by overpopulation,
and pay taxes to support police & inspectors
that are primarily there just to
suppress overpopulation by
raising the cost of construction
(eg, building codes with min'size requirements,
or bans on factory-built homes)
and enforcing the inflated living standards
with bans on car-camping
(maximises property taxes paid by rents).
. you gotta problem finding a job to
pay for all this?
step across any of our bureaucratic lines
and you're easily purged to prison!
-- we're all about purging; because,
you're all about abundant-life free parenting .]

summary:

. out of 307M usa citizens, there are
2.3M prisoners
+ 0.124M chronic homeless .
-- thus our actual numbers of purgables
may be equal to our entire
year-1790 population! (3.9M) .
. our number of "corrected"
-- under correctional supervision --
is the size of our entire
year-1810 population! (7.2M) .

anti-#cancer #selenium-cysteine compounds

. this an update of my knol page:
health/cancer prevention/se-msc/
anti-cancer selenium-cysteine compounds:
Se-methylselenocysteine is the most valuable form of selenium

#relig #JC the illegitimate stoning

#relig #christianity YaHuWaH's Witness

#health gelatin makes meat #whole

#health #legume Dr Irene Darmadi-Blackberry #hormonics #longevity

#pol mentals and weiners and savages, oh my!

#Godboldo vs #antichrist #antipsychotic #childcare

#health #legume max bean zone diet #hormonics

8.10: news.health/zone/dr.sears
/whole beans are not zone protein

Dr.Sears`Mastering the zone, p10:
. bean protein digestion
is significantly incomplete
(in a typical nonanimal source of protein,
only 75 % of the protein is absorbed) .
[8.10:
. even if you did get
most of the bean's protein,
do you get the Zone diet's
glucagon-raising effect?
. the protein is raising glucagon
to spur the liver to produce brain fuel .]

. beans carry massive carb's;
so, consider them to be one of your carb's .
--[ perhaps he was just sympathising with
the popular conception that beans are
too gassy for a high-stress situation;
8.11: but,
if you got all your carb's from beans
(say, 80g of carb for one needing 60g protein),
then beans give 32g of protein;
and 70% of 32g absorbed is 24g
-- which is 40% of your 60g allotment!
just overlooked?! . he also says
never go over your protein allotment,
because it's a drug with consequences,
so, all considered, he might really mean
you should make beans just a side dish ?
8.27:
. in this article,
I find how to maximize the use of bean protein,
making sure the protein is balanced;
and determining how much is excreted with the fiber .
. finally I try to find what can be added
in order to raise glucogon without much insulin .]
8.29: summary:
. in a previous article on complete protein,
I had cited nutritiondata.com to show that
beans have complete protein
(important because beans = longevity);
however, growth optimization studies in rats
have shown that beans are short on
methionine, tryptophan, and, surprisingly,
could even use help with lysine
due to either the form or its required cooking .
. see bottom of this page, for a table of
amino acid percentages of various proteins .

missing the forest for the sugar trees

8.1: health/zone/Lustig/missing the forest for the sugar trees,

. this is a recap of the Dr.Lustig-coach debates .
. please note that while writing the following,
I was trying to understand a coach's view
without having any experience at being one;
if you'd like a good coach;
to learn how sugars can be your friend
see Dr.Lustig's debaters, Aragon and Hale:
. they have publications for not only
strength training and obesity control
but also how to do good health research:
#  Alan Aragon's Research Review
# Aragon . Girth Control:
The Science of Fat Loss & Muscle Gain
. Jamie Hale's publications:
# Knowledge and Nonsense,
  including Nutrition: Fact or Fiction
# MAXCONDITION
# Protein Essentials
# The Carbohydrate Files
. both appear on jpfitness.com's Nutrition forum:
# Hale has corrected Sugar Obesity myths
(notice the chiseled torso),
# Hale interviews Aragon,
# Aragon answers a question about subscriptions .

. in the debate with Dr.Lustig,
the coaches who defended simple sugars,
and esp'ly fructose,
were not sympathetic to Lustig's main point:
. not everyone has good coaches,
and they are getting caught in food abuse .
. it doesn't help a cocaine addict
to know that Dr.Freud could use responsibly;
what is most relevant here is
whether sugar is an abusable substance,
and can we do anything to curb abuse?

. the coaches certainly have a good reason
for supporting proper use of simple sugars:
there can be great gains in muscle-building
from the pulsing of insulin* and IGF
(insulin-like growth factor)
by properly applying the combination:
# whey or branched chain amino acids
(an insulin resistor and growth food)
# simple sugars (including both
the insulin-provoking glucose,
and the insulin-resisting fructose).
*(however, Aragon has reservations).

. some have even noted that proper pulsing
can increase testosterone levels
(testosterone can rise with insulin resistance),
while improper use that results in obesity
can lower testosterone
(converting it to estrogen).

. to get the proper effect from sugars
you need to be initially healthy,
with good insulin sensitivity,
assisted by peak resistance training,
or aerobic exercise,
and possibly fasting beforehand .

7.19: proper respect for context:
. chiseled fat-free bodybuilding
may depend on a chemistry
that can speed recovery without adding fat,
and that means refilling the liver's glycogen quickly
without having to worry about high glucose levels .
. for the most part, safe handling of glucose
means leaving it up to glycogen conversions,
and, on an empty liver (without glycogen)
fructose quickly provides this glycogen
because when empty,
the liver prefers converting fructose to
glycogen rather than to triglyceride .

. the general public is neither
pulsing their simple sugars properly
nor into peak-resistance exercising;
and, the sugar they use
is typically going straight to triglyceride!
. Dr.Lustig has linked abuse of sugar
to metabolic syndrome and obesity;
. Gary Taubes has linked cancer with
metabolic syndrome and obesity .

calories-in = calories-out myth

7.12:  health/calories in equals calories out myth:
. some promoters of the theory of
calories in equals calories out
explain that non-believers are citing
the myth of negative calorie foods:
that foods vary widely in the amount of
energy they require for digestion .
. while negative calorie foods is a myth
there are valid arguments against the
calories in equals calories out theory:
1: metabolic rates:
. some food vary your metabolic rate:
eg, mct oil is known to enhance thermogenesis;
whereas, some natural food toxins may
suppress metabolic rate;
eg, some potato preparations cause
insulin resistance .[7.31:
. I have only circumstantial evidence
against the splendid spud,
how would you explain its glycemic index
being higher than glucose itself?
my theory is that potato contains
an insulin resistor  that prevents the body
from clearing glucose as rapidly .
. it is known that damaged potato skins
can be toxic,
but I have no data on what in potato
could be an insulin resistor .]
 2: high-insulin mode:
. foods with a high glycemic index
are provoking excessive insulin release;
and high insulin levels can set your body
into fat preserving mode .
. when this mode is sustained by
regular use of a high-glycemic diet
fat is easy to put on, and hart to burn off,
even when you need more energy,
it will instead make you feel tired
to enforce the fat savings policy .
3: ketosis mode:
. Atkins also has well referenced case
that a carb-free, med-free diet
can promote a fat burning mode
that actually dumps calories out
with the feces and urine
as well as making body fat easier to burn .

. while other doctors debate the
healthiness of the Atkins diet,
they have no solid ref'backed counterarguments
to his zero-carb diet = fat burning mode theory
nor to his assertion that
obesity and high insulin mode
is far more dangerous than high fat diets
given the other stipulations of the Atkins diet
are heeded (high anti-oxidants, no peroxidzed oil,
few polyunsaturated fats except fishoil, ...).

. his diet does have medical complications
(kidney stress, ...)
and he does go against prior public medical advice
so, he puts other doctors in a bind
since their patients are now saying:
I need you to watch me do safely
what you warned me was unsafe .
. another complication is that
people cheat on diets,
and if you cheat on a high fat diet with
high-glycemic carbs,
that is a sure heart attack
because the carb's raise insulin,
while sat'fats cause insulin resistance,
thereby causing a very high insulin mode .

fructose | Chlorella is an antidote

7.24: news.health/fructose/Chlorella is an antidote:

. Chlorella is a nutritious
fresh water algae,
popular in Japan and Taiwan
that may reduce Insulin resistance
when used daily in several meals .
. the #1 cause of insulin resistance
is excessive fructose consumption,
according to Dr.Mercola,
referring to the modern diet high in
added fructose+glucose sweeteners .
. a rats-on-fructose-diet study showed
that chlorella undid some of the fructose's
insulin resistance .

safe-carb's Dr.Lustig

7.26: health/zone/safe-carb's Dr.Lustig

reincarnation of saint Atkins found!

. the spirit of Dr.atkins
was the same as Jesus Christ:
going against the established culture
to make big improvements for even the least of us .
. his particular achievement was to reveal
that, contrary to conventional medical advice,
a high fat diet was actually
safer for your heart than a
low-fat, normal-carb diet;
-- at least when you were
obese and insulin resistant --
because, among the insulin resistant
there is carb intolerance,
so that what seems like normal carb intake
is actually perpetuating
insulin resistance and high insulin
-- by far the highest risk factors
for heart disease;
he also revealed that for those who were
highly insulin resistant,
a zero-carb diet was essential to
getting back your insulin sensitivity,
and getting back into fat-burning mode .

frankenberry lives after golfcart nightmare

7.2: news.pol/obama/frankenberry lives after golfcart nightmare:
. on Whad'Ya Know? Live, (RealAudio)
Michael Feldman was asked about
frankenberry cereal being discontinued;
. wiki sources say the strawberry-flavored
corn and marshmallows cereal
is still in production .
. the myth was addressed at retroist.com:

"( Contrary to popular belief
Franken Berry and Boo Berry
have not been discontinued.
They are just not as popular as Count Chocula
so they get a more sporadic nationwide release.
Best time to look for them?
Halloween, of course.)

. similarly themed cereals that were discontinued
include:
# ('83) Fruit Brute:
Frosted fruit-flavored cereal
with lime flavored marshmallows .
with a Werewolf Mascot .
# ('93) Fruity Yummy Mummy:
Frosted fruit-flavored cereal
with vanilla-flavored marshmallows .
. other such cereals still in production
include Count Chocula, and Boo Berry .

. Feldman has been attacked by 
anti-liberals on his show
and our most popular breakfast berry
is the nearly-obama-colored blueberry,
so, it occured to me this was a joke about
Obama's serial presidency plans
 being discontinued .

. in the same program,
Feldman had a political routine where
callers were asked if they had seen any
congressmen on the road .
. the final entry of that joke sequence
was that Obama and his VP
 were seen on a golfcart
with a sign that read "(fool and tool) .

. the golf cart joke may refer to a ridiculed
tax rebate for road-worthy golfcarts .
. that was back in 2009,
but is painfully relevant now
as a republican congress threatens to
deny raising the debt limit ceiling .
. the golf cart was news again June 18
when the top leaders of both parties
had a round of golf at a time when the hot policy
included the debt ceiling
and the Libya actions that Congress was against .

lifestyle choices for blindness prevention

• 
  
  • intro
    
    • # high-fiber vs high-carb':
    • # good fat vs bad fat:
    • # moderate fat vs high or low fat:
    • # peak resistance training
  • foods that prevent macular degeneration:
    
    • sources of zeaxanthin:
    • == high-density zeaxanthin sources ==
    • == moderate-density zeaxanthin sources ==
    • == low-zeaxanthins relative to lutein ==
    • ### top lutein+zeaxanthin foods at usda database: ###
    • ### Lutein content of best sources ##
    • #### lycopene content of best sources ####
  • supp's that may reduce blindness risk
  • medications that increase blindness risk
    
    • pills vs eyes 2008:
      
      • Angle-closure glaucoma:
      • Cataracts
      • Retinal Abnormalities
      • Optic Nerve Diseases
    • sleeping aids
    • anti-aggressives

intro

6.21: intro:
. 48% of world blindness is attributed to
Age-related cataract;
. the term "(aging) actually refers to
an increasing amount of metabolic disorder
including diabetes, hypertension, and hypothyroidism .
extent of cataract formation by age range:
42% affected by ages of 52 to 64,
60% affected by ages 65 and 74,
91% affected by ages 75 and 85 .

[. macular degeneration is the leading cause of
age-related blindness .
. there are some dietary factors that may prevent this;
but the most important contributary causes
are the same as for cataracts:
one's lifestyle or medication choices
can affect the rate of aging .
. for example,
at the same time there were cataracts [6.29:
within my circle of friends ]
there was also use of Dalmane,
a benzodiazepine sleeping medication
that is known to increase the likelihood of cataract .
. children and other behaviors are increasingly being
medicated with tranquilizers and other psychotropics
that contribute to the big 3 metabolic disorders:
diabetes, hypertension, and hypothyroidism .

. risk factors are [6.29:
proportional to one's lifetime dose,
and dose variations for ]
sunlight, smoking, alcohol, other medications .
. dietary protective factors
include:

# high-fiber vs high-carb':

[6.29: ie, high-carb diets are good only when
much of the carb is fiber,
and none of it has a high glycemic index .]

# good fat vs bad fat:

 [6.29:  mono'fats are good fats for energy;
other fats are essential for body maintenance;
use only low doses of fish-related poly'fats,
and even lower doses of non-fish poly'fats;
sat'fats cause carb'intolerance,
so they don't mix with a glycemic diet .]

# moderate fat vs high or low fat:

[6.29: mono'fats (olive oil, almonds, hazels)
are a safe source of energy;
but fats are a special source of
carcinogenic pollutants and mold toxins;
moreover,
low calorie is safer than high calorie .]

# peak resistance training

[6.29: short bursts of moving heavy things
can increase insulin sensitivity,
and reduce carb'intolerance .]

Ann Epidemiol. 1996 Jan; 6(1):41-6.

. this study indicates that diet
plays a considerable role in
the risk of [needing and being eligible for]
cataract extraction
in at least a certain Italian population,
with a protective action played by
some vegetables, fruit, calcium, folic acid,and vitamin E,
and an increased risk
associated with elevated salt and fat intake [6.29:
-- this could have been a measure of
where these Italians were getting their
extra doses of salt and fat:
the usual culprit is luncheon meat
-- known to promote diabetes by
mixing sugar with the meat .]
. a significant inverse trend in risk,
were found for intake of
meat (OR 0.6, 95% CI 0.4 to 0.9),
cheese (OR 0.7, 95% CI 0.5 to 1.0),
[implied a more low-carb' diet?
the atkins effect .
6.19: ie,
not necessarily an endorsement
of cheese ! ]
cruciferae (OR 0.5, 95% CI 0.3 to 0.8),
spinach (OR 0.6, 95% CI 0.4 to 0.9),
tomatoes (OR 0.5, 95% CI 0.4 to 0.8),
peppers (OR 0.7, 95% CI 0.4 to 1.1),
citrus fruit (OR 0.5, 95% CI 0.2 to 1.3),
and melon (OR 0.5, 95% CI 0.4 to 0.8).

. a significant increase in risk
was found for
the highest intake of
(compared to the lowest intake)
butter (OR 2.8, 95% CI 1.2 to 6.4),
[6.29: apparently Italian cheese is
not a significant source of butter ? ]
total fat(OR 1.8, 95% CI 1.2 to 2.8),
[ie, sat'fats vs oils]
salt (OR 2.4, 95% CI 1.4 to 4.0)
[luncheon meats vs fresh meats]

. a significant increase in risk
was found for consumption of
oil other than olive oil
[mono'fats vs poly'fats]
(OR 1.6, 95% CI 1.1 to 2.2).

Among micronutrients,
lower ORs for cataract extraction
(highest quintile of intake compared to the lowest)
were found for intake of
calcium (OR 0.5, 95% CI 0.3 to 0.8),
folic acid (OR 0.4, 95% CI 0.2 to 0.7),
and vitamin E (OR 0.5, 95% CI 0.3 to 1.0),
[this may have more to do with
the foods that provided these micronutrients]

. intakes of
methionine, retinol, beta-carotene,
and vitamins A, C, and D
were not associated with cataract risk .

foods that prevent macular degeneration:

6.20:
. being low on zeaxanthin or lutein
is associated with risk of amd
(age-related macular degeneration);
it's easy to get lutein
-- dark green leafy vegetables --
but zeaxanthin is a bit less common;
so this section has a list of
zeaxanthin-specific foods
sorted by density .
. some other carotenoids were included
for their anti-cancer importance .

. this research confirms previous reports
that the primary eyecare superfoods
are egg yolks for zeaxanthin
and dark green leafies for lutein .

. corn and sweet citrus are high in zeaxanthin
but not so relative to either
corn's glycemic and inflammation indices,
or citrus's fructose levels
(a source of liver-produced triglycerides).
--
. I noticed huge variations among 2 databases:
eg, the lab that gave percentages of zeaxanthins
differed wildly from percentages implied by
usda's nutrient density data;
so, consider this to be a very rough estimate
for where your eyecare diet should be .

sources of zeaxanthin:

. many texts give levels of carotenoids in foods;
here is a source that tells
what percentage of the carotenoids there are
for these famous varieties:
{zeaxanthins, lutein, lycopenes, beta-carotenes}
(as a percentage when counting by molecules,
not a percentage by weight):

Fruits and vegetables that are sources for lutein and zeaxanthin:
the macular pigment in human eyes
O. Sommerburg, J. Keunen, A. Bird, and F. J G M van Kuijk
Br J Ophthalmol. 1998 August; 82(8): 907–910.

todo:

see the articles that cited that one:
# elders respond postively to egg consumption
# controversial role of lutein and zeaxanthin
in protecting against age-related macular degeneration:

. most of the dark green leafy vegetables,
have 15-47% of their carotenoids as lutein,
but very little zeaxanthin (0-3%)

[6.20:
... not many were tested, however ...

. the reason dark green leafies may still
help to avoid macular degeneration
despite being short zeaxanthin,
is that this disease depends a lot on
metabolic disorder and clogged arteries
whereas dark green foods have a lot of
the magnesium from chlorophyll
that can support the insulin sensitivity
that prevents metabolic disorder;
and, they are also high in the
vitamin K that can hold calcium in bones
to prevent calcium-clogged arteries
(a major cause of irreversable circulation loss).

. this list is sorted by a food's
zeaxanthin density, which is a product of
both the ratio of zeaxanthin to other carotenoids,
and the total carotenoid density .
. even though corn appears to have
great values for zeaxanthins,
high-glycemic foods like corn
can bring down HDL; and ]

while most of the absorbed carotenoid
is carried in LDL,
53% of the (lutein, zeaxanthins) group
is carried by HDL .

[6.21:
. another source that conflicted with my first was:

Lutein and Zeaxanthin Scientific Review:
for instance, they claimed cooked spinach had
0.2 mg Zeaxanthin rather than 0.0000 .
. they gave a list of zeaxanthins per 100g servings,
which I have appearing like this:
[corn 0.5mg Z per 100g] -- with a Z added;
if the Z is not there, then it refers to
combined {zeaxanthins, lutein} amounts .]

== high-density zeaxanthin sources ==

ratio's of
zeaxanthins,
lutein,
beta-carotene,
and lycopenes(omitted if zero):
[plus amounts of (zeaxanthins, lutein) per serving]

35,54,0 Egg yolk [0.5 mg per 2 eggs (100g)][6.29:
^-- that number(35) mean 35% of the 0.5mg
is the rare zeaxanthins form ]
-- selenium 17.2 mcg (varies widely)

[Persimmons, Japanese, raw 0.49 Z per 100g]
[Spinach, raw 0.33 Z per 100g]
37,8,21 orange pepper [1.6mg Z per 100g]
2,27,11 brussel sprouts, [2.389mg per 155g]
3,36,12 green pepper [0.586 mg per 136 g]
5,47,5 zucchini squash [1.15mg per 100g of
... Squash, summer, zucchini, includes skin, boiled,]
3,27,0 scallions, [1.137mg per 100g of
. . . Onions, spring or scallions (tops and bulb).]
3,22,5 green beans, [0.64mg per 100g of
. . Beans, snap, green, raw, 0.44mg canned]
2,32,0,1 celery [0.494 mg per 150 g]
[Turnip greens, cooked 0.27 Z per 100g]
[Collard greens, cooked 0.27 Z per 100g]
[Lettuce. cos or romaine, raw 0.19 Z per 100g]
[Spinach, cooked 0.18 Z per 100g]
[Kale, cooked 0.17 Z per 100g]

== moderate-density zeaxanthin sources ==

ratio's of zeaxanthins, lutein, beta-carotene,
and lycopenes(omitted if zero):
[plus amounts of (zeaxanthins, lutein) per serving]

25,60,0 corn [0.19 mg per 28g --
. . a safe 100-colorie dose for this inflammatory grain]
http://nutritiondata.self.com/facts/cereal-grains-and-pasta/5687/2
[Tangerine, mandarin 0.14 Z per 100g]
20,15,8 orange juice [0.10mg per orange(86g)]
. 15,7,11,11 orange [0.17mg per peeled(131 g)]
. 6,6,48 nectarine [0.185mg per peeled(142g)]
18,17,48 honeydew melon [0.027 mg per 100g]
16,2,20,6 mango [0.023 mg per 100g]
10,43,16,5 red seedless grapes [0.072 mg per 100g of
. . . red or green seedless has ]
. 7,25,7 green grapes
. 4,33,6 red grapes [0.064mg per 100g of
. . Grapes, muscadine(has seeds).]
8,5,50 peach [0.089 mg per 98g]
4,38,4 cucumber [0.07mg per veg(301g)]

2,11,16,57 tomato juice (needs heat & oil)
0,6,12,82 tomato whole [0.08mg per 100g
. . but the lycopene is 9.66mg ]
1,19,17,13 apple(red delicious) [0.029mg per 100g of
. . . Apples, raw, with skin ]

== low-zeaxanthins relative to lutein ==

ratio's of lutein, beta-carotene,
and lycopenes(omitted if zero):
-- these are among the many examples of
high-lutein foods that have no zeaxanthins .
49,21 pumpkin
47,16,4 spinach
44,9 yellow squash
41,5 pea
37,0 butternut squash
22,27 brocolli
16,0 lettuce
12,0 yellow pepper
7,3 red pepper [0.05 mg per 100g]
2,55 carrots
1,87,3 cantaloupe

### top lutein+zeaxanthin foods at usda database: ###

. nutrients per food .
. foods rich in a given nutrient .
### Lutein + zeaxanthin ###
[. this data(pdf) was merged with the
zeaxanthin table (above) ]

### Lutein content of best sources ##

(extracted from a pdf)
Spinach, frozen, boiled, 130g 25.606 mg
Spinach, canned, 214 g 22.631 mg
-- Magnesium 87 mg per mg
-- Vitamin K (phylloquinone) mcg 493 per 100g
Kale, frozen, boiled, 130g 25.606 mg
Kale, boiled, 130 g 23.720 mg
-- Vitamin K (phylloquinone)      mcg 817 per 100g
-- Magnesium 18 mg per mg
Turnip greens, frozen, boiled, 164 g 19.541 mg
Collards, frozen, boiled, 170 g 18.527 mg
Collards, boiled, 190 g 14.619 mg
-- Vitamin K (phylloquinone)      mcg 440 per 100g
-- Magnesium 20 mg per mg
Turnip greens, boiled, 144 g 12.154 mg
Dandelion greens, boiled, 105g 9.616 mg
Mustard greens, boiled, 140g 8.347 mg
Squash, summer, boiled, 180 g 4.048mg
Peas, green, frozen, boiled, 360 g 3.840 mg
Peas, edible-podded, frozen, boiled, 160g 1.429 mg
Peas, edible-podded, boiled, 160 g 1.123 mg
Squash, winter, baked, 205g 2.901 mg
Beet greens, boiled, 144g 2.619mg
Pumpkin, boiled, 245 g 2.484 mg
Squash, summer, raw 113g 2.401 mg
Broccoli, frozen, boiled, 184g 2.015 mg
Broccoli, boiled, 156 g 1.685 mg
Broccoli, raw 88 g 1.235 mg
Lettuce, raw 1 head 163 g 1.993 mg
-- butterhead (includes boston and bibb types),
Lettuce, raw 1 head 539 g 1.493 mg
Lettuce, cos or romaine, 56 g 1.295 mg
-- iceberg (includes crisphead types),
Lettuce, green leaf, raw 56 g 0.969 mg
Asparagus, frozen, boiled, 180 g 1.112 mg
Carrots, boiled, 156 g 1.072 mg
Leeks, (bulb and lower leaf-portion), boiled,  104 g 0.962 mg
Asparagus, boiled, 60 g 0.463 mg
Asparagus, canned, 72 g 0.454 mg
Pepper, sweet, red, raw 119 g 0.061 mg

#### lycopene content of best sources ####

Watermelon, raw 6.889 mg per 152 g
Tomatoes, red, ripe, canned, 6.641 mg per 240 g
Tomatoes, red, ripe, raw, 4.631 mg per 180 g
Papayas, raw 2.559 mg per 140 g
grapefruit 1.745 mg per 123 g

supp's that may reduce blindness risk

(from macular degeneration and cataracts)

5 mg zeaxanthin,
10 mg lutein:
800 mg magnesium,
400 mg potassium
Lutein and zeaxanthin offer protect from both
age-related macular degeneration and cataracts .
. Carotenoids are fat-soluble,
and are therefore absorbed with oil;
eg, after steam-sterilizing the greens,
puree them with olive oil .
. leafy greens are a good source of
lutein, magnesium, and potassium;
esp'ly spinach . green = magnesium .
. supp's are economical .

0.5 ... 3.0 mg Melatonin at bedtime
400 mcg selenium
600 mg N-Acetyl-Cysteine or eggs
210 .. 420 mg R-ala (alpha lipoic acid)

. melatonin stimulates glutathione production;
it is a potent inhibitor of cataracts;
proven in animal models .
Melatonin production slows after age 40,
but by age 60 virtually no melatonin is produced
at a time when most cataracts develop.
. 3 mg of mel at bedtime in elders with AMD
prevented further vision loss (Yi 2005).

[6.21:
. melatonin needs selenium and cysteine to work;
egg yolk has 250mg of cysteine;
but it's not as stable as N-acetyl-cysteine;
so, it's recommended it be taken with vit'C,
and other anti-oxidants found in a normal diet,
along with the r-ala .]

. ala prevents cataract by
protecting glutathione synthesis.
. in animal models it reduced cataract by 40%
and protected the lens from losing
vitamins C, E, and glutathione.
. vitamin C is a first-line neutralizer of radical;
it is then recycled by glutathione .

. Selenium works with alpha-lipoic acid
to increase cellular concentrations of glutathione,
. Low plasma levels of vitamin E
increase the risk of lens opacities.

[. the Vitamin Book said vit'E's job was

facilitating the transport of selenium;
there have been contradictory results from
trying to megadose vit'E as an anti-oxidant .]

. cysteine is a component of glutathione;
A combination of diallyl disulfide
(a major organosulfide in garlic oil)
and N-acetyl-cysteine (NAC)
completely prevented cataract development in animals.

50 .. 150 mg riboflavin:

Riboflavin reduces oxidized glutathione;
it is a precursor FADH
(reduced flavin adenine dinucleotide)
which is used by glutathione reductase,
to reduce and activate glutathione;
it makes glutathione available for the enzyme
glutathione-selenium peroxidase,
which neutralizes peroxide free radicals .

250 mg Inositol nicotinate:

. occurs in high concentrations in the lens.
Inositol quenches reactive oxygen .

2.5 mg folic acid
50 mg B6 [6.29: that's a high dose; addicting?]
1 mg B12

. B-6 prevents free-radicals by
properly metabolizing homocysteine
and is required for absorption of vitamin B12,
and proper synthesis of nucleic acids.
. . low levels of the B vitamins that are
critical to the metabolism of homocysteine),
will result in elevated levels of homocysteine,
which is a risk factor for both AMD and
other cardiovascular diseases .
. supplementing with folic acid, B6, and B12
can significantly reduce the risk of AMD
in adults with high homocysteine (Christen 2009).

100-200 mg CoQ10;
500mg acetyl-L-carnitine
+ 500mg arginine base
[= acetyl-L-carnitine arginate? 6.29:
-- perhaps a patents issue]:

. Mitochondrial dysfunction can result in
reactive oxygen species
linked to both cataracts
and macular degeneration;
a combination of CoQ10, acetyl-L-carnitine,
and proper diet,
improved mitochondrial function .
Acetyl-L-carnitine can reduce cataract risk
by acetylating potential glycation sites
that would otherwise cloud lens crystallins .

DHEA

. abnormally low in patients with AMD (Bucolo 2005).
DHEA also has been shown to protect the eyes against
oxidative damage (Tamer 2007).

[6.21:
. do not take this hormone orally;
it can be very effective nasally
in micronized form 5..10mg;
or blenderize dhea into a progesterone cream .
. exercise can raise dhea,
as can lowering cortisol .

[6.29: my cortisol-lowering diet module is this:]
a low carb diet; and,
arginine+lysine several times:
1 tsp 3 times per day;
and 6tsp at night .]

120 mg Gingko biloba
100 mg bilberry

Gingko biloba has anti-cataract potential;
Bilberry, a proanthocyanidin,
Gingko biloba and bilberry may restore
microcapillary circulation.
. bilberry contains Anthocyanidins
and Cyanidin-3-Glucoside (C3G);
. anthocyanidins may prevent leakage from capillaries,
prevalent in neovascular AMD.
Studies also show that bilberry increases
oxidative stress defense mechanisms in the eyes (Milbury 2007).
C3G fights inflammation by
inhibiting inducible nitric oxide synthase (iNOS),
C3G increases cytokine adiponectin
[. helps burn energy instead of letting it
raise sugar levels and increase fat .]
C3G may be protect against Alzheimer’s
[. that wouldn't be surprising,
if it does reduce sugar spiking .]
C3G helps to induce apoptosis
in a number of human cancer lines .
Bioflavonoids are powerful inhibitors of
the enzyme aldose reductase.
If aldose reductase activity falls,
sorbitol is not synthesized.
This reduces the accumulation of
water in the lens.
The bioflavonoids quercetin, myrcetin,
and kaempferol (from limes)
specifically inhibit diabetic cataracts.
Gingko is a widely used flavonoid that
maintains microcirculation to the eye
and inhibits free radicals.

500-1000 mg carnosine

inhibits formation of AGEs
(advanced glycation end products)

Eye drops containing N-acetyl-L-carnosine

can delay vision senescence in humans:
effective in 100% of primary senile cataract cases
and 80% of mature senile cataract cases.
N-acetyl-L-carnosine eye drops are approved for
human use in Russia for the treatment of many eye diseases.
Brite Eyes II contains
1% N-acetyl-L-carnosine
L-Carnosine is an anti-glycation agent;
Topically applied N-acetyl-carnosine
prevented light-induced DNA strand breaks
and repaired damaged DNA strands (Specht 2000),
and has improved visual acuity,
glare and lens opacification
in animals and humans with advanced cataracts
(Williams 2006, Babizhayez 2009).

Phil Micans PharmB, Vice President, IAS Group:
Dr. Mark Babizhayev:

. the application of L-carnosine for the treatment of
human cataracts is misleading.
This is because L-carnosine readily becomes a substrate for
the activity of natural peptidases (i.e. carnosinase)
in the aqueous humor.
So much so, that there is
no sign of L-carnosine in the aqueous humor
within 15 minutes after instillation.
Furthermore,
I consider that L-carnosine eye-drops
may even be harmful for eyes because
it gradually releases histamine,
which, located as it would be
in the presence of the eye-lens
is a very toxic agent.
However, NAC eye-drops are resistant to
hydrolysis with natural carnosinase.
Therefore, NAC is the only currently known agent
which reverses and prevents human cataracts.

update understanding of cataract:
NewsRx.com 01-29-10/Study data from M.A. Babizhayev and colleagues

"The antioxidant activity of L-carnosine (beta-alanyl-L-histidine,
bioactivated in ocular tissues)
versus N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine,
ocular-targeted small dipeptide molecules)
was studied in aqueous solution
and in a lipid environment,
employing liposomes as a model of lipid membranes.
Reactive oxygen species (ROS) were generated by an
iron/ascorbate promoter system for induction of lipid peroxidation (LPO),"
investigators in Russia report .

"L-carnosine, which is stabilized from enzymatic hydrolysis,
operates as a universal aldehyde and ROS scavenger
in both aqueous and lipid environments
and is effective at preventing ROS-induced damage
to biomolecules.
Second-generation carnosine analogs bearing the
histidyl-hydrazide moiety
were synthesized and tested versus L-camosine
for their ability to reverse the glycation process,
also known as the Maillard reaction,
and reverse the stable intermolecular cross-links,
monitored in the glucose-ethylamine Schiff base model,
ultimately resulting in the formation of
the advanced glycation end products (AGES)
from nonenzymatic glycation,
accumulating in numerous body tissues and fluids.
The obtained data demonstrate the transglycation properties
of the ophthalmically stabilized L-camosine
and L-carnosine histidyl-hydrazide derivatives tested
and can be used to decrease or predict the occurrence of
long-term complications of AGE formation
and improve therapeutically the quality of vision
and length of life for diabetes mellitus patients
and survivors with early aging.
Scientists at Innovative Vision Products, Inc. (IVP),
developed lubricant eyedrops designed as a
sustained-release 1% N-acetylcarnosine prodrug of L-camosine.
The eyedrops contain a mucoadhesive cellulose-based compound
combined with corneal absorption promoters
and glycerine in a drug-delivery system.
Anti-aging therapeutics with the
eyedrop formula including N-acetylcarnosine
showed efficacy in the nonsurgical treatment of
age-related cataracts for enrolled participants
in the prospective, randomized, double-masked,
placebo-controlled crossover clinical trial
after controlling for age, gender, and daily activities.
In a cohort in excess of 50,500 various patients
seeking cutting-edge medical care,
the N-acetylcamosine topical eyedrops target therapy
was demonstrated to have significant efficacy, safety,
and good tolerability for the prevention and treatment of
visual impairment in this older population
with relatively stable patterns of causes
for blindness and visual impairment.
Overall, accumulated study data demonstrate that
the IVP-designed new vision-saving drugs,
including N-acetylcarnosine eyedrops,
promote health vision and prevent vision disability from
senile cataracts, primary open-angle glaucoma,
age-related macular degeneration, diabetic retinopathy,
and aging.
N-acetylcarnosine eyedrop therapy is the crown jewel of the
anti-aging medical movement
and revolutionizes early detection, treatment,
and rejuvenation of aging-related eye-disabling disorders,"

wrote M.A. Babizhayev and colleagues.

Babizhayev and colleagues published their study in
American Journal of Therapeutics
(
N-Acetylcarnosine Lubricant Eyedrops
Possess All-In-One Universal Antioxidant Protective Effects
of L-Carnosine in Aqueous and Lipid Membrane Environments,
Aldehyde Scavenging, and Transglycation Activities
Inherent to Cataracts:
A Clinical Study of. American Journal of Therapeutics,
UNKNOWN DATE;16(6):517-533
).
For additional information, contact
M.A. Babizhayev, Innovat Vis Prod Inc.,
Moscow Division, Ivanovskaya 20, Suite 74, Moscow 127434, Russia.
The publisher of the American Journal of Therapeutics
can be contacted at: Lippincott Williams & Wilkins,
530 Walnut St., Philadelphia, PA 19106-3621, USA.

medications that increase blindness risk

6.22:

pills vs eyes 2008:

Open-angle glaucoma
((a bunch of corticosteroids))

Angle-closure glaucoma:

--[ what do these drugs have in common with eph? ]
[any anticholinergic may precipitate narrow-angle glaucoma]
cimetidine     TAGAMET
ephedrine   PRIMATENE, eph
epinephrine     ADRENALINE, PRIMATENE MIST
fluoxetine     PROZAC, SERAFEM
fluvoxamine     LUVOX
ipratropium     ATROVENT
paroxetine     PAXIL, PEXEVA
ranitidine     ZANTAC
sulfamethoxazole (with trimethoprim)     BACTRIM, COTRIM, SEPTRA
sulfisoxazole     GANTRISIN
topiramate     TOPAMAX
venlafaxine     EFFEXOR, EFFEXOR XR

Cataracts

betamethasone     ALPHATREX, DIPROLENE, DIPROSONE
busulfan     BUSULFEX, MYLERAN
chlorpromazine     THORAZINE
desoximetasone     TOPICORT
dexamethasone     DECADRON, HEXADROL, MYMETHASONE
fluocinolone     SYNALAR
fluocinonide     LIDEX-E, LIDEX
hydrocortisone (oral)     CORTEF, HYDROCORTONE
hydrocortisone (topical)     ALA-CORT, HI-COR, HYTONE, NEACLEAR LIQUID OXYGEN SCAR, PENECORT, SYNACORT
methylprednisolone     MEDROL
prednisolone     PRELONE
prednisone     DELTASONE
thioridazine     MELLARIL
triamcinolone (injectable)    
triamcinolone (topical)     ARISTOCORT, KENALOG, TRIACET, TRIDERM

Retinal Abnormalities

acitretin     SORITANE
chloroquine     ARALEN
chlorpromazine     THORAZINE
etretinate     TEGISON
hydroxychloroquine     PLAQUENIL
isotretinoin     ACCUTANE
tamoxifen     NOLVADEX
thioridazine     MELLARIL
tretinoin     RENOVA, RETIN-A
vitamin A (retinol)     AQUASOL A

Optic Nerve Diseases

amiodarone     CORDARONE, PACERONE
ethambutol    
linezolid     ZYVOX
sildenafil     VIAGRA
tadalafil     CIALIS
vardenafil     LEVITRA

sleeping aids

dalmane is a benzodiazepine

dalmane cataracts heavily affect females:
. of the few people developing Cataracts while on Dalmane
most were women, and 21% were
age 20..30 -- very early for cataracts .
[6.29:
. keep in mind that nothing here is proven;
because, it's epidemiology,
not data from randomized studies .
-- this reminds that the pharm'industry
was once notorious for allowing women to be users,
but not including women in their pre-market trials;
dalmane could be one of these?
had they taken women's chemistry into account,
there may have been a different presentation of it ? ]

anti-aggressives

benzodiazepines are related to anti-aggressives:

Epidemiological reviews have suggested
a possible link between cataract occurrence
and other psychotropic medications,
including benzodiazepines .
. long-term use of corticosteroids, phenothiazines,
certain other antipsychotic drugs,
some antineoplastic agents, and amiodarone
may increase cataract incidence.

. in the mid-1960s,
a decade after the marketing of phenothiazines,
drug-related ocular changes were reported in
patients who had been receiving years of
high-dose antipsychotic medication;
chlorpromazine was the primary offender.

Research also associated cataract occurrence with
other phenothiazines;
thioridazine, thiothixene,
trifluoperazine, levomepromazine,
and perphenazine are frequently cited examples.

A 1999 study of cataract occurrence
compared schizophrenic patients (26%)
with the general population (<1%).
. in addition to pharmaceutical exposures
schiz'ics often have additional risk factors:
smoking and poor dietary habits,
along with emotion-based metabolic disorders
(high cortisol, high insulin,
and blood sugar instabilities) .
[6.21:
. some of the new atypicals are clearly
increasing carb' intolerance,
and thus any cataracts blamed on sugar instabilities
must again point the blame at these meds .]

Epidemiological reviews have suggested
a possible link between cataract occurrence
and other psychotropic medications,
including benzodiazepines
and certain antidepressants
of the tricyclic and mao inhibitor classes .

ref# Exposure to phenothiazine drugs and risk of cataract.
Arch Ophthalmol. 1991;109(2):256-260.

Clinical reports have indicated an increased risk of
ocular opacities in users of phenothiazine drugs,
and some recent epidemiologic studies have found
an association between cataract and a
history of tranquilizer use.
To examine the effects of major tranquilizers
(phenothiazines and haloperidol)
on the risk of cataract extraction,
while controlling for suspected risk factors
such as diabetes and steroid use,
a matched cohort study was performed .
The use of either antipsychotic
or other phenothiazine drugs
increased the risk of cataract extraction
by roughly 3.5 times
in those who were both current users
and were exposed some time in the
2 to 5 years prior to their extraction.
Risk was also increased in individuals with
prior use of
antidiabetic agents,
systemic steroids,
and benzodiazepines.

ref# Sunlight and other risk factors for cataracts:
an epidemiologic study.
American Journal of Public Health, Vol. 78, Issue 11 1459-1462

. relation between individual exposure to sunlight
and the risk of cataracts.
Sunlight exposure was very slightly related to
all types of opacities combined.
Although the numbers of cases with
each type of opacity was small,
the risk of cataracts was slightly increased
in medium and high exposure categories
for persons having cortical or
posterior subcapsular opacities only,
but not nuclear sclerotic changes.
Persons with dark brown or hazel eyes
are at increased risk.
An unexpected finding was that
persons who reported using tranquilizers
for six months were at increased risk.

renewed interest in issue with anti-aggressives

. recent questions about quetiapine (seroquel)
as a possible cataract inducer
have increased the current interest in this issue
across the antipsychotic pharmacotherapy spectrum.

. photosensitizing agents
like chlorpromazine and its metabolites
denature proteins,
which become opacified when exposed to sunlight
and are deposited in the lens, cornea, and skin.
Melanin is also considered a probable cause
of lens discoloration
because it traps free radicals produced by
chlorpromazine.
Melanin and chlorpromazine
have a strong bonding affinity.
When chlorpromazine interacts with
ultraviolet-B light,
it produces purple or bluish colored
free-radical metabolites.
This phototoxic reaction creates the
cataract cellular changes.

-- agingeye.net's summary:
Thorazine has been shown to be associated with
pigmented corneal deposits
and anterior capsular cataracts.
Pigmentary retinopathy is usually associated with
a much higher dose (>2400 mg/d).
Pigment deposition on the cornea and lens
appears to be dose related and is usually irreversible.
Chlorpromazine-induced anterior cataracts
do not normally extend to the rest of the lens
even when patients continue taking chlorpromazine.
They usually enjoy good vision for a long period
despite a dense cataract at the pupillary region.
Thioridazine (Mellaril)

has also been reported to induce
lenticular changes unrelated to pigmentary retinopathy.
[Siddall J:
Ocular complications related to phenothiazines.
Dis Nerv Syst 1968; 29:10-13]
However, contrary reports have indicated
no evidence of lens opacity
in patients taking this drug.
[Barnes G, Cameron M:
Skin and eye changes with chlorpromazine therapy.
Med J Aust 1966; 1:478-481]
the risk of cataract occurrence remains unclear.

[6.29:
it's mainly known for retinopathy:
(Thioridazine can remain bound to melanin
in the retinal pigment epithelial cells
for many years with progressive visual loss
despite discontinuation of their use.)]
Ziprasidone (Geodon)

Cataract occurrence was observed as an infrequent finding
during screening for adverse events
before ziprasidone was approved for clinical use.
[Geodon, in Physicians' Desk Reference, 56th ed.
Montvale, NJ, Medical Economics Co, 2002, pp 2688-2692]
However, there is no known causal connection
between this drug and lenticular opacities.

6.22:
Claudio Cepeda`Psychotic symptoms in children and adolescents

. cataracts from chlorpromazine, thioridazine, and perphenazine
seem to be more frequent in young schiz'ic's
with rates in 22 ... 26%;
the young schiz'ics have an 82%
overall ocular pathology rate .
. these numbers seemed consistent with
smoking and diabetic effects
and there are multiple sources of diabetes
in most schiz'ics:
chronic stress, poor sleep, and bad diet .
. thioridazine > 800 mg results in
irreversible retinal pigmentation
which can result in blindness .

Handbook of Psychiatric Drug Therapy
 By Lawrence A. Labbate,

[. among the antipersonell drugs
-- anti-psychotics, anti-aggressives --
all the highly sedating ones
{ thioridazine
, chlorpromazine
, quetiapine
} are suspected of causing cataracts;
is this true also for any of the
moderately sedating: ?
{ fluphenazine
, trifluoperazine
, loxapine
, molindone
} ]

. any anticholinergic may precipitate
narrow-angle glaucoma;
this happens less with the higher-potency 1st gen's,
and by avoiding co.use of antiparkinson drugs,
most of which are anticholinergics
(another class of antiparkinson drugs
is the dopamine releaser, eg: amantadine).
. thioridazine has potent anticholinergic effects .

. the antipsychotics best known for
not causing weight gain (abilify, geodon)
also may cause insomnia that leads to
co.use of benzodiazepines or trazodone;
benzodiazepines are anticholinergic .

[trazodone is weakly anticholinergic
but used cautiously on elders who have
glaucoma, especially angle-closure .]

. non-sedating antipsychotics are also
the most likely among
later generation antipsychotics to cause
akathisia (6.29:
that is the feeling of
getting sick from having to sit still;
but moving around doesn't really help
because the lack of stimulation
has to do with the way certain meds
can affect your neuro-hormones .
people with natural akathisia
are said to have attention deficit disorder,
and the cure is amphetamines;
generally the opposite of anti-dopaminergics)
. akathisia is more likely in
the higher-powered 1st-gen's
(they have less anticholinergic properties);
so they may be co.used with
sedatives:
# beta-adrenergic blockers
(propranolol or nadolol);
# or rarely a benzodiazepine or clonidine .

. quetiapine induces cataracts in animals
so the product label susggests slit-lamp exam's;
ophthalmologic studies find no evidence
supporting regular eye exam's;
however, since schiz'ics have
other risk factors for cataracts,
a referral to an ophthalmologist
for an eye exam
can be part of routine medical care

[6.29:
. but that shouldn't be expected;
not in tightly managed hmo's, right? ]

[. in the section on endocrine side effects
there's no mention of effects on thyroid;
of course,
there's no mention of insulin either,
but there's a whole section reserved for
"(weight gain),
and that's all with a chapter titled:
"(metabolic monitoring for 2nd-gen antipsychotics) !
...
. plus, what do you say about something like dhea,
after your profession has publically said
dhea seems to have no function ? ]

. diabetic ketoacidosis remains a rare possiblity
for all these antipsychotics .

. among the new anti-aggressives,
ziprasidone and aripiprazole cause
the least weight gain,

[ziprasidone is not a sedative;
if you're used to sedatives,
it can cause eno' anxiety to inhibit appetite .]

. all schiz'ics on 2nd-generation antipsychotics
should be monitored at least twice yearly
for glucose abnormalities
and lipid profile .

[is ziprasidone 2nd generation?
it specifically prefaced the call for
diabetes monitoring
with the assertion that ziprasidone
was causing no glucose abnormalities .
6.29:
. yea, but geodon's anx might increase
carb intolerance?
or they could be saying that
one may as well operate as if
geodon is not being used,
because they don't think highly of it
(they mention the profession was finding out
the dose needed to suppress aggression
is considerably higher than documented
and the new dose and rate of attack
could precipitate a cardiac event .]