2014-01-31

acetylcysteine can inhibit anti-cancer p53 protein

30: news.health/acetylcysteine can inhibit anti-cancer p53 protein:
31: summary:
. N-acetylcysteine or NAC is a source of cysteine,
but is too powerful an antioxidant .
. a better source of cysteine is egg yolk:
it too is great at raising glutathione,
a safe antioxidant made by the body .
sciencenews.org:
Tumors in mice with early stages of lung cancer
developed faster when the animals were given
vitamin E and NAC (N-acetyl-cysteine).
. the combo reduced levels of p53,
a protein that suppresses tumor development .
Science Translation Medicine (January 29):
" RNA sequencing revealed that
NAC and vitamin E,
produce highly coordinated changes
in tumor transcriptome profiles,
dominated by reduced expression of
endogenous antioxidant genes.
. NAC and vitamin E increase
tumor cell proliferation by reducing
ROS (reactive oxygen species),
[tumor's] DNA damage, and p53 expression ...
. antioxidants accelerate tumor growth
by disrupting the ROS-p53 axis.
. Pearson & Shaw research warned that
" NAC is such a powerful antioxidant
that it can inhibit ROS signaling
--[ even without combination with vitamin E ].
. and, ROS signaling "is a necessary part of
many normal chemical pathways".

. it's better to get your cysteine
some other way, such as egg yolks .
. cysteine and selenium are the rate-limiting
ingredients of Glutathione production,
the foundation of natural antioxidant protection .