2015-07-28

many safe products now part of #cancer conspiracy

7.25: news.health/cancer/
many safe products now part of cancer conspiracy:
summary:
. many chemicals in our environment
are not classed as carcinogens because
they are not by themselves mutagens;
but many chemicals deemed to be safe
can conspire to contribute to cancer risk.

The Halifax Project
. sponsored by the Canadian nonprofit organization
Getting to Know Cancer.
The organization’s mission is to
advance scientific knowledge about
cancer linked to environmental exposures.
their study is:
Assessing the carcinogenic potential of
low-dose exposures to chemical mixtures
in the environment: the challenge ahead.
Carcinogenesis 2015

summary of kurzweil's summary:
. the fraction of cancers attributable to
toxic environmental exposures is between 7% and 19%.
To explore the hypothesis that low-dose exposures to
mixtures of chemicals in the environment
may be combining to contribute to
environmental carcinogenesis,
The researchers reviewed the actions of these chemicals
against a long list of mechanisms
-- besides mutagenicity --
that are important for cancer development.
For example, EDTA, a metal-ion-binding compound
interferes with the body’s repair of damaged genes.

In their survey, the researchers learned that
50 of the 85 chemicals they looked at,
had been shown to disrupt functioning of cells
in ways that correlated with known
early patterns of cancer,
even at the low, presumably benign levels
at which most people are exposed.

the cancer conspirators:
. the following chemicals don't cause cancer
but they support conditions that benefit cancer,
eg, affecting DNA damage signaling, DNA repair,
epigenetic regulation or mitochondrial function;
targeting estrogen receptor α
or other steroid hormone receptors;
targeting growth factors and their receptors;
etc.
"Our current understanding of the biology of cancer
suggests that the cumulative effects of
(non-carcinogenic) chemicals
acting on different pathways that are relevant to cancer,
and on a variety of cancer-relevant
systems, organs, tissues and cells
could conspire to produce carcinogenic synergies
that will be overlooked using current risk assessment methods."
. in other words, in addition to known carcinogens
look at your use of the following chemicals
before assuming your cancer risk is minimal.
. the titles of the following paragraphs
indicates how the substance helps cancers.

Genetic instability:
(the following items might help cancer
by promoting genetic instability):
lead, nickel, cobalt and mercury
Alloy particles, containing tungsten, nickel and cobalt,
Acrylamide
Bisphenol A (BPA)
fungicide benomyl
Halobenzoquinones
(disinfection by-products in chlorinated water)
Quinones are electrophilic compounds;
nano-sized materials
(used in cosmetics, biomedical, textiles, food, plastics and paints).

Tumor-promoting inflammation:
BPA
polybrominated diphenyl ethers (PBDEs)
vinclozolin exposure in utero

Sustained proliferative signaling:
insecticides and fungicides (cyprodinil, etoxazole,
imazalil, lactofen, maneb, methoxychlor (MXC),
phosalone, prochloraz and pyridaben)
BPA
polyfluorinated octinoid sulfate
and polybrominated diphenylethers (flame retardants)
phthalates (plasticizers)
edible oil adulterants (food processing contaminants)
Catechol estrogens (hydroxyl derivatives of estrogens),
trenbolone acetate (a synthetic anabolic steroid)

Insensitivity to antigrowth signals:
BPA,
pesticides (DDT, folpet and atrazine),

Resistance to cell death(apoptosis):
BPA
Chlorothalonil fungicide
Dibutyl phthalate and diethylhexyl phthalate (DEHP)
Lindane pesticide
MXC DDT replacement
(1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane)

Replicative immortality:
. "chemicals that target specific proteins on the senescence pathways
and may affect the initiation of tumorigenesis
by other compounds allowing senescence bypass":
acetaminophen, cotinine, nitric oxide, Na-selenite, lead.

Angiogenesis(formation of new blood vessels):
diniconazole pesticide,
HPTE (2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane),
methylene bis(thiocyanate),
perfluorooctane sulfonate (PFOS),
Ziram, biphenyl, chlorothalonil,
tributyltin chloride and bisphenol AF.

Tissue invasion and metastasis:
tetrabromobisphenol A and its metabolites,
BPA and tetrabromobisphenol A dimethyl ether,
hexavalent chromium
formaldehyde,
bacteria, e.g. H. pylori,

Tumor microenvironment:
nickel chloride
Prenatal exposure to BPA
Butyltins, and specifically tributyltin,
Methylmercury (MeHg)
paraquat

Avoiding immune destruction:
triclosan and BPA(personal care products)
DEHP (phthalate)