2014-12-28

AIDS from organ transplant antirejection drugs

6.21: web.med/organ transplant/AIDS from antirejection drugs:
summary:
. the first year after transplant with antirejectives
there is increased risk of the same sort of cancers
seen by those with AIDS from HIV infection;
5 years later there is an increased risk of
all the most common cancers .
. if you can get a transplant from a close relative
there is a chance of living without antirejectives .

. antirejectives are immunosuppressive drugs
used for preventing the immune system
from rejecting a transplanted organ .

dermatologists:
. transplant patients tend to
develop their first skin cancer
2 to 4 years after the transplant operation.
a close match can save your health:
. lifetime anti-rejection drugs increase risk of
heart disease, infection, cancer and diabetes.
A Stanford University Medical School team
reports it has successfully performed
kidney transplants that don't require
forever taking anti-rejection drugs .
. the patients in this portion of the study
were perfectly matched with their donors,
as far as immunological markers are concerned.
All 12 of the recipients in this study
received organs from close relatives
who were immunologically matched to them
and achieved success in only 8;
but the weaning process might be improved .
cancers on antirejectives:
. taking anti-rejection drugs is the basis for
higher rate of virus-initiated cancers:
# within the first year after transplant:
lymphoproliferation (Epstein-Barr virus)
skin cancer
Kaposi’s sarcoma(human herpes virus 8)
-- [typical of HIV AIDS]
renal cell carcinoma
cervical cancer (human papillomavirus)
# within 5 years after transplant:
more skin cancer
head and neck cancer (typically viral)
gynecological cancer (viral)
lymphoma,
breast and colon cancer .