2012-02-25

modulation of hormones with food and herbs #cancer #hormonics #BHRT

2.25: web.health/hormonics/anti-cancer
modulation of hormones with food and herbs:
[!] adapted from: 11.9.23:
news.health/hormonics/meridianvalleylab.com

intro:
. this explains how hormones of both men and women
can be affected by dietary changes .
. both men and women are often over-producing their
estrogen, cortisol, insulin,
and are thereby mismanaging their
progesterone, DHEA, and testosterone .
. this advice is mainly a paraphrasing of the
naturopathic doctor, Dr. Barry Wheeler,
who uses bio-identical hormone replacement therapy
while testing for current hormone levels
(see resources at bottom).

cancer prevention: estrogen quotient(EQ)

 EQ(should be > 1 ) =
            E3[estriol]
-----------------------------------------
(E1[estrone] + E2[estradiol])

. an iodine + iodide mix can induce a healthy EQ
by converting E1 to E3,
(16-alpha-hydroxy-estrone is a middle step)
. use 3...4 doses of {Iodoral, i-Throid}
or 6...8 drops of Lugol’s iodine (Rx).
[. an iodine-rich diet is yet another reason why
the Japanese are protected from breast cancer .]

DHEA is anti-cancer but beware oral use:
. low DHEA can increase the risk of cancer;
but oral DHEA is a common cause of high estrone (E1);
use it only transdermally [cream, inhaled] .

methyl-donors are anti-cancer agents:
. E1 and and esp'ly 4-hydroxy-E1
increase cancer risk.
. a diet that raises 2-methoxy-E2
can usually lower 4-hydroxy-E1 levels .
. this is done with methyl-donors:
# the methylcobalamin form of vitamin B12,
# the methylfolate form of folate/folic acid,
# S-adenosylmethionine (SAMe),
# betaine, and glutathione.

The 2/16 ratio:

. conversion of E1 to the good E3
is done by first producing the pro-cancer
16-alpha-hydroxy-estrone;
and then converting that to anti-cancer E3 .
. things that reduce 16-alpha-hydroxy-estrone
will tend to raise 2-hydroxy-estrone .

. the Brassica family can shift 2/16 ratio:
(Broccoli, cauliflower, cabbage, Brussels sprouts,
bok choy, mustard greens, and kale)
. the active ingredient is indole-3-carbinol (I3C)
and di-indolylmethane (DIM);
but, if using a veg'concentrate, beware overdose:
they can stop E1 from being converted to the E3
that is needed to maintain a healthy EQ
and avoid osteoporosis .
. men who eat Brassica vegetables four times a week
have 40 % less risk of prostate cancer .

Other supplements for 2/16 ratio:
magnesium (300 milligrams daily),
vitamin B6 (50 milligrams a day)[beware nerve damage]
vitamin E (600 IU at bedtime)[beware flu eroding heart]

paths for making testosterone:

. not only is testosterone decreasing in elder men,
but estrogens may increase by up to 40% .
. aromatase converts T to estradiol,
while 5AR (5-alpha-reductase) converts T to
DHT (5α-dihydro-testosterone).

. the 5AR is also doing other conversions as well:
# Androstenedione -> andosterone
# Cortisol -> allo-tetrahydro-cortisol .
. DHEA up-regulates 5AR activity
[ ... perhaps this how it balances cortisol,
by reducing it to allo-tetrahydro-cortisol ?]

Progesterone inhibits 5AR .
[. often thought of as a woman's hormone,
progesterone is the man's primary device for
preserving testosterone! ]

convert DHT to anti-cancer hormones:

. it's a myth that DHT needs to be suppressed;
while an over-abundance of DHT can be a sign of
estrogen's dominance over progesterone,
the other key to avoiding prostate cancer may be found in
converting any DHT to the anti-cancer androgens:

# androstanediol, [(5α-androstane-3α,17β-diol)
-- also known as 3α-diol (3α-Androstanediol)  --
is catalyzed by the enzyme 3-α-HSD .]
[. 3α-diol can be potent:
it can provide a key signal for progression of
androgen-independent prostate cancer .

# 3β-Adiol  (5-alpha-androstane-3-beta-17-beta-diol).
[3β-Androstanediol catalyzed by the enzyme 3-β-HSD .]
. 3β-adiol is inhibited by some Heavy metals,
such as cadmium and arsenic (prostate cancer risks).
. 3β-Adiol stimulates only estrogen receptor beta,
and has anti-proliferative and re-differentiation activities;
it also modulates the brain's stress response .

 . beware powerful anti-DHT prescriptions
-- the 5-alpha reductase inhibitors --
because they are also lowering androsterone[s] .
. Saw palmetto can lower 3β-Adiol too much .

. the best way to control DHT production
is by maintaining progesterone function
(don't have too much estrogen).
. some food ingredients are 5-alpha reductase inhibitors:
    GLA (grass fed animals)
    EPA fish oils,
    Vitamin D3
    Zinc -- B6 can potentiate this .

testosterone's aromatization to estrogen:

. ways men make estrogen:
# androstenedione -> testosterone -> estradiol
# androstenedione -> estrone .
. chronic high insulin is the main cause of
men's testosterone being aromatized into estrogens;
however, a low-insulin diet is not a quick fix:
it could take 2 years to normalize aromatization .

. herbal ways to reduce aromatization include
Myomin (a combination of Chinese botanicals)
and chrysin liposomal spray ).
[. I could not find any liposomal versions of chrysin ...]

[Dr Chi's Myomin:
Myomin contains Aralia, and Cyperus rotundus;
both reduce estradiol [volume and function]:
by inhibiting the aromatase enzyme,
and preventing estradiol from binding to receptors.
. Myomin also contains Smilax glabra, [anti-diabetic]
and Curcurma zedoria .
. Myomin may raise levels of interferon (IFN)
to stimulate natural killer cells,
and raise interleukin-2 (IL-2)
to induce the proliferation of immune cells .]
[ Curcurma zedoria(White Turmeric):
Chang Minyi` AntiCancer Medical Herbs
(Hunan Science and Technology Publishing House, 1992):
Curcuma zedoaria ... breaks ribosoma formation in cancer cells, ... .
.... possibly related to
RIP (Ribosome inactivating protein) function .]

resources:

# Dr. Barry Wheeler's hormone balancing articles .
# Bio-Identical Hormone Replacement (BRHT):
risks you should know and how to reduce them
# BHRT is not easy after HRT proven wrong
# other Nutrition & Healing articles
# Bioidentical hormone Physician referrals:
American College for the Advancement in Medicine
or the American Academy of Environmental Medicine .
# Wright`Taking The Fear Out of
Bio-Identical Hormone Replacement Therapy
- One Urine Test at a Time
# more about chinese herbs .