2023.3.2: web.health/diet/aspirin/blindness/
low-dose aspirin seems good for eyes except with vitamins:
summary:
. there are some studies that seemed to show
that aspirin increased your risk of blindness;
but the best type of study (randomized trials)
showed they actually reduced the risk of blindness
unless you happen to be the user of multivitamins.
. one study showed that only people with good genes
may benefit from a good diet;
but you should be safe from AMD blindness if you
limit both omega-6 vegetable oils and your glycemic load.
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C3&q=omega-6+%2C+amd+blindness
Ophthalmology. 2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875604/
The association of aspirin use with
age-related macular degeneration progression
in the Age-Related Eye Disease Studies: AREDS2 Report No. 20.
. there are 2 randomized clinical trials:
Arch Ophthalmol. 2001:
Age-related maculopathy in a randomized trial of low-dose aspirin among US physicians.
Ophthalmology. 2009:
Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women.
. using 100mg aspirin every other day
slightly reduced your risk of AMD
yet increased your risk if you used certain multivitamin supplements.
"Among current nonusers of multivitamins,
those in the aspirin group had a statistically-significant
32% reduced risk of AMD (HR, 0.68; 95% CI, 0.49−0.95)
whereas among current users of multivitamins,
there was a nonsignificant 14% increased risk of AMD
in the aspirin group (HR, 1.14; 95% CI, 0.76−1.70)"
[ Ophthalmology. 2009
https://pubmed.ncbi.nlm.nih.gov/19815293/
Low-Dose Aspirin and Medical Record Confirmed
Age-related Macular Degeneration in a Randomized Trial of Women;
William G. Christen, Sc.D, et al.]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787838/
"men assigned to alternate-day low-dose aspirin (325 mg)
had a statistically non-significant
22% reduced risk of visually-significant AMD
during a five year treatment period."
. placebo terminated early due to aspirin causing
a 44% reduced risk of first myocardial infarction.
[ Arch Ophthalmol. 2001
https://pubmed.ncbi.nlm.nih.gov/11483080/
Age-related maculopathy in a randomized trial of
low-dose aspirin among US physicians;
W G Christen et al.]
"In AREDS, both aMedi[Mediterranean-type diet] and its fish component
interacted with CFH rs10922109 for late AMD
(P = 0.01 and P = 0.0005, respectively);
higher aMedi and fish intake were each associated with
decreased risk of AMD only in participants with protective alleles.
Closer adherence to a Mediterranean-type diet
was associated with lower risk of progression to late AMD and to large drusen.
The signal was greater for GA than neovascular AMD.
Fish intake contributed to this protective association.
CFH genotype strongly influenced these relationships.
Hazard ratios (HRs) for progression in aMedi tertile 3 versus 1
were 0.78 (95% confidence interval [CI], 0.71-0.85, P < 0.0001)
for late AMD, 0.71 (0.63-0.80, P < 0.0001) for GA,
and 0.84 (0.75-0.95, P = 0.005) for neovascular AMD.
For fish consumption, HRs for late AMD in quartile 4 versus 1 were
0.69 (0.58-0.82, P < 0.0001; AREDS) and
0.92 (0.78-1.07, P = 0.28; AREDS2).
. the HR for progression to large drusen in aMedi tertile 3 versus 1 was
0.79 (0.68-0.93, P = 0.004)."
[ Ophthalmology. 2020
https://pubmed.ncbi.nlm.nih.gov/32348832/
Adherence to the Mediterranean Diet and Progression to
Late Age-Related Macular Degeneration
in the Age-Related Eye Disease Studies 1 and 2;
Tiarnán D Keenan, et al;
Age-Related Eye Disease Studies (AREDS) 1 and 2 Research Groups.]
Dr. Barry Sears 2002`The Omega Rx Zone:[ad]
The Miracle of the New High-Dose Fish Oil
The Mediterranean Zone: [ad]
Unleash the Power of the World's Healthiest Diet for Superior Weight Loss, Health, and Longevity Hardcover – 2014 by Dr. Barry Sears (Author)
