2014-05-02

PalmitOleic healthier than usual monounsaturate

4.30: news.cook/POA (PalmitOleic acid) Omega-7 mono'oil:
. good fat just got even better!

Dr. Whitcomb:
. POA (PalmitOleic acid) is called an Omega-7
because it has a double bond after 7 carbon atoms;
it's a monounsaturate like olive oil(omega-9).
. it's found in macadamia nuts and palm nuts;
but in these natural sources it's mixed with
a bit of inflammatory palmitic saturated fat,
which counters some POA's beneficial effects .
.
. POA is a lipokine:
it's a fat that acts like a hormone.
it stimulates the production of insulin cells,
increases the glucose uptake of muscle cells
and (in rats) elevates cholecystokinin, 
one of the appetite-suppressing hormones.
.
. POA reduces inflammation in animal models;
that may be related to the SCD1 enzyme
(stearoyl-CoA desaturase 1),
that is a natural source of inflammation in fat tissue;
animals that are missing SCD1 have no inflammation .
.
. by promoting glucose utilization,
POA reduces blood glucose levels
which reduces AGE (advanced glycation end-products)
insulin usage, and CRP (C-reactive protein).
. in an unpublished study, humans with high levels of CRP
nearly halved their levels with Palmitoleic acid .
Provinal Purified Omega-7:
Provinal contains purified palmitoleic acid,
an omega-7 monounsaturated fatty acid (MUFA).
Palmitoleic acid is formed in the body
from the conversion of glucose to fatty acids,
or can be obtained from diet.
. POA has been shown to support healthy cholesterol
and C-reactive protein levels
for those already within a normal range,
and has a beneficial effect on other metabolic parameters.
Palmitoleic acid acts as a direct regulator of metabolism,
with actions including:
Suppression of adipocyte cytokine expression
Promotion of pancreatic B cell proliferation and secretory function to support insulin production and glucose management
Enhancement of skeletal muscle glucose uptake
Stimulation of adipocyte peroxisome proliferator–activated receptor (PPAR)-gamma transcriptional activity,
a nuclear receptor involved in fatty acid metabolism
as well as modulation of cell proliferation and differentiation.
Each softgel contains less than 1% palmitic acid,
which is less than the amount of palmitic acid
contained in half a macadamia nut.
InnovixLabs:
. InnovixLabs uses Provinal brand Purified Omega-7:
the only patented and clinically proven
Omega-7 from fish.
. according to Dr. Mike Roizen, Cleveland Clinic,
As seen on NBC Today show and Dr. Oz's TV Show:
"You only want Purified Omega-7 from fish, not the one from Sea Buckthorn. Sea Buckthorn contains higher levels of Palmitic Acidand it INCREASES inflammation." 
Provinal's details @ drvita.com:
. Concentrated Palmitoleic Acid in Ethyl Ester Form
minimum 50.0% Palmitoleic Acid (C16:1n7)
maximum 1.0% Palmitic Acid
Available in 190 kg and 24 kg Drums
State of the Art GMP Facility (KFDA Approved)
Only Source of Purified Palmitoleic Acid on the Market
From Sustainable Peruvian Anchovy [ or menhaden fish ].
Palmitoleic Acid Shown to Outperform EPA
in Reducing TG [Triglycerides] in Apo-E Mouse Model
Reductions were Larger In Half the Administration Time
At one fifth of the dosage
Unlike Omega 3, Initial Studies Show Reductions in Both
TG and LDL [sugar- and grain- related cholesterol].
. the usual dose of 420 mg Provinal fish oil
contains 210mg of POA .

Sea-licious is Provinol and fish oil:
60 / $22 -- take 2 for the usual POA dose
and for the extra $6 this brand costs you,
2 gives you 2*330 mg sardine/anchovy oil
-- that has 2* ( 53mg EPA, 33mg DHA ).
. it includes natural oil preservatives:
Rosemary, mixed tocopherol, natural lemonade flavor,
sunflower lecithin, ascorbyl palmitate, astaxanthin.
. it is 5-star rated by IFOS testing .
(that limits dioxins, PCB's, mercury and peroxides).
iherb's pure provinol:
30/$15.95 -- buying 12 at iherb

Provinal at amazon:
90/ $44 --- $14.62 per 30 Source-Naturals
30 /$15 InnovixLabs
30 * 500mg Provinol/ $17 drvita.com
30/ $20 lef.org

. last-resort source: bulk mac.oil
-- macadamia with a minimum of 15% POA
comes with a max of 10% palmitic;
keep in mind it's hard to verify oil authenticity;
better to buy the unprocessed nut .

fatty acid composition of macadamia oil:

15% of mac lipids are sat'fat:
C16:0 Palmitic Acid [inflammatory]:
{ 7.0 – 9.5 % 
, 7.4 - 9.1 -- integrifolia
, 8.0 - 10.0 -- tetraphylla }
C12:0 Lauric Acid < 0.5
C14:0 Myristic Acid 0.5 – 1.6
C18:0 Stearic Acid 2.0 – 5.5
C20:0 Arachidoic Acid 1.5 – 3.5
C22:0 Behenic Acid 0.1 – 1.5
82% mono'oil:
C16:1 POA [anti-inflammatory]:
{ 15.0 – 22.0 %
, 18.5 - 21.9 -- integrifolia
, 16.0 - 23.6 -- tetraphylla }
C18:1 Oleic Acid 55.0 – 67.0
C20:1 Eicosenoic Acid 1.5 – 3.8
2.13% poly'oil:
C18:2 Linoleic Acid 1.0 – 5.5 [Omega 6]
C18:3 Linolenic Acid 0.1 – 3.0 [Omega 3]
20:4 Arachidonic acid [inflammatory if omega-6/3 high]:
{ 1.8 - 2.2 -- integrifolia
,  2.7         -- tetraphylla }
--. species data (integrifolia vs tetraphylla) 
same says lipid ratios are (0.14 poly 5.43 mono 1 sat)
thus percentages are: (2.13%, 82%, 15%).

. hazel's have little POA but otherwise they are best at
minimizing sat'fat (especially palmitic acid),
minimizing poly'oils (especially omega-6)
while maximizing any mono'oils .
palmitic, omega-6, mono'oil (g/100g) :
      hazel: 3.1,  8,  45 .
 almonds: 3.2, 12, 32 .
butternut: 0.9, 34, 10 .
-- forget about getting omega-3 from nuts;
you need greens or distilled fish oil .

compared to olive oil:
55 - 83% Oleic Acid (C18:1), omega-9
7.5 - 20% Palmitic Acid (C16:0),

"Identification of a Lipokine, a Lipid Hormone
Linking Adipose Tissue to Systemic Metabolism"
Cell 134, no. 6 (2008): 933–944.
Cleveland Clinic Heart and Vascular Institute,
"Effects of Palmitoleic Acid on HDL Levels
and Cholesterol Deposition in Apo-E Mice"
Tersus Pharmaceuticals, 2009, 
"Chronic Administration of Palmitoleic Acid
Reduces Insulin Resistance and Hepatic Lipid Accumulation
in KK-Ay Mice with Genetic Type 2 Diabetes"
Lipids in Health and Disease 10 (2011): 120.
"Serum Lipid Effects of a High-Monounsaturated Fat Diet on Macadamia Nuts"
Archives of Internal Medicine 160, no. 8 (2000): 1154–1158.