@MonsantoCo #roundup chronic low doses caused #kidney damage in rats

4.19: news.pol/healthcare/roundup/
chronic low doses might cause kidney damage:
. low-dose Roundup might cause kidney damage?
this had caught my eye because recently
I had blamed the increasing kidney damage on
dramatically increasing use of fructose;
but also there has been increasing use of Roundup
(it contaminates much of the water supply now;
it might even be your rain).
and this study says low-dose Roundup in rats
was associated with slow kidney damage
(occurring over years not months).
. tests for gmo's and their associated pesticides
are usually short term (eg, 90-day) studies,
whereas any damage may take several years.

Brian Bienkowski 2015:
Long-term exposure to tiny amounts of Roundup
—thousands of times lower than
what is permitted in U.S. drinking water—
may lead to serious problems in the liver and kidneys,
according to a new study that looked at
the function of genes in these organs.
. the findings bolster a controversial 2012 study
that found rats exposed to small amounts of the herbicide Roundup
had liver and kidney damage.
It is the first to examine the impacts of
chronic, low exposure of Roundup
on genes in livers and kidneys
and suggests another potential health impact for people and animals
from the widely used weed killer.

Environmental Sciences Europe 2014:
Republished study: long-term toxicity of a Roundup herbicide
and a Roundup-tolerant genetically modified maize
Gilles-Eric Séralini, Emilie Clair, Robin Mesnage, Steeve Gress,
Nicolas Defarge, Manuela Malatesta, Didier Hennequin
and Joël Spiroux de Vendômois
Monsanto did 90-day studies to prove
GM food and pesticide safety;
Our findings imply that long-term (2 year) feeding trials
need to be conducted to thoroughly evaluate
the safety of GM foods and pesticides
in their full commercial formulations.
The health effects of a Roundup-tolerant
NK603 genetically modified (GM) maize
(from 11% in the diet),
cultivated with or without Roundup application
and Roundup alone (from 0.1 ppb of the
full pesticide containing glyphosate and adjuvants)
in drinking water,
were evaluated for 2 years in rats.
This study constitutes a follow-up investigation
of a 90-day feeding study conducted by Monsanto
in order to obtain commercial release of this GMO,
employing the same rat strain and analyzing biochemical parameters
on the same number of animals per group as our investigation.
Our research represents the first chronic study
on these substances, in which all observations
including tumors are reported chronologically.
Thus, it was not designed as a carcinogenicity study.
We report the major findings with 34 organs observed
and 56 parameters analyzed at 11 time points for most organs.
Biochemical analyses confirmed very significant
chronic kidney deficiencies,
for all treatments and both sexes;
76% of the altered parameters were kidney-related.
In treated males, liver congestions and necrosis
were 2.5 to 5.5 times higher.
Marked and severe nephropathies [kidney diseases]
were also generally 1.3 to 2.3 times greater.
In females, all treatment groups showed a
two- to three-fold increase in mortality,
and deaths were earlier.
This difference was also evident in
three male groups fed with GM maize.
All results were hormone- and sex-dependent,
and the pathological profiles were comparable.
Females developed large mammary tumors
more frequently and before controls;
the pituitary was the second most disabled organ;
the sex hormonal balance was modified by
consumption of GM maize and Roundup treatments.
Males presented up to four times more
large palpable tumors starting 600 days earlier
than in the control group,
in which only one tumor was noted.
These results may be explained by
not only the non-linear endocrine-disrupting effects of Roundup
but also by the overexpression of the EPSPS transgene
or other mutational effects in the GM maize
and their metabolic consequences.