2014-06-18

curcumin absorption with piperine or Phytosome

1.21: web.cook/curcumin absorption with piperine or Phytosome:
. some believe black pepper is needed
in order to absorb turmeric's curcumin?
. I once said I was leary of black pepper,
but I researched it again,
and found that pepper's piperine extract
is healthier than whole black pepper .
. another way of absorbing curcumin
is by binding it with phosphatidylcholine .
[6.18: curcumin and MAO-B inhibition:
curcumin may inhibit MAO-B .
"Curcumin (10-80 mg/kg, i.p. in mice) dose dependently
increased serotonin (5-hydroxytryptamine, 5-HT)
as well as dopamine levels (at higher doses),
and inhibited MAO-A (and in higher doses, MAO-B)"
[ Psychopharmacology (Berl) 2008 ].

NOW Bio-Curcumin Phytosome 
"is Curcumin with phosphatidylcholine
that clinically demonstrates
increased absorption and bioavailability,
as compared to standard Curcumin extracts.
[just like black pepper's piperine?]
Clinical studies also show that
Bio-Curcumin Phytosome provides
potent antioxidant activity, and
can support a balanced inflammatory response" .
the helpful pepper extract is piperine:
Bioperine, a standardized piperine composition
derived from black pepper extract.
Made by Sabinsa, it is a standardized extract
from the fruit of Piper nigrum (black pepper)
or Piper longum (long pepper).
It contains 95 percent piperine . Sabinsa claims
that Bioperine has been shown in clinical research
to increase the absorption of nutrients
in nutritional supplement formulations.
black pepper has more than piperine:
whole black pepper may be carcinogenic
via some procarcingenic constituents such as
safrole and tannins, and some terpene compounds.
These procarcinogenic effects were noted with
topical application.
Nutrition and Cancer Volume 1, Issue 3, 1979
Black pepper [piper nigrum]: Evidence of carcinogenicity
so the the piperine in pepper
is not among the possible carcinogens;
are phospholipids are better than piperine?

piperine works like this:
. curcumin cannot be utilized due to
its rapid metabolism in the liver and intestinal wall.
. piperine is a known inhibitor of
hepatic and intestinal glucuronidation
wiki:
. substances resulting from glucuronidation
are typically much more water-soluble .
. in summary,
piperine works by keeping the curcumin less water-soluble;
similarly, phospholipids may work by
making the curcumin more fat-soluble,
which might have the same effect as less water-soluble ?