2022.3.9: health/diet/omega-6/
chronic illness increased after oils of soy, grain, and seeds added to diet:
Dr. Chris Knobbe warns us that we are wrong about
omega-6 oil being healthy at higher doses.
AncestryFoundation 2021
https://www.youtube.com/watch?v=sKR1ZdHXXzo
Omega-6 Apocalypse 2 (AHS21)
Catherine Shanahan M.D. 2018: [ad]
http://www.amazon.com/dp/B01G1J7WEU/ref=nosim?tag=americiu-20
Deep Nutrition: Why Your Genes Need Traditional Food.
22.1.2: 2.8: news.health/diet/omega-3/heart
/fish oil reduces risk except for angina patients:
Mayo Clin Proc. 2021 Feb
https://pubmed.ncbi.nlm.nih.gov/32951855/
Effect of Omega-3 Dosage on Cardiovascular Outcomes:
An Updated Meta-Analysis and Meta-Regression of Interventional Trials.
Aldo A Bernasconi, et al.
commentary:
www.sciencedaily.com/releases/2020/09/200917084102.htm
"People should consider the benefits of omega-3 supplements,
at doses of 1000 to 2000 mg per day
-- far higher than what is typical,
even among people who regularly eat fish."
21.7.12: web.health/diet/
Cares Act 2020 required removing guaifenesin from asthma meds:
. why was primatene recalled?
a competitor claimed that the Cares Act 2020
required removing guaifenesin;
possibly due to it being known that
guaifenesin may cause birth defects.
but that was known at least as far back as 2003.
[ Am Fam Physician. 2003:
https://pubmed.ncbi.nlm.nih.gov/12825840/
Over-the-counter medications in pregnancy
Ronald A Black, D Ashley Hill.
https://www.aafp.org/afp/2003/0615/p2517.html
]
2021.8.9: 9.4: health/diet/heart/Berberine/
prevents heart failure through endothelial and calcium function:
GreenMedInfo Research Group July 30th 2021
https://www.greenmedinfo.com/blog/seven-herbs-and-supplements-heart-failure
. something extracted from berberine
is blocking calcium influx, thereby reducing
the risk of heart failure.
Acta Pharmacol Sin. 2010
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002834/
Min-you Qi, Yu Feng, De-zai Dai, Na Li, Yu-si Cheng, Yin Dai.
CPU86017, a berberine derivative, attenuates cardiac failure
through normalizing calcium leakage
and downregulated phospholamban
and exerting antioxidant activity.
Front Physiol. 2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546405/
Miyesaier Abudureyimu, Wenjun Yu, et al.
Berberine Promotes Cardiac Function by
Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure.
. enhancing endothelial function helps heart:
Cardiovasc Drug Rev. 2001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999047/
C W Lau, X Q Yao, Z Y Chen, W H Ko, Y Huang.
Cardiovascular actions of berberine.
. "Endothelial dysfunction is an important early event in the
pathogenesis of atherosclerosis.
The mechanisms underlying endothelial injury are numerous
and linked to metabolic alteration.
In obesity and insulin resistance,
the increased secretion of proinflammatory cytokines
and decreased secretion of adiponectine,
the increased circulating levels of free fatty acids,
and hyperglycaemia may alter gene expression and cell signalling in the vascular endothelium,
contributing to changes in the release of endothelium derived factors.
Dysfunctional endothelium is characterized by activation of NADPH oxidase,
uncoupling of endothelial nitric oxide synthase (eNOS),
increased expression of endothelin-1,
an imbalance between the production of vasodilators and vasoconstrictor mediators,
and induction of adhesion molecules
[31].
The altered endothelial homeostasis, in turn,
contributes to plaque initiation and progression.
It is associated with most cardiovascular disease, such as
hypertension, coronary artery disease, chronic heart failure,
peripheral artery disease, diabetes and chronic renal failure
[32].
Endothelial cells exposed to hypercholesterolemia show a
reduced capacity to release endothelium-derived relaxing factors,
because of LDLc promotion of endothelial eNOS downregulation
[33].
Lowering cholesterol levels appears to improve endothelial function
[34].
In diabetes and insulin resistance, other mechanisms may trigger endothelial dysfunction.
Insulin signalling is altered in these two conditions,
and affects the pathway leading to phosphorylation and activation of eNOS,
which is also, in this case, dramatically downregulated
[35].
eNOS represents a major weapon of endothelial cells to fight vascular disease.
It generates nitric oxide (NO), whose role is to dilate blood vessels
and maintain vascular homeostasis by stimulating cGMP
[36].
Several studies have suggested a central role of endothelial AMPK
in maintaining physiological functions, such as
mediation of eNOS activation in response to shear stress
[37],
modulation of endothelial cell energy supply
[38],
protection from apoptosis
[39]
and regulation of inflammation, angiogenesis, and maintenance of perfusion
[40,41].
Impairment of endothelium dependent relaxation (EDR)
represents reduced eNOS derived NO bioavailability,
and is the first step in endothelial injury.
It is present also in the absence of vessel damage.
In 2000, Ko et al[42], by in vitro investigation,
demonstrated that BBR has not only vasorelaxant
but also antiproliferative effects.
According to their results, BBR could act both on the endothelium
and on the underlying vascular smooth muscle cells to induce relaxation
(Figure (Figure1).1).
NO, is likely involved in the EDR.
More recently, this mechanism has been clarified in endothelial cells isolated from rat.
It was confirmed that the vasodilatant effect of BBR
was mediated by eNOS leading to NO production
through activation of the AMPK cascade.
Moreover, BBR counteracts several adverse effects of hyperglycemia on the endothelium,
including the inhibition of high glucose-induced reactive species
intracellular accumulation and cellular apoptosis and inflammation,
which characterize vascular injury
[31,43].
Another recognized effect of BBR is the significant decrease in
the number of adherent monocytes on endothelial cells,
which is a key event in the early stages of atherosclerosis.
Furthermore, BBR suppresses the activation of the
nuclear factor-κB (NF-κB),
the expression of adhesion molecules (VCAM-1 and ICAM-1)
induced by hyperglycemia
and the high glucose-induced elevation of several pro-inflammatory cytokines and chemokines,
including tumor necrosis factor-α, IL1-β, IL8 and MCP1,
which are other targets of NF-κB
involved in the development of atherosclerotic plaques
[43]"
fig 1:
. Berberine enhances endothelial function 3 ways:
it affects AMPK (Adenosine mono-phosphate kinase)
that affects eNOS (Endothelial nitric oxide synthase);
it lowers LDL-cholesterol and triglycerides;
and, it improves insulin sensitivity.
enzymedica Berberine 60 /$20.62
https://www.lifeextension.com/vitamins-supplements/item53349/berberine
Enteric-coated to prevent self-aggregation and formation of berberine crystals that reduce absorption.
Enzymedica's Berberine is provided in a
targeted delivery capsule
to prevent release of berberine in the stomach.
since in an acidic environment, berberine will bind with other berberine molecules
to form insoluble complexes that do not get absorbed.
Prevention of the formation of these complexes
may improve the absorption of berberine.
Amount Per Serving
Berberine HCI (97%) (from berberis vulgaris extract) (seed) 500 mg
Leucine 50 mg
Other Ingredients: 100% vegetarian capsule (cellulose, gellan gum, water),
rice concentrate, calcium laurate
[Calcium laurate helps powders flow into capsules
and holds those powders together.]
Dr. Michael Murray:
https://www.iherb.com/pr/enzymedica-berberine-60-capsules/81507
"Berberine is commonly harvested from the flesh, roots or bark of plants
like barberry, goldenseal and Oregon grape.
Unlike many other formulas, this product is sustainably sourced from
barberry seeds and does not require the plant to be sacrificed in its production.
Nutricology, Berberine 500, 90
https://www.iherb.com/pr/nutricology-berberine-500-90-vegetarian-capsules/82073
Hydroxypropyl methylcellulose,
Nu-MAG® (rice extract, rice hulls, gum arabic, sunflower oil),
silicon dioxide, microcrystalline cellulose.
https://ribus.com/nu-mag/
Nu-MAG offers formulators a Certified Organic alternative to Magnesium Stearate,
so organic tablets requiring a lubricant can now be produced.
Thorne Research, Berbercap, 60
https://www.iherb.com/pr/thorne-research-berbercap-60-capsules/18577
Microcrystalline cellulose, leucine, silicon dioxide.
Berberis concentrate berberine HCl 85%.
Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata) 200 mg
Whitaker Nutrition, Clinical Grade, Berberine, 90 Capsule
https://www.iherb.com/pr/whitaker-nutrition-clinical-grade-berberine-1-500-mg-90-capsules/101131
Berberine Hydrochloride (BerberPure™) 500 mg (take 3)
Microcrystalline cellulose, gelatin, magnesium stearate, gum acacia, silica.
2021.8.4, 9.15: health/immunity/covid-19/
T cells can reveal a covid infection even if antibodies waned
9.15: summary:
. if you had a mild case of covid,
or it has been a while since you've been infected,
your antibody levels may be too low to measure,
but your T cells can still be measured
to determine if you've been exposed to covid virus.
. the CDC says you should get the vaccine
even if you have been infected,
so what's the use in knowing your status?
. you may be less likely to get sick again
if the vaccine doesn't cover some variants,
but the infection does cover the variants.
. you may want reassurance after vaccination
that even if the vaccine doesn't work on your variant,
you might still be protected by your infection.
. if you believe that, the CDC reminds you,
there are significant risks to getting infected;
not just death but also strange chronic illness;
so it's safer to get vaccinated than infected.
. even for children who are prone to having
bad reactions to the vaccine,
there are even more reactions to the virus.
. without any early treatment options available
(whether by politics or science)
there will be many more deaths from virus
than there will be deaths from vaccine.
2021.9.15: health/immunity/covid-19/diet/
slow-carb fish eaters less prone to severe covid:
Jordi Merino, PhD:
https://www.sciencedaily.com/releases/2021/09/210908180530.htm
"Our models estimate that nearly a
third of COVID-19 cases would have
been prevented if one of two exposures
-- [uhealthy] diet or deprivation --
were not present."
2021.7.26, 8.31: news.health/immunity/covid-19/
natural immunity after infection persists even with low antibodies:
summary:
. it is shown that after a covid-19 infection
there is long-lasting immunity
even when the antibody count is low
because covid-19 is slowly developing
thereby giving the memory cells time to react
by growing more antibodies when needed.
. the CDC recommends even those who have been infected
should get the vaccine; apparently because,
the recently vaccinated with their higher antibodies,
will be quicker at stopping the spread of the virus
than people who have survived an infection and then
slowly make more antibodies when reinfected.
. the politics of this question are based on
a dispute over the likelihood of vaccine injury.
21.2.19: co.reddit/news.health/diet/omega-3/
high fat vs high carb diet improves omega-3 vs 6 ratio?:
. even when the diet's omega-6/omega-3 ratios are nearly the same,
the High fat diet group had a lower omega-6/omega-3 ratio
than the High carb diet group.
21.1.28: web.cook/krill/brands with 3rd party testing:
[5.12: summary:
. some say the best thing about krill oil
is that it provides phospholipids,
but you could get that from lecithin;
what is great about krill oil,
is having a phospholipid combined with fish oil,
instead of some lesser-needed oil.
. when buying oils from seafood,
quality may benefit from 3rd party testing.
I tried chewing the IKOS-tested Sports Research
and was amazed at how fishy and weird it tastes;
meanwhile, MegaRed has no 3rd-party testing
but it has a pleasant taste; nevertheless,
I would still prefer IKOS-tested products.]
IKOS® Sports Research, 400mg phospholipids* 60/subscribe $25.46
https://smile.amazon.com/Antarctic-Strength-Omega-3s-Astaxanthin-Softgels/dp/B00IP1E3O0
--warned about deliveries keep happening after unsubscribe.
same from iherb/$31.15
IKOS® vivanaturals Antarctic Krill Oil 575mg phospholipids * 30/$25.15
https://smile.amazon.com/Viva-Naturals-Premium-Antarctic-Krill/dp/B004TBCT4G/
21.1.25: web.cook/ph/
find new supplier of progesterone with minimal additives:
summary:
. progesterone is both a male and female hormone,
but many versions of it are targeted at women,
and may contain estrogenic herbs that men don't want.
. my preferred retailers are amazon and iherb;
I chose Emerita Pro-Gest from iherb.
item I used got discontinued:
Bonvida 1g Progesterone in 60g Cream
https://smile.amazon.com/gp/product/B00XBBASS4/ref=ox_sc_saved_title_4?smid=AARS6R64IWAEZ&psc=1
purchased 2020.9.11 -- was using about 8mg per day.
other prostate health offerings:
https://www.nowfoods.com/supplements/prostate-health-clinical-strength-softgels
https://www.nowfoods.com/supplements/prostate-support-softgels
fake news about progesterone:
woman claims Dr.Lee said you can't overdose on cream:
https://www.bmj.com/rapid-response/2011/10/30/warning-about-natural-progesterone
[5.12:. in at least one book by Dr.Lee, he warned about
how easy it was to over-dose on progesterone cream;
and that you had to consider that too much
could have the opposite effect.
Dr. Mercola has commented on Dr.Lee,
warning us that applying this to skin is not the best;
you should be applying it to a mucous membrane
(I've been using it nasally with good results).]
. the following list is sorted with
the first being the most preferred for men.
health/immunity/covid-19/
is the risk from having African ancestry or being carb-intolerant?:
2021.2.4:
. africs (those with some African ancestry)
are said to be more prone to severe covid-19:
is it happening even to africs on a slow carb diet?
(a diet low in sugars and baked goods).
. we know that obese euros (whites)
are also prone to covid;
obesity comes from being carb intolerant,
ie, not adapting well to the
chosen level of glycemic load.
. the problem with the Western diet
is that it has both a high glycemic load
and is high in fats and stress
that cause insulin resistance.
. if africs are more prone to insulin resistance,
they need to compensate by using less carb's.
20.11.30: web,aq.med/redcross/
health/immunity/covid-19/my covid-19 antibody test is negative:
summary:
. I got a covid-19 antibody test
from giving blood to the redcross;
and it came back negative,
but while that could mean I never got exposed,
it could also mean I had a mild case of covid-19
where my immune response made very few antibodies,
and within 8 months, I make undetectable levels.
