non-alcoholic fatty liver disease is very common #fructose #roundup

17.11.16: news.health/probiotic/hormonics/
non-alcoholic fatty liver disease:
2018.3.26: summary:
. surprised to learn how many are sick with
something that may be related to dysbiosis;
ie, having the wrong gut germs from a bad diet
or from getting too many antibiotics
such as the pesticide Roundup
(much more common in grains and legumes now).
. Dr.Rinella blames fatty liver on
bad germs or leaky gut and being obese,
but the primary cause is our modern diet
high in fructose (sugar is half fructose).
[J Hepatol. 2008]

Mary E. Rinella, MD:
jama 2015 june 9,
Nonalcoholic Fatty Liver Disease
A Systematic Review

Nonalcoholic fatty liver disease
affects approximately 30% of the US population.
p2266:
high visceral adipose tissue (being obese)
increases pro-inflammatory mediators
and excessive free fatty acids (lipotoxemia)
and insulin resistance;
all that affects the liver:
alterations of glucose and lipid metabolism.
. all that altered metabolism leads to
fatty liver or hepatic steatosis.

2nd stage is steatohepatitis
caused by lipotoxicity from increased free fatty acids
and by inflammation from
obesity releasing pro-inflammatory mediators,
and by intestinal dysbiosis generating portal endotoxin.
. pro-inflammatory mediators and
(endoplasmic reticulum sress
from dysregulated unfolded protein response)
leads to pro-inflammatory signalling
that along with (the vicious circle of
oxidative stress and mitochondrial dysfunction)
causes activation of hepatic stellate cells
and collagen deposition;
that leads to fibrosis
which is a precursor to cirrhosis.

. one symptom of insulin resistance is
acanthosis nigricans
[velvety darkening of the skin.
It is usually found in body folds.]

@MonsantoCo #roundup chronic low doses caused #kidney damage in rats

4.19: news.pol/healthcare/roundup/
chronic low doses might cause kidney damage:
summary:
. low-dose Roundup might cause kidney damage?
this had caught my eye because recently
I had blamed the increasing kidney damage on
dramatically increasing use of fructose;
but also there has been increasing use of Roundup
(it contaminates much of the water supply now;
it might even be your rain).
and this study says low-dose Roundup in rats
was associated with slow kidney damage
(occurring over years not months).
. tests for gmo's and their associated pesticides
are usually short term (eg, 90-day) studies,
whereas any damage may take several years.

gout #prevention #diet avoid #fructose

1.13: web.health/diet/gout prevention:
summary:
. an acquaintance thought oats worsen gout;
what is a diet that reduces gout risk?
. certain foods contain more purines,
which break down into uric acid,
that may form crystals in joints;
but gout doesn't correlate exactly with purines.
. fructose is metabolized into uric acid [JASN 2010].
. milk products may reduce risk despite purines;
but milk protein may be inflammatory due to Neu5Gc,
a sialic acid found in non-human mammal protein.

new normal sugar doubles heart disease risk

7: news.health/new normal sugar doubles heart disease risk:

. sugar has been shrugged off as merely fattening;
but, it can also lead to cardiovascular disease
as well as many other chronic diseases,
including diabetes mellitus,
liver cirrhosis[from fructose in sugar],
and dementia [from cholesterol raised by sugar]
— all linked to metabolic perturbations involving
dyslipidemia, hypertension, and insulin resistance .
. in the latest study (JAMA Internal Medicine, Feb 3),
added sugars were defined as
those used in processed or prepared foods,
including sugar-sweetened beverages,
packaged cereals and breads, etc;
but not those that occur naturally
in fruit and vegetables.
. sugar counted for at least 25% of the calories
among 10% of the group;
that group had a 2.75 times greater risk
of cardiovascular disease mortality
compared to an sugar intake of less than 10%.

#cancer grows in #fructose #HFCS #sweetsurprise

11.14: news.health/cancer/grows in fructose:
Cancer Res 2010:

. Synthesis of nucleic acids and nucleotides
is of utmost importance for proliferating tissues
and especially cancers.
. fructose's contribution to nucleic acid synthesis
is considerably greater than glucose;
and, cancer cells preferentially use fructose
via TKT-mediated metabolism
to synthesize additional nucleic acids
to facilitate increased proliferative capacity.
. previous studies have shown that
chronic fructose feeding in animals
leads to insulin resistance
and promotes in vivo growth,
as evidenced by increased organ weights
Additionally, in humans,
increased fructose consumption has been linked to
obesity, diabetes, and elevated uric acid levels,
the latter in keeping with our
in vitro metabolomic studies showing
increased fructose-directed nucleic acid synthesis
[ Metabolism. 1982, J Nutr. 1985].
We have recently shown 2.5-fold higher
serum fructose levels in pancreatic cancer patients
compared with healthy subjects;
furthermore, in healthy volunteers,
serum fructose level rose rapidly following
ingestion of a liquid fructose and glucose load,
and in contrast to glucose
that quickly returned to fasting levels,
serum fructose remained elevated for >2 hours,
suggesting that circulating human fructose levels
are unregulated in comparison with the
exquisite regulation of blood glucose  [ Pancreas 2009 ].

Dr.Sears`zone diet 1997 reviewed #hormonics

11.10..12, 16; 12.21..23:
health/hormonics/Dr.Sears`zone diet

. this is a collection of notes for the book:
Barry Sears. zone-perfect meals in minutes.
HarperCollins Publishers (1997)
isbn 0-06-039241-X
. it includes notes from other sources
in order to full explain Dr.Sears' work;
and there are some updates for obsolete material .

#fructose kidney damage short magnesium

10.17: news.health/kidney/fructose damage may be from magnesium deficiency:

"We showed that hypomagnesemia independently predicts
the progression to end stage renal disease
in patients with advanced type 2 diabetic nephropathy" .
"Our findings suggest that magnesium supplementation
may be renoprotective in this population."

[Diabetes Care 2012 Yusuke Sakaguchi]
-- this could be how fructose causes kidney damage:
it creates insulin resistance,
which in turn causes magnesium resistance .

#trehalose is not a #slowcarb !

12.1: health/hormonics/#trehalose is not a #slowcarb !:
. trehalose should be presented as
a healthy alternative to popular sugars
(which includes not only sucrose,
but also high-fructose corn syrup);
however,
the reason it is a better sweetener
is not because it is digested more slowly
but because it has no fructose
-- and nothing could be healthier
than ending the use of high-dose fructose .
. it also has some other health benefits .

trehalose is hardly a #slowcarb:

. when compared to pure glucose
its raising of blood sugar levels
is 33% lower than pure glucose,
(isn't that an index of 66? -- like bread!)
and the extent to which it raises insulin
is only 14% lower than pure glucose
-- that is hardly in the zone!

. also keep in mind the risks of
genetically modified foods;
trehalose comes from maltodextrins;*
and "most maltodextrin is manufactured from corn"
and of course,
USA corn is mostly GM (genetically modified) .
. I'm not sure anything is wrong with GM sugar
but I can't be sure about the dangers of GM
because the science is corrupted by Big Money,
-- and by Big Religion:
we need to keep feeding a population
that won't stop growing !

yeast infections love trehalose:
. after tsp/4 trehalose before bed,
I woke up with an inflamed mouth
which I understand was a mild yeast infection,
since I'm quite prone to that .

. but that could happen on trehalose itself,
not just the breakdown into glucose,
since the yeast Saccharomyces cerevisiae
can use trehalose as a carbon source for growth;
and, Candida albicans synthesizes Trehalose
in order to avoid stress-induced apoptosis,
so perhaps that yeast also can grow in trehalose .

. yeast is usually controlled by bacteria,
so I will mix the trehalose in my peas,
where I keep the probiotics .
. that will lower the glycemic index too!

* trehalose from maltodextrins:

"In 1994, two patents were issued by
Hayashibara Biochemical Laboratories Inc. (Okyama, Japan)
disclosing a novel non-reducing
saccharide forming enzyme
(maltooligosyl trehalose synthase,
MTSase; EC 5.4.99.15)
and a trehalose releasing enzyme
(maltooligosyl trehalose trehalohydrolase,
MTHase; EC 3.2.1.141)
obtainable from the culture of
microorganisms such as Rhizobiumsp. M-11
and Arthrobacter sp. Q 36 ...
The first enzyme acts on reducing maltodextrins
having a polymerisation degree (DP) higher than three
and catalyses the conversion of the α-1,4 linkage
at the reducing end to an α-1,1,
the second enzyme specifically acts on
the α-1,4 linkage adjacent to the α-1,1
liberating trehalose and a
lower molecular weight maltooligosaccharide
[ an oligosaccharide derived from glucose monomers
linked as in maltose;
maltose is converted to glucose by maltase.]
...
The enzymatic synthesis of trehalose
is currently obtained using the
MTSase and the MTHase described above
by Hayashibara Biochemical Laboratories Inc"

corn syrup without fructose

7.7: pol/healthcare/corn syrup has no reason
without the unhealthy high fructose:
. even though fructose is
more expensive and unhealthier,
if fructose weren't added,
then corn syrup would not be sweet,
and then you'd have no reason to
add the corn syrup itself
other than it being a cheaper source of calories,
which gets: "( huh, why I am eating
so many empty calories anyway?
it doesn't even taster better! )
-- still, it would be just as filling, [9.27:
and then it would make you hungrier later;
so, I'm sure your food processors
would continue to add corn syrup to everything
even if it didn't have sweetening fructose .]

found a loophole in Atkins 2002

7.20: health/hormonics/found a loophole in Atkins 2002:
. my familiarity with Atkins is limited to
a book he last revised in 2002;
in that book, he suggested that
in determining our carb' allotment,
we didn't need to count the non-insulinemics,
which includes fructose .
. the Zone diet noted that
one way to keep your blood sugar up,
is to get generous amounts of certain proteins
(chicken, fish, egg whites, veg protein isolate,
but not whey protein isolate).
. Dr.Lustig noted that a leading cause of
the liver becoming insulin resistant
is from eating too much fructose;
he also warned us that it was the
combination of glucose provoking insulin
and fructose causing insulin resistance
that was causing the current epidemic of
metabolic syndrome (obesity, fatty liver, ...).
. some with high blood sugar are finding that
their blood sugar is high on awakening
suggesting that for some reason
their liver is being fooled into making
too much glucose .
. one way it can be fooled is insulin resistance:
as it produces glucose,
it knows when to stop because
it detects that levels of insulin are getting high;
but if it's insulin resistant,
it can't hear the insulin signal
and thus continues to produce glucose
even when the {insulin, glucose} are too high .
. therefore,
high glycemics is not exactly the whole problem:
fructose is making the liver insulin-resistant
which makes the liver put out too much glucose;
so, if instead of sugar you had too much
combined fructose and protein,
that too would cause the same hyperglycemia,
without being on a high -glycemic diet ?
. if that 's true,
that's a loophole in the Atkins 2002 diet,
because he allows non-insulinemic carb's
and any amount of any sort of protein .
. most people don't fall into that pitfall
only because fructose is usually combined with
the insulinemic carb's that Atkins controls,
so most on Atkins diet tend to get less of
all sorts of carb's, including fructose .

calcium supp's cause arterial calcifications?

5.9: web,mis.health/
when do calcium supps cause arterial calcifications?:

. I had erroneously assumed that the
routine finding of arterial calcification in elders
was being made worse by the advice
to take calcium to fight bone resorption .

. calcification is a problem,
but in the calcium deficient test animal,
calcium-supp'ing, reduced calcification by 62%;
because,
when there's a deficit of calcium in the blood,
 the body excessively releases bone calcium
[20. Sanders S, Debuse M. 2003:89-90.]
and saturates soft tissues with calcium .

. so, could there be a bell curve effect,
where a deficit of calcium does
 flood the system with bone calcium,
but likewise, if you're taking megadoses of calcium,
that would have the same effect as low calcium?

. in any case, there is a study showing that
calcium supp's do increase the risk
of heart attacks by 27%;
and, lef.org points out the study's special conditions:
the risk from calcium is eliminated by
combining the calcium with sufficient levels of
calcium controlers (vit'd, vit'k, magnesium).
. not only does vit'k keep calcium in bones,
it has some way of keeping it off arterial walls,
[5.10: likely by making it latch onto more useful things,
that happen to be closer by .]

5.10: depends on form:
. certain forms of vitamin D are provoking bone resorption:
25-hydroxycholecalciferol
vs 1,25-dihydroxycholecalciferol
In 10 patients taking oral 0.25 micrograms of
1,25-dihydroxycholecalciferol twice daily for 7 d,
--[ Rocaltrol Oral Suspension (calcitriol) Rx ]--
calcium absorption increased more than in 10 patients taking
oral 40 micrograms of
25-hydroxycholecalciferol once daily for 7 d (p less than 0.02)
--[ the common D3 found in most supplements ]--
despite both groups having a
similar increase in plasma 1,25-(OH)2D.
These results support the view that the major effects of
oral 1,25-dihydroxycholecalciferol on absorption
is due to a local action on the gut
and that it is possible to increase
calcium absorption in osteoporosis
with oral 1,25-dihydroxycholecalciferol
without increasing its undesirable action on bone resorption.

6.5: may depend on dosing too:
. the form provoking the bone resorption
is also the most common form by far;
so maybe it would still be safer if
the dose was divided and taken with calcium ?
but too much calcium
inhibits conversion to the active form:

The following inhibit the activity of 1-hydroxylase enzyme
needed for making active vitamin D (calcitriol):
    # low parathyroid hormone (PTH)
     - PTH stimulates 1-hydroxylase.
     [see how common low PTH is, and what to do about it]
    # High calcium levels cause lowered PTH .
    # High phosphorus intake/high blood phosphorus.
    (An aside: Fructose we eat gets phosphorylated,
    grabbing phosphorus and holding it in the liver.
    So fructose (fruit) consumption can counter
    high phosphorus intake(dairy, fish, meat, soda) .)
    [don't mix high fructose with high-glycemic diet]
    # High concentrations of calcitriol
    - A negative feedback mechanism is in play, meaning,
    the more active vitamin D you have circulating,
the less active the enzyme.

. the Active vitamin D, also called calcitriol,
is a high-energy, twice-hydroxylated compound
with a very short half-life (about 5 hours)
- such that levels of active vitamin D are tightly controlled .
Serum concentrations of active vitamin D (calcitriol)
are not typically correlated with vitamin D intake,
or vitamin D stored as 25(OH)D3.
It is primarily calcitriol that is responsible for the
benefits we're discovering about this vitamin,
e.g. mineral balance and bone mineralization,
immunity, blood pressure control,
reduction in cancer cell proliferation, and insulin secretion.

list of calcitriol suppliers .
(CAS NO.     32222-06-3; 125338-24-1)

#hypertension is from #sugar not #salt #health

2011.{11..12}.1: health/hypertension
2012: summary:
. hypertension is not caused by excessive salt;
but rather by a high-glycemic diet
that provokes too much insulin
which is then disabling the kidneys
by preventing them from removing salt .
. another factor is arterial tension
that is controlled by magnesium .
. here again, insulin abuse is the culprit,
causing magnesium resistance,
requiring higher doses to the same job .
. high amounts of dietary fructose
can be another source of high blood pressure .
. some salty seaweed seems to have
little effect on pressure;
that's because the pressure problem comes only from
the kidney's inability to clear sodium chloride;
whereas some seaweed has no chloride:
its sodium comes in the form bound to proteins .
. Wrack seaweed is a great source of minerals
and is safe for those with high blood pressure .
. conversely,
higher levels of dietary fructose from added sugars
are responsible for not only high blood pressure,
but an epidemic of kidney disease .

The Shangri-La #Diet debate replays #Atkins

2011.11.9: web.health/diet/shangrila diet:
[2012.1.17: summary of news:
.  psychologist professor Seth Roberts
had written The Shangri-La Diet:
The No Hunger Eat Anything
Weight Loss Plan (2006)
. the point of the title is that
the book was not so much about dieting
as it was about retaining your dieting results
by the use of associative learning theory
for lowering your Body-Fat Set Point .
. having some personal anecdotal evidence,
he wrote the book to ask the public
if they would like to join an online experiment
(Shangri-La Diet forums at sethroberts.net).
. Dr.Ford accused him of abusing his professional title:

"( Dr. Roberts has not been shy or circumspect about
touting his credentials as an
associate professor at University of California, Berkeley.
However, despite his status as an academic,
he has opted to bypass his own colleagues
and the checks and balances of his own profession.
Rather he chose to go straight to the lay press.
Obviously by mentioning his university affiliation,
he intended to give the added weight to his conclusions
that such a position would appear to justify.
Why wouldn't he have studied his diet
the way researchers normally do
when they want to establish the validity of a hypothesis
(and I don't mean with a sample size of one)
before publishing widely? .)]

my reaction to Dr.Ford:
. what is the point of science?
pretty spendy isn't it?
you hear about $millions involved .
. and of course, "(the quacks always say that!)
-- and also predictably,
the quacks point out that if you follow the money
there is a conspiracy between FDA, BigPharma,
and Medical professionals (Doctors, Consultants, ...) .
. it might even seem true when you find out
BigPharma essentially funds the FDA
-- essentially funding your own watchdog?!
. and Doctors don't look too saintly either
with their medical cartel artificially creating
a shortage of doctors to keep their wages high .
. yet quacks make outlandish claims,
and there is a good reason for quackwatch;

but then I watched them take down Dr.Atkins,
despite his referencing good science
-- science that did apply to his program .
( well, I didn't read Atkins' first book ...
let's assume he was always well-referenced: )

#gov nutrition label for allergenic #gmo:

proj.pol/gmo/#gov nutrition label for allergenic #gmo:
Subject: Docket No. FDA-2011-P-0723
U.S. Food and Drug Administration
President Barack Obama
(emailed by gefoodlabels.org)
. I write in support of the Center for Food Safety's
Legal Petition to FDA to Require Labeling
of Genetically Engineered Foods
(Docket No. FDA-2011-P-0723).
FDA believes that GE foods are
“of the same or equal quality”?
how can random shifts in genetic code
not create inequal amounts of
random new proteins,
including allergens ?! this is appalling .
. if you put it on the label,
then people who think they have allergies
can try non-gm and see it was gm .
. that nutrition label needs an upgrade anyway:
you need the food's glycemic index,
glycemic load, and the amount of
any sugars that require liver processing,
especially fructose .

missing the forest for the sugar trees

8.1: health/zone/Lustig/missing the forest for the sugar trees,

. this is a recap of the Dr.Lustig-coach debates .
. please note that while writing the following,
I was trying to understand a coach's view
without having any experience at being one;
if you'd like a good coach;
to learn how sugars can be your friend
see Dr.Lustig's debaters, Aragon and Hale:
. they have publications for not only
strength training and obesity control
but also how to do good health research:
#  Alan Aragon's Research Review
# Aragon . Girth Control:
The Science of Fat Loss & Muscle Gain
. Jamie Hale's publications:
# Knowledge and Nonsense,
  including Nutrition: Fact or Fiction
# MAXCONDITION
# Protein Essentials
# The Carbohydrate Files
. both appear on jpfitness.com's Nutrition forum:
# Hale has corrected Sugar Obesity myths
(notice the chiseled torso),
# Hale interviews Aragon,
# Aragon answers a question about subscriptions .

. in the debate with Dr.Lustig,
the coaches who defended simple sugars,
and esp'ly fructose,
were not sympathetic to Lustig's main point:
. not everyone has good coaches,
and they are getting caught in food abuse .
. it doesn't help a cocaine addict
to know that Dr.Freud could use responsibly;
what is most relevant here is
whether sugar is an abusable substance,
and can we do anything to curb abuse?

. the coaches certainly have a good reason
for supporting proper use of simple sugars:
there can be great gains in muscle-building
from the pulsing of insulin* and IGF
(insulin-like growth factor)
by properly applying the combination:
# whey or branched chain amino acids
(an insulin resistor and growth food)
# simple sugars (including both
the insulin-provoking glucose,
and the insulin-resisting fructose).
*(however, Aragon has reservations).

. some have even noted that proper pulsing
can increase testosterone levels
(testosterone can rise with insulin resistance),
while improper use that results in obesity
can lower testosterone
(converting it to estrogen).

. to get the proper effect from sugars
you need to be initially healthy,
with good insulin sensitivity,
assisted by peak resistance training,
or aerobic exercise,
and possibly fasting beforehand .

7.19: proper respect for context:
. chiseled fat-free bodybuilding
may depend on a chemistry
that can speed recovery without adding fat,
and that means refilling the liver's glycogen quickly
without having to worry about high glucose levels .
. for the most part, safe handling of glucose
means leaving it up to glycogen conversions,
and, on an empty liver (without glycogen)
fructose quickly provides this glycogen
because when empty,
the liver prefers converting fructose to
glycogen rather than to triglyceride .

. the general public is neither
pulsing their simple sugars properly
nor into peak-resistance exercising;
and, the sugar they use
is typically going straight to triglyceride!
. Dr.Lustig has linked abuse of sugar
to metabolic syndrome and obesity;
. Gary Taubes has linked cancer with
metabolic syndrome and obesity .

fructose | Chlorella is an antidote

7.24: news.health/fructose/Chlorella is an antidote:

. Chlorella is a nutritious
fresh water algae,
popular in Japan and Taiwan
that may reduce Insulin resistance
when used daily in several meals .
. the #1 cause of insulin resistance
is excessive fructose consumption,
according to Dr.Mercola,
referring to the modern diet high in
added fructose+glucose sweeteners .
. a rats-on-fructose-diet study showed
that chlorella undid some of the fructose's
insulin resistance .

safe-carb's Dr.Lustig

7.26: health/zone/safe-carb's Dr.Lustig

reincarnation of saint Atkins found!

. the spirit of Dr.atkins
was the same as Jesus Christ:
going against the established culture
to make big improvements for even the least of us .
. his particular achievement was to reveal
that, contrary to conventional medical advice,
a high fat diet was actually
safer for your heart than a
low-fat, normal-carb diet;
-- at least when you were
obese and insulin resistant --
because, among the insulin resistant
there is carb intolerance,
so that what seems like normal carb intake
is actually perpetuating
insulin resistance and high insulin
-- by far the highest risk factors
for heart disease;
he also revealed that for those who were
highly insulin resistant,
a zero-carb diet was essential to
getting back your insulin sensitivity,
and getting back into fat-burning mode .

born-again conservative with Congressman Aaron Schock

5.10: news.pol/born-again conservative with
Congressman Aaron Schock:
Men's Health magazine/The Ripped Representative
America's Fittest Congressman:
The Aaron Schock Workout & Summer Challenge

you want to subsidize corn and healthcare?!

1.17: web.health/glycemic index of various corn products:
65 Sweet corn, (has fiber and germ)
70 corn flour (same as sucrose)
85 corn starch (same as white bread)
-- the de-germed flour of the corn kernel
115 corn syrup --[ higher than 100 indicates a toxin .
   . it's measuring the rise in blood glucose
with pure glucose assigned an index of 100;
if the rise is faster than glucose,
it means something in it
is preventing cells from using it,
thereby keeping it dammed in the blood stream .]
70 high-fructose corn syrup drinks, hfcs sodas
--[ should be 115:
this is corn syrup with fructose added;
while the glycemic index appears low
it's because they testing a dilution .
. fructose doesn't become glucose
so it has a zero glycemic index;
but it does turn into triglycerides
that are making glucose less easy to use .
. by diluting the corn syrup
there's less of it test;
whereas the usefulness of the test
is not in showing how much a given calorie load
will turn into a given blood sugar load,
but rather,
in giving an idea of how fast
the blood sugar is increasing
-- important because the body can
put out insulin only so fast,
and if it can't keep up with that soda,
then there are short bursts of
brain-damaging high blood sugar;
in its rush to catch up, the insulin overcompensates:
bringing the blood sugar too low,
then the system protects itself from low brain sugar
by using cortisol to make the body insulin resistant
so there will be more for the brain;
at the next can of soda,
this insulin resistance will make the problem worse .]

why teens have elderly cholesterol levels

1.22: news.health/cancer/teen cholesterol:
One-fifth of US teens have unhealthy cholesterol

Thu Jan 21, 2010 4:15pm EST
(Corrects AAP recommendations in fifth and sixth paragraphs)
WASHINGTON (Reuters)
- One in five American teens has unhealthy cholesterol levels,
a major risk factor for heart disease in adults,
the U.S. Centers for Disease Control and Prevention said on Thursday.
The heavier teens were,
the more likely they were to have high cholesterol
but even 14 percent of teens with normal body weight
were found to have unhealthy cholesterol levels, the CDC said.
CDC researchers studied data on 3,125 teens
collected from the
National Health and Nutrition Examination Survey
for 1999 through 2006.
They found that 20.3 percent of young people aged 12 to 19
and more boys than girls
had unhealthy cholesterol levels.

[ . high fructose corn syrup can raise triglycerides
and promotes fungal overgrowth
which is known to raise bad cholesterol .]