Showing posts with label diet. Show all posts
Showing posts with label diet. Show all posts

2023-05-12

vegetables having bitter anti-cancer goodness bred out of them

 2023.5.12: news.health/diet/
vegetables having bitter anti-cancer goodness bred out of them:

. when you hear that certain foods have anti-cancer effects,

consider that some are trying to breed sweeter vegetables

that could reduce their anti-cancer effects.


. many brussel sprouts have been bred to have less

bitter glucosinolates, which made them more popular.

https://twitter.com/scifri/status/1657085545338531840

https://www.sciencefriday.com/segments/otc-birth-control-pill/#segment-transcript


. glucosinolates are known for beneficial effects including 

regulation of inflammation, stress response, 

and phase I metabolism.

Glucosinolates that combine with myrosinase, 

can become an anti-cancer isothiocyanate.

. foods with high glucosinolates 

should not be the primary source of energy

because heavy doses can result in goiter, anemia, 

organ lesions, and reduced growth.

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/glucosinolate


. in what other ways are healthy fruits and vegetable

made less healthy or anti-cancer by breeding that makes them 

sweeter or less bitter?




2023-03-02

low-dose aspirin seems good for eyes except with vitamins

2023.3.2: web.health/diet/aspirin/blindness/

low-dose aspirin seems good for eyes except with vitamins:

summary:

. there are some studies that seemed to show

that aspirin increased your risk of blindness;

but the best type of study (randomized trials)

showed they actually reduced the risk of blindness

unless you happen to be the user of multivitamins.

. one study showed that only people with good genes

 may benefit from a good diet;

but you should be safe from AMD blindness if you

limit both omega-6 vegetable oils and your glycemic load.

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C3&q=omega-6+%2C+amd+blindness


Ophthalmology. 2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875604/

The association of aspirin use with

age-related macular degeneration progression 

in the Age-Related Eye Disease Studies: AREDS2 Report No. 20.

. there are 2 randomized clinical trials:

Arch Ophthalmol. 2001: 

Age-related maculopathy in a randomized trial of low-dose aspirin among US physicians. 

Ophthalmology. 2009:

Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women. 


. using 100mg aspirin every other day

slightly reduced your risk of AMD

yet increased your risk if you used certain multivitamin supplements.

"Among current nonusers of multivitamins, 

those in the aspirin group had a statistically-significant

32% reduced risk of AMD (HR, 0.68; 95% CI, 0.49−0.95) 

whereas among current users of multivitamins, 

there was a nonsignificant 14% increased risk of AMD 

in the aspirin group (HR, 1.14; 95% CI, 0.76−1.70)"

[ Ophthalmology. 2009

https://pubmed.ncbi.nlm.nih.gov/19815293/

Low-Dose Aspirin and Medical Record Confirmed

Age-related Macular Degeneration in a Randomized Trial of Women;

William G. Christen, Sc.D, et al.]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787838/


"men assigned to alternate-day low-dose aspirin (325 mg) 

had a statistically non-significant 

22% reduced risk of visually-significant AMD 

during a five year treatment period."

. placebo terminated early due to aspirin causing

a 44% reduced risk of first myocardial infarction.

[ Arch Ophthalmol. 2001

https://pubmed.ncbi.nlm.nih.gov/11483080/

Age-related maculopathy in a randomized trial of

low-dose aspirin among US physicians;

W G Christen et al.]


"In AREDS, both aMedi[Mediterranean-type diet] and its fish component

interacted with CFH rs10922109 for late AMD

(P = 0.01 and P = 0.0005, respectively); 

higher aMedi and fish intake were each associated with 

decreased risk of AMD only in participants with protective alleles. 

Closer adherence to a Mediterranean-type diet 

was associated with lower risk of progression to late AMD and to large drusen. 

The signal was greater for GA than neovascular AMD. 

Fish intake contributed to this protective association. 

CFH genotype strongly influenced these relationships. 

Hazard ratios (HRs) for progression in aMedi tertile 3 versus 1 

were 0.78 (95% confidence interval [CI], 0.71-0.85, P < 0.0001) 

for late AMD, 0.71 (0.63-0.80, P < 0.0001) for GA, 

and 0.84 (0.75-0.95, P = 0.005) for neovascular AMD. 

For fish consumption, HRs for late AMD in quartile 4 versus 1 were

0.69 (0.58-0.82, P < 0.0001; AREDS) and 

0.92 (0.78-1.07, P = 0.28; AREDS2). 

. the HR for progression to large drusen in aMedi tertile 3 versus 1 was 

0.79 (0.68-0.93, P = 0.004)."

[ Ophthalmology. 2020

https://pubmed.ncbi.nlm.nih.gov/32348832/

Adherence to the Mediterranean Diet and Progression to

Late Age-Related Macular Degeneration 

in the Age-Related Eye Disease Studies 1 and 2;

TiarnĂ¡n D Keenan, et al;

Age-Related Eye Disease Studies (AREDS) 1 and 2 Research Groups.]

Dr. Barry Sears 2002`The Omega Rx Zone:[ad]
The Miracle of the New High-Dose Fish Oil

The Mediterranean Zone: [ad] 
Unleash the Power of the World's Healthiest Diet for Superior Weight Loss, Health, and Longevity Hardcover – 2014 by Dr. Barry Sears (Author)


 

2023-01-22

metformin for preventing blindness #amd #health #blindness #metformin

2023.1.22: news.health/diet/blindness/amd/metformin:

. if your blood sugar is borderline high,

then you might be a candidate for taking metformin;

that drug is now known to reduce the risk of blindness

by inhibiting retina death (geographic atrophy)

and by inhibiting intraocular neovascularization (wet AMD).

Int J Ophthalmol. 2021 Aug:

https://pubmed.ncbi.nlm.nih.gov/34414094/

Newly-found functions of metformin 

for the prevention and treatment of age-related macular degeneration;

Kuan-Rong Dang, Tong Wu, Yan-Nian Hui, Hong-Jun Du.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342286/


2022-10-21

skinless chicken has an omega-6 load similar to a single yolk

 2022.10.21: web.health/diet/omega-6/
skinless chicken has an omega-6 load similar to a single yolk:

. an egg's worth of arachidonic omega-6

will prevent fish oil from causing bleeding disorders,

but too much may increase clotting disorders,

and contribute to inflammation.

. skinless chicken has an omega-6 load 

similar to a single yolk:

2022-10-19

Simplify Your Health by Dr. Lucas Ramirez 2022

 22.10.15..19: bk.health/diet/Dr. Lucas Ramirez 2022`Simplify Your Health

. this is a commentary on the book of

vascular neurology Dr. Lucas Ramirez 2022:

Simplify Your Health: A Doctor's Practical Guide to a Healthier Life 

https://amzn.to/3Tkvf7Y[ad]

4-star/great advice ..and battling "misinformation":

2022-10-16

methyl salicylate on mucous membranes

 20.10.16: health/diet/methyl salicylate on mucous membranes:

. one can get a cleaner toilet wipe by adding alcohol to the paper.

. alcohol may raise the risk of cancer,

but there may be less risk with salicylates added,

hence the use of alcohol with methyl salicylate.

. is it safe to rub methyl salicylate on mucous membranes?

it is absorbed even through skin where it supposed to be used,

and is added to food as a flavoring.

2022-09-15

Chuck Norris anti-aging diet

2022.9.15: health/diet/Chuck Norris anti-aging diet:

Chuck's 3 keys to healthy aging:

1: healthy microbiome: 

needs probiotics and prebiotics

(onion and Jerusalem artichoke inulin)

2: superfoods: barley grass, kale, alfalfa.

3: rapid aging fix: ashwagandha,
and bovine collagen peptides.

2022-08-22

bone and muscle boosters

 2022.8.22: health/diet/osteo/hormonics/
bone and muscle boosters:

. one of the best things you can do for bones

is getting vitamin k2 to keep the calcium 

from being pulled out of bones by vitamin D.

Vitamin K2 doses need to much higher than vitamin K1 doses,

and I found only one supplement that provides a dose

proven effective in studies:

Life Extension Mega Vitamin k2, 45,000 micrograms of the mk4 form of K2.

https://www.lifeextension.com/vitamins-supplements/item02417/mega-vitamin-k2-high-potency-for-strong-bones

2022-06-20

regenerative farming for mycelium for ergothioneine #health #diet

 2022.6.20: news.health/diet/ergothioneine/regenerative farming for mycelium:

summary:

. regenerative farming means not tilling the soil;

not tilling preserves the fungal biomass of the top soil;

fungal biomass is our primary source of ergothioneine,

an amino acid related to histidine,

which is taken up by the plants we grow in fungal soil,

and then taken up by the animals that eat those plants.

. ergothioneine may be reducing our risk of Alzheimer's,

possibly by protecting mitochondrial function.

. the beef from a regenerative farm also had 

a higher ratio of omega-3 to omega-6.

2022-06-06

lowering vegf helps #amd? several herbs lower vegf #health #diet

 22.6.6: web.health/diet/blindness/amd/

lowering vegf helps amd? several herbs lower vegf:


summary:

. several methods of cancer treatment

are anti-angiogenic: they work by

stopping new blood vessel growth.

. one thing that cancers and amd blindness

have in common, is excess production of vegf

(vascular endothelial growth factor)

that causes the rapid growth of blood vessels

that tend to be leaky and result in edema.

. for wet amd (age-related macular degeneration

with high vegf that results in leaks and edema)

the only anti-vegf treatments have been injections

that are very expensive and can be painful.

. several herb are known to lower vegf,

and I wondered if taking them orally

could lower vegf in the eye.

2022-05-23

more orange yolk means less AMD blindness

2022.5.23: health/diet/egg/blindness/
more orange yolk means less AMD blindness:

summary:

. a yolk that is more orange (than yellow)

is likely to have more lutein and zeaxanthin

that reduces the risk of AMD blindness.

. organic eggs have rules about

the coloring additives added to chicken feed.

. if you are not certain about the quality

of the coloring in your egg,

you can supplement with zeaxanthin and lutein.

[eg, MacuGuard® Ocular Support with Saffron:

https://www.lifeextension.com/vitamins-supplements/item01992/macuguard-ocular-support-with-saffron

10 mg free lutein, 

4 mg meso-zeaxanthin & trans-zeaxanthin.]

. taking the supplement with yolk

might increase its bioavailability

because MacuGuard claims to use Phospholipids

in order to enhance lutein absorption,

and egg yolk contains Phospholipids.

[ Nutrients. 2015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425170/

Egg Phospholipids and Cardiovascular Health.

Christopher N. Blesso]

2022-04-10

does copper improve or worsen schizophrenia?

2022.4.10: psy/schiz/diet/copper/
does copper improve or worsen schizophrenia?

summary:

. it was found in 1959 that ceruloplasmin, which carries copper,

could improve psychotic symptoms in many schiz'ics.

. however, it was also found that some measure of copper

is elevated in schiz'ia,

or in any condition causing chronic stress or fear.

. ceruloplasmin is used as a measure of copper

because 95% of blood copper is in ceruloplasmin

but ceruloplasmin is an acute phase reactant, 

increased during inflammation, infection, trauma, pregnancy, etc. 

. some who are assuming that copper is a cause of schiz'ia

are theorizing that ceruloplasmin may be 

catalyzing the oxidation of epinephrine 

to some psychosis-inducing indole-like material.

. but if ceruloplasmin can improve psychotic symptoms,

it is likely that the rises in ceruloplasmin 

are a reaction to the stress of schiz'ia,

and not the cause of it.

2022-04-06

use of a bisphosphonate Fosamax (alendronate sodium) vs vitamin k2 (mk-4)

2022.4.6: health/diet/vit'k2/med/osteo/

use of a bisphosphonate Fosamax (alendronate sodium) vs vitamin k2 (mk-4):

summary:

. some studies show that the bisphosphonate 

Fosamax (alendronate sodium)

is not really helpful,and risks might include 

atrial fibrillation, but the evidence is conflicting.

. meanwhile, a study of vitamin k2 (mk-4)

was so effective it was hard to believe!

2022-03-29

to optimize a boy's IQ, avoid fluoridated water during pregnancy

2022.3.29: news.health/diet/fluoride/
to optimize a boy's IQ, avoid fluoridated water during pregnancy

. a lower IQ is what makes lead so dangerous,

increasing risky behaviors.

. if your region's water has high or added fluoride,

drinking that water while pregnant with a boy

will lower that boy's IQ.

tea is another major source of fluoride.

. this is not a call to end water fluoridation,

but to drink pure water during pregnancy.

2022-03-09

chronic illness increased after oils of soy, grain, and seeds added to diet

 2022.3.9: health/diet/omega-6/

chronic illness increased after oils of soy, grain, and seeds added to diet:

Dr. Chris Knobbe warns us that we are wrong about

omega-6 oil being healthy at higher doses.

AncestryFoundation 2021

https://www.youtube.com/watch?v=sKR1ZdHXXzo

Omega-6 Apocalypse 2 (AHS21)


Catherine Shanahan M.D. 2018: [ad]

http://www.amazon.com/dp/B01G1J7WEU/ref=nosim?tag=americiu-20

Deep Nutrition: Why Your Genes Need Traditional Food. 

2022-02-08

fish oil reduces risk except for angina patients

22.1.2:  2.8: news.health/diet/omega-3/heart
/fish oil reduces risk except for angina patients:

Mayo Clin Proc. 2021 Feb

https://pubmed.ncbi.nlm.nih.gov/32951855/

Effect of Omega-3 Dosage on Cardiovascular Outcomes: 

An Updated Meta-Analysis and Meta-Regression of Interventional Trials.

Aldo A Bernasconi, et al.

commentary:

www.sciencedaily.com/releases/2020/09/200917084102.htm 

"People should consider the benefits of omega-3 supplements,

at doses of 1000 to 2000 mg per day

-- far higher than what is typical, 

even among people who regularly eat fish."

2021-10-25

Cares Act 2020 required removing guaifenesin from asthma meds

 21.7.12: web.health/diet/

Cares Act 2020 required removing guaifenesin from asthma meds:

. why was primatene recalled?

a competitor claimed that the Cares Act 2020

required removing guaifenesin;

possibly due to it being known that

guaifenesin may cause birth defects.

but that was known at least as far back as 2003.

[ Am Fam Physician. 2003:

https://pubmed.ncbi.nlm.nih.gov/12825840/

Over-the-counter medications in pregnancy

Ronald A Black, D Ashley Hill.

https://www.aafp.org/afp/2003/0615/p2517.html

]

2021-10-05

Berberine prevents heart failure through endothelial and calcium function

 2021.8.9: 9.4: health/diet/heart/Berberine/
prevents heart failure through endothelial and calcium function:

GreenMedInfo Research Group July 30th 2021

https://www.greenmedinfo.com/blog/seven-herbs-and-supplements-heart-failure


. something extracted from berberine

is blocking calcium influx, thereby reducing

the risk of heart failure.


Acta Pharmacol Sin. 2010

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002834/

Min-you Qi, Yu Feng, De-zai Dai, Na Li, Yu-si Cheng, Yin Dai. 

CPU86017, a berberine derivative, attenuates cardiac failure

through normalizing calcium leakage 

and downregulated phospholamban 

and exerting antioxidant activity. 


Front Physiol. 2020

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546405/

Miyesaier Abudureyimu, Wenjun Yu, et al.

Berberine Promotes Cardiac Function by 

Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure. 


. enhancing endothelial function helps heart:

Cardiovasc Drug Rev. 2001 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999047/

C W Lau, X Q Yao, Z Y Chen, W H Ko, Y Huang. 

Cardiovascular actions of berberine. 

. "Endothelial dysfunction is an important early event in the

pathogenesis of atherosclerosis. 

The mechanisms underlying endothelial injury are numerous

and linked to metabolic alteration. 

In obesity and insulin resistance, 

the increased secretion of proinflammatory cytokines 

and decreased secretion of adiponectine, 

the increased circulating levels of free fatty acids, 

and hyperglycaemia may alter gene expression and cell signalling in the vascular endothelium, 

contributing to changes in the release of endothelium derived factors. 

Dysfunctional endothelium is characterized by activation of NADPH oxidase, 

uncoupling of endothelial nitric oxide synthase (eNOS), 

increased expression of endothelin-1, 

an imbalance between the production of vasodilators and vasoconstrictor mediators, 

and induction of adhesion molecules

[31]. 

The altered endothelial homeostasis, in turn, 

contributes to plaque initiation and progression. 

It is associated with most cardiovascular disease, such as 

hypertension, coronary artery disease, chronic heart failure, 

peripheral artery disease, diabetes and chronic renal failure

[32]. 

Endothelial cells exposed to hypercholesterolemia show a 

reduced capacity to release endothelium-derived relaxing factors, 

because of LDLc promotion of endothelial eNOS downregulation

[33]. 

Lowering cholesterol levels appears to improve endothelial function

[34]. 

In diabetes and insulin resistance, other mechanisms may trigger endothelial dysfunction. 

Insulin signalling is altered in these two conditions, 

and affects the pathway leading to phosphorylation and activation of eNOS, 

which is also, in this case, dramatically downregulated

[35]. 

eNOS represents a major weapon of endothelial cells to fight vascular disease. 

It generates nitric oxide (NO), whose role is to dilate blood vessels

and maintain vascular homeostasis by stimulating cGMP

[36]. 

Several studies have suggested a central role of endothelial AMPK

in maintaining physiological functions, such as

mediation of eNOS activation in response to shear stress

[37], 

modulation of endothelial cell energy supply

[38], 

protection from apoptosis

[39] 

and regulation of inflammation, angiogenesis, and maintenance of perfusion

[40,41]. 

Impairment of endothelium dependent relaxation (EDR) 

represents reduced eNOS derived NO bioavailability, 

and is the first step in endothelial injury. 

It is present also in the absence of vessel damage. 

In 2000, Ko et al[42], by in vitro investigation, 

demonstrated that BBR has not only vasorelaxant 

but also antiproliferative effects. 

According to their results, BBR could act both on the endothelium 

and on the underlying vascular smooth muscle cells to induce relaxation 

(Figure (Figure1).1). 

NO, is likely involved in the EDR. 

More recently, this mechanism has been clarified in endothelial cells isolated from rat. 

It was confirmed that the vasodilatant effect of BBR

was mediated by eNOS leading to NO production 

through activation of the AMPK cascade. 

Moreover, BBR counteracts several adverse effects of hyperglycemia on the endothelium, 

including the inhibition of high glucose-induced reactive species 

intracellular accumulation and cellular apoptosis and inflammation, 

which characterize vascular injury

[31,43]. 

Another recognized effect of BBR is the significant decrease in

the number of adherent monocytes on endothelial cells, 

which is a key event in the early stages of atherosclerosis. 

Furthermore, BBR suppresses the activation of the 

nuclear factor-κB (NF-κB), 

the expression of adhesion molecules (VCAM-1 and ICAM-1) 

induced by hyperglycemia

and the high glucose-induced elevation of several pro-inflammatory cytokines and chemokines, 

including tumor necrosis factor-α, IL1-β, IL8 and MCP1, 

which are other targets of NF-κB 

involved in the development of atherosclerotic plaques

[43]"

fig 1:

. Berberine enhances endothelial function 3 ways:

it affects AMPK (Adenosine mono-phosphate kinase)

that affects eNOS (Endothelial nitric oxide synthase);

it lowers LDL-cholesterol and triglycerides;

and, it improves insulin sensitivity.


enzymedica Berberine 60 /$20.62

https://www.lifeextension.com/vitamins-supplements/item53349/berberine

Enteric-coated to prevent self-aggregation and formation of berberine crystals that reduce absorption.

Enzymedica's Berberine is provided in a

targeted delivery capsule 

to prevent release of berberine in the stomach. 

since in an acidic environment, berberine will bind with other berberine molecules

to form insoluble complexes that do not get absorbed. 

Prevention of the formation of these complexes

may improve the absorption of berberine.

Amount Per Serving

Berberine HCI (97%) (from berberis vulgaris extract) (seed) 500 mg

Leucine 50 mg

Other Ingredients: 100% vegetarian capsule (cellulose, gellan gum, water), 

rice concentrate, calcium laurate

[Calcium laurate helps powders flow into capsules 

and holds those powders together.]


Dr. Michael Murray:

https://www.iherb.com/pr/enzymedica-berberine-60-capsules/81507

"Berberine is commonly harvested from the flesh, roots or bark of plants 

like barberry, goldenseal and Oregon grape. 

Unlike many other formulas, this product is sustainably sourced from 

barberry seeds and does not require the plant to be sacrificed in its production.


sublingual instead of enteric coated?


Nutricology, Berberine 500, 90

https://www.iherb.com/pr/nutricology-berberine-500-90-vegetarian-capsules/82073

Hydroxypropyl methylcellulose, 

Nu-MAG® (rice extract, rice hulls, gum arabic, sunflower oil), 

silicon dioxide, microcrystalline cellulose.

https://ribus.com/nu-mag/

Nu-MAG offers formulators a Certified Organic alternative to Magnesium Stearate, 

so organic tablets requiring a lubricant can now be produced. 


Thorne Research, Berbercap, 60 

https://www.iherb.com/pr/thorne-research-berbercap-60-capsules/18577

Microcrystalline cellulose, leucine, silicon dioxide.

Berberis concentrate berberine HCl 85%.

Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata) 200 mg


Whitaker Nutrition, Clinical Grade, Berberine, 90 Capsule

https://www.iherb.com/pr/whitaker-nutrition-clinical-grade-berberine-1-500-mg-90-capsules/101131

Berberine Hydrochloride (BerberPure™) 500 mg (take 3)

Microcrystalline cellulose, gelatin, magnesium stearate, gum acacia, silica. 

2021-09-15

slow-carb fish eaters less prone to severe covid

 2021.9.15: health/immunity/covid-19/diet/
slow-carb fish eaters less prone to severe covid:

Jordi Merino, PhD:

https://www.sciencedaily.com/releases/2021/09/210908180530.htm

"Our models estimate that nearly a 

third of COVID-19 cases would have

been prevented if one of two exposures

-- [uhealthy] diet or deprivation -- 

were not present." 

2021-05-18

high fat vs high carb diet improves omega-3 vs 6 ratio?

 21.2.19: co.reddit/news.health/diet/omega-3/
high fat vs high carb diet improves omega-3 vs 6 ratio?:

. even when the diet's omega-6/omega-3 ratios are nearly the same,

the High fat diet group had a lower omega-6/omega-3 ratio

than the High carb diet group.