#CBD slows #bone remodeling in study of #osteoporosis

19.12.17: news.health/osteo/cbd/
GPR55 antagonist reduced mouse bone resorption:
12.23: summary:
. bone strength is maintained by remodeling,
where bone is removed by osteoclasts
to make way for new bone by osteoblasts.
. CBD appears to inhibit osteoclast function
and might be of use against osteoporosis;
but it also increases the number of osteoclasts,
so that if you ran out of CBD for a time,
the osteoclasts would be reactivated,
and there would be many more of them.
. as seen with the Bisphosphonates
the strategy of stopping resorption is flawed,
and should rarely be used [Dr.Ott]
because while the bone may remain dense,
the bone is not maintaining its strength.

. interestingly, this is another situation
where CBD and THC counteract each other.

. as a strategy to control bone loss,
a person's hormone function is key;
[J Osteoporos. 2010]
but, never take hormones orally,
or when modified in some patented way;
that is how Hormone Replacement Therapy
got a bad reputation.
. see Dr.Lee about progesterone cream
for bone health as summarized by Dr.Jo.

estrogen dominance as a risk of prostate cancer

19.12.15: health/hormonics/cancer#prostate/estrogen:
. Dr.Lee 2002 noted that prostate cancer is
one of the many diseases that can be
associated with estrogen dominance,
where there is too much estrogen
relative to progesterone.
. this is supported by a 2011 study
[ Expert Rev Endocrinol Metab. 2011:
Estrogen action and prostate cancer.]

. estradiol-17β has been classified as a carcinogen
by the International Agency for Research on Cancer [9–11],
primarily based on its association with
endometrial and breast carcinoma in women [12–15].

. young men have low estrogen,
moderate progesterone,
and 4 times as much testosterone (T);
but when aging they get more estrogenic activity
and the combination of T and estrogen
is what dramatically increases the risk
of prostate cancer.
At least in rats, testosterone alone
is necessary, but not sufficient,
for the development of prostate cancer.
It is only with the addition of estrogen
that cancer can be reliably induced.

#cancer #melatonin 10..40mg #health

19.12.8: health/hormonics/cancer/diet/
melatonin/10..40mg:
cancer recovery forum:
20mg to 25 mg of melatonin to combat cancer?
literature on melatonin and cancer:
Here are two reviews of many previous studies.

eye wear prescription data at home

2023.4.7: update: 19.12.8: aq.med/eyes/

generate eyewear prescription data at home
. one cool thing about at-home testing
of the eye's need for prescription lenses,
is knowing that there are eye wear providers
that accept your eye wear data
without proof that you have a prescription.
. this is valuable to me because
I have not felt comfortable with
the script that my eye doctor wrote:
the distance vision adjustment was
too strong, and the near vision was good for a foot away
when I would like to see what is in my lap.
. my first response was to wear various reading glasses
over my distance vision glasses;
but what I would prefer to do is
just order bifocals with my
preferred prescription strengths.
. I would still see an eye doctor to check for
diseases, such as glaucoma and AMD.

a doctor's path to reversing artery plaque from insulin resistance

19.12.2: tv.med/heart/a doctor's path to 
reversing artery plaque from insulin resistance:
Ford Brewer MD MPH Apr 18, 2017
How I Reversed 20 years of Arterial Plaque: 
Heart Attack Proofing?
. ACE inhibitors, like statins,
are designed for one thing
{lower blood pressure, lower cholesterol}
but they are actually most helpful because
they are reducing inflammation.
. he reduced high-glycemic carbs,
[noted in the captioning]
and because that lowers insulin
which improves blood lipids and pressure,
he was able to lower his dose of medications;
. he also used niacin, and ate salmon every day.