Y (male) chromosome degeneration

7.10: news.biol/Y (male) chromosome degeneration:

Professor of Human Genetics
at the University of Oxford since 1997,
Bryan Sykes, discussed his DNA research ,..
Sykes described his work on the
"Seven Daughters of Eve."
The Y (male) chromosome in general has been subject to
more degeneration and mutation than the X (female) chromosome,
and, he warned, if this continues
males might eventually become extinct .
. y-chromosome holding male-ness is decomposing;
we could move male genes to another chromosome,
or we could just clone without males .

[ Primate Y chromosomes, including in humans,
have degenerated so much
that primates will also evolve relatively soon,
new sex determination systems
in about 14 million years in humans.[7][25] ]

Criticism of the book and theory at Discover Magazine/
Jean M Says: June 1st, 2011 at 11:17 am: "(

Bryan Sykes heavily invested,
both academically and commercially,
in his vision of The Seven Daughters of Eve (2001)
– the matriarchs of the European population,
only one of whom (Jasmine i.e. mtDNA J)
he pictured as arriving from the Near East with farming.
The rest he saw as more ancient in Europe.
Unfortunately for Sykes, he was just plain wrong.
Now that aDNA researchers have better techniques
to guard against contamination,
and can test to a much higher degree of
resolution on the mtDNA tree,
the picture has turned completely around.
Two papers last year showed that
Neolithic people in Northern Europe
were completely unrelated to their Mesolithic predecessors,
who were overwhelmingly U4 and U5.
New papers attempting to set their own material in context
do not always reflect the latest discoveries.
There is often a long delay between
submission and publication of a paper.
This is the second paper which has attempted to
reconcile the old Sykes story with
what is emerging from Y-DNA,
not realizing that the Seven Daughters saga
has gone the way of the dodo.
Some of the mtDNA haplogroups found in this study
are indeed ancient in Europe – the U5 for sure.
But not the majority.
.
It no longer looks as though H1 and H3 were
spread from the Franco-Cantabrian refuge
either. See my blog post:
Franco-Cantabrian refuge for what? Not mtDNA H1, H3.)

[. that post is not archived, but there is
a follow up at eupedia.com .]

forums for bizarre ideas

7.8: news.adds/forums for bizarre ideas:
. forums for exploring bizarre ideas,
found while googling for aspirin-melatonin interactions .
AboveTopSecret.com:

AboveTopSecret.com is the Internet's largest and most popular
discussion board community dedicated to
the intelligent exchange of ideas and debate
on a wide range of "alternative topics"
such as conspiracies, UFO's, paranormal, secret societies,
political scandals, new world order, terrorism,
and dozens of related topics with
a diverse mix of users from all over the world.

unexplained-mysteries.com:

A to Z of the unexplained, paranormal phenomena, discussion forum,
sightings database, search engine and all the latest news
on everything unexplained.

mech.pencil with less lead wasted

8.13: proj.cyb`gear/mech.pencil with less lead wasted:
. try sawing off tip of a forte pentel a55
and found that the unit is right at the chuck tip,
going below that
clears a lip that holds back the ring
that holds the chuck closed .

. the big win of the whole experiment
is the twist erase-III QE515-C:

conquering imac brightness

8.6: proj.cyb`gear/mac`shades/
combined shade&blue-blocker/test:
. make new imac glasses with orange uv shades
taped to sunglasses
-- depressing in room but just right for mac .

8.7: proj.cyb`gear/mac`shades/
string to raise nose bridge:
. add bridge to mac shades to get more ventilation
and reduce fog .

8.10: proj.cyb`gear/mac`shades:
. tape isn't holding up? get help by
tucking the lenses under the nose bridge string .

8.18: proj.cyb`gear/mac`shades/
drill holes for holding shades on shades:
. use the aluminum wire
in the smallest holes my drill will give .
. like a staple but twisted once too .

making room for a used leather couch

08.25 apt`gear couch

8.24: apt`gear/couch/explore reuse:
. my neighbors tossed a great leather couch
so I took it home with my dolly,
but there's no space in the living room
unless I can move out the couch currently there .
. the only way to get it down the hallway,
is to cut off its absurdly tall arms
(they are as high as the back of the couch!);
but how to remove the upholstry on the couch
without ripping all the fabric up?

an app that alerts you to drone strikes

8.30: news.cyb/dev.iOS/
an app that alerts you to drone strikes:

. npr just said that the Apple app store
recently disallowed an app that would
ring you for each drone strike?

. I can understand why Apple would make such a stand;
they shouldn't be put in the position of
ok'ing another's political speech
in what amounts to their work place .
. would you go on about drones at your workplace ?
some might think that unpatriotic
and some might agree drones are not right
but not want their chain pulled during work .
. we all have to get along at work;
there is plenty of time for free speech afterwards .

. we need a generic version of the same thing:
an app that interfaces a news site
where you can get rings for
your personal search results;
eg, it could be integrated with google's alert service,
which sends emails to you
whenever some search of interest to you
comes up with another hit .
. in this integration,
it could ring your idevice instead of emailing you .

carnitine saves bone when thyroid acts up

8.5: web.health/osteo/
carnitine saves bone when thyroid acts up
. high T4 and high TSH (thyroid stimulating hormone)
results in lower bone density .
. however it may not be the thyroid directly;
rather,
high thyroid causes high cortisol
and high cortisol causes osteoporosis .
. when hyper-thyroid women were given carnitine
they had better bone density;
and it's known that after carnitine usage,
thyroid hormones can't get to their target;
but some thought this link was not direct:
rather, they theorized that
because carnitine may also lower cortisol
it could be the cortisol reduction
that has carnitine saving bone .
... however, I couldn't find anything on
carnitine's lowering of cortisol,
except that at huge doses it can raise cortisol;
so, I'm theorizing that the reason for
carnitine helping bone mass,
is that it prevents high thyroid activity
and then normalizing thyroid also normalizes cortisol,
which then normalizes bone density .
. any hyperthyroid osteoporosis with normal cortisol?
. Thyroid hormone directly stimulates bone resorption
in organ culture .
. hyper-thyroidism is associated with
accelerated bone remodeling;
conversely,
hypo-thyroidism is associated with
bones that are denser but not stronger
suggesting a retarded resorption
(bone building adds the density
but matched breakdown is needed for strength).