Dr.Sinclair xenohormesis in contrast to hormesis

20.10.15: news.health/diet/

Dr.Sinclair`xenohormesis in contrast to hormesis:

Dr.Sinclair 2020:

. hormesis means the use of stressors

to activate our longevity defenses;

such as exercise, intermittent fasting, 

low protein diets, and being hot or cold:

see the paper:

"The 'Metabolic Winter' Hypothesis: 

A Cause of the Current Epidemics of 

Obesity and Cardiometabolic Disease"

METABOLIC SYNDROME AND RELATED DISORDERS 2014

which suggests that we have benefited from

a life without air conditioning.

[ that paper also clarifies 

what the author says about xenohormesis

in contrast to hormesis:

"(

. a reduction in calories by 30%–40% triggers a 

network of genes that evolved to protect organisms

during times of food scarcity (i.e., "longevity" genes). 

This "longevity survival network" includes 

insulin/insulin-like growth factor-1 (IGF-1) signaling, 

mammalian target of rapamycin (mTOR), 

AMPactivated protein kinase (AMPK), 

and the seven sirtuins (SIRT1–7), 

a family of cellular energetics and defense enzymes.44–46 

In fact, sirtuin-activating compounds (STACs),

such as resveratrol and fisetin, 

and other calorie restriction mimetics, such as metformin, 

are thought to derive the majority of their health benefits

not from antioxidant properties 

nor by inducing a cellular damage response (hormesis),

but rather from interacting with conserved regions in enzymes

that have evolved to sense molecules in the environment.47,48 

The "xenohormesis hypothesis" suggests that 

STACs act as an advance warning generated by plants

in times of stressful environmental conditions,

and that these stress-signaling molecules may coordinate

sirtuin-mediated defenses across species.49–52

)-'Metabolic Winter' Hypothesis.

]

. some supplements can be helpful by

being hormesis-mimicking; such as resveratrol, 

and more recently in the news: NAD boosters;

but metformin is controversial; most recently

it inhibits your ability to build muscle

with resistance training.

. similar to how certain stresses make us healthier,

plants under stress can make more of the 

health-promoting "Xenohormetic" nutraceuticals.

When plants are stressed with too much sunlight, 

they often add extra color with anthocyanins

and they are produced not only by radiation damage

but drought, adverse temperatures, nutrient restriction, 

pathogens, and wounding. 

. the wines at "Dry Farm Wines" (and Stressed Vines)

especially the pinot noir, have higher levels resveratrol 

because they are stressed;

[ for instance, they don't use irrigation,

and they do use organic farming

which can add fungal stresses.]

dryfarmwines test their wines:

"By law, wine is not required to have a contents label

on the bottle. This is based on a old agreement 

between the wine lobby and the US government. 

As one of the only major food groups 

without a content label, consumers are

left in the dark about what is in their wine.

Since there are 76 legal additives approved for use

in winemaking by the government,"

testing can ensure that a wine minimizes additives.