#healthcare #fluoride Dr. David Kennedy

19.6.2: pol/healthcare/fluoride/Dr. David Kennedy:
6.3: summary:
. more bad news about fluoride
being a hormone disruptor;
I live in Tucson which doesn't fluoridate,
so my main source has been tea
which is a fluoride accumulator,
and comes mainly from China
where there is a lot of fluoride pollution
from burning coal.
. fluoride is known to affect thyroid
and very high levels of it may reduce
testosterone levels.

. heard Dr. David Kennedy on the radio:
with Martie Whittekin (Healthy By Nature)
[Tucson, AZ, KGMS 940 AM – Sunday 1 pm]
. fluoride is an endocrine disruptor
by affecting g-protein function.
fluoride increases brain aluminum.
Dr. David Kennedy has a book:
David Kennedy 1996`How to Save Your Teeth:
Toxic-Free Preventive Dentistry.
--
. that book has cult-classic pricing on amazon
but cheap pdf's are sold by iaomt.org.

iaomt introduces Dr. David Kennedy:
. lectured internationally
to dentists and professionals on
preventive and restorative dentistry
and on the hazards of mercury and fluoride,
and is a past president of the
International Academy of Oral Medicine and Toxicology.

about IAOMT:
Internat Academy of Oral Medicine and Toxicology
is a global network of dentists,
health professionals, and scientists
who research the biocompatibility of dental products,
including the risks of mercury fillings, fluoride,
root canals, and jawbone osteonecrosis.
has summary of dentistry done right.

web: g proteins:

Heterotrimeric G proteins located within the cell
are activated by G protein-coupled receptors (GPCRs)
that span the cell membrane.[3]
Signaling molecules bind to a domain of the GPCR
located outside the cell,
and an intracellular GPCR domain then in turn activates
a particular G protein.
The G protein activates a cascade of further signaling events
that finally results in a change in cell function.
G protein-coupled receptor and G proteins working together
transmit signals from many hormones,
neurotransmitters, and other signaling factors.
G proteins regulate metabolic enzymes,
ion channels, transporter proteins,
and other parts of the cell machinery,
controlling transcription, motility, contractility, and secretion,
which in turn regulate diverse systemic functions
such as embryonic development,
learning and memory, and homeostasis.
G proteins are important signal transducing molecules in cells.
"Malfunction of GPCR signaling pathways
are involved in many diseases, such as
diabetes, blindness, allergies, depression,
cardiovascular defects, and certain forms of cancer.
It is estimated that about 30% of the
modern drugs' cellular targets are GPCRs." [13]

Whereas G proteins are activated by
G protein-coupled receptors,
they are inactivated by RGS proteins
(for "Regulator of G protein signalling").

G#αs activates the cAMP-dependent pathway
by stimulating the production of
cyclic AMP (cAMP) from ATP.
This is accomplished by direct stimulation of
the membrane-associated enzyme
adenylate cyclase.
cAMP can then act as a second messenger
that goes on to interact with and activate
protein kinase A (PKA).
PKA can phosphorylate a myriad downstream targets.
The cAMP-dependent pathway is used as a
signal transduction pathway
for many hormones including:
ADH – Promotes water retention by the kidneys (created by the V2 cells of the posterior pituitary)
GHRH – Stimulates the synthesis and release of GH (somatotroph cells of the anterior pituitary)
GHIH – Inhibits the synthesis and release of GH (somatotroph cells of anterior pituitary)
CRH – Stimulates the synthesis and release of ACTH (anterior pituitary)
ACTH – Stimulates the synthesis and release of cortisol (zona fasiculata of the adrenal cortex in the adrenal glands)
TSH – Stimulates the synthesis and release of a majority of T4 (thyroid gland)
LH – Stimulates follicular maturation and ovulation in women; or testosterone production and spermatogenesis in men
FSH – Stimulates follicular development in women; or spermatogenesis in men
PTH – Increases blood calcium levels. This is accomplished via the Parathyroid hormone 1 receptor (PTH1) in the kidneys and bones, or via the Parathyroid hormone 2 receptor (PTH2) in the central nervous system and brain, as well as the bones and kidneys.
Calcitonin – Decreases blood calcium levels (via the calcitonin receptor in the intestines, bones, kidneys, and brain)
Glucagon – Stimulates glycogen breakdown in the liver
hCG – Promotes cellular differentiation, and is potentially involved in apoptosis.[21]
Epinephrine – released by the adrenal medulla during the fasting state, when body is under metabolic duress. It stimulates glycogenolysis, in addition to the actions of glucagon.

fluoride endocrine disruption/thyroid:

Scientific American 2008:
summary:
Dan Fagin is award-wining environmental reporter
and Director of New York University's
Science, Health and Environmental Reporting Program.
Some researchers wonder whether the
1 mg/L added into drinking water is too much.
. a National Research Council (NRC) committee
"concluded that fluoride can subtly
alter endocrine function,
especially in the thyroid".
Fagin quotes John Doull, professor emeritus
of pharmacology and toxicology
at the University of Kansas Medical Center,
who chaired the NRC committee thusly,
"The thyroid changes do worry me."

national tox program 2015:
. Water fluoridation represents 30% to 70%
of an individual’s total exposure.
Fluoride has been nominated to NTP for
evaluation of non-cancer health outcomes.
Fluoride, CAS 7681-49-4
At the NTP Board of Scientific Counselors
meeting on December 2, 2015,
OHAT proposed conducting separate analyses of
fluoride exposure and endocrine health effects.
OHAT will examine the extent of available literature
to inform NTP’s decision on whether or not
to propose conducting a formal
assessment of the scientific literature
to reach conclusions regarding whether
exposure to fluoride is a hazard for
non-thyroid endocrine health.

web: fluoride and aluminum:

thyroidnation's SVIREL SONG:
. the type of fluorides added to water supplies
are waste products of the aluminum,
and now mostly the phosphate (fertilizer) industries.
The EPA has classified these as toxins:
fluorosilicate acid, sodium silicofluoride,
and sodium fluoride.
The fluoride obtained from industrial waste
and added to water supplies
is also already contaminated
with lead, aluminum, and cadmium.
. it increases the potency of other toxic materials;
eg, it can carry aluminum across the blood brain barrier.
-- possibly related to
lower IQ’s and Alzheimer’s.
. According to Smith and Leverton, Univ AZ,
[Ind. Eng. Chem 1934
Comparative Toxicity of Fluorine Compounds.]
industrial waste sodium fluorides are
85 times more toxic than
naturally occurring calcium fluoride.

fluoride endocrine disruption/testosterone:

Ali Kuoppala:
. he summarizes the following studies.

Environmental Research 2003
Fluoride-induced disruption of reproductive hormones in men.
a fluoride exposure of 3–27 mg/day
induces a subclinical reproductive effect
that can be explained by a fluoride-induced
toxic effect in both Sertoli cells and gonadotrophs.
. 3–27 mg/day (high-fluoride-exposed group—HFEG).
2–13 mg/day (low-fluoride-exposed group—LFEG).
Urinary fluoride levels, semen parameters,
and reproductive hormones in serum
A significant increase in FSH (P less 0.05)
and a reduction of
inhibin-B, free testosterone, and prolactin
in serum (P less 0.05) were noticed in the HFEG.
When HFEG was compared to LFEG,
a decreased sensitivity was found
in the FSH response to inhibin-B (P 0.05).
A significant negative partial correlation
was observed between urinary fluoride
and serum levels of inhibin-B (r=−0.333, P=0.028)
in LFEG. Furthermore, a significant partial correlation
was observed between a chronic exposure index for fluoride
and the serum concentrations of
inhibin-B (r=−0.163, P=0.037) in HFEG.

Naturwissenschaften 2007
Suppression of male reproduction in rats.
. exposure to NaF during gestation and lactation
affects male reproduction in adult rats by
decreasing spermatogenesis and steroidogenesis.
. a dose of 4.5 and 9.0 ppm via drinking water.
The activity levels of testicular
steroidogenic marker enzymes
(3β hydroxysteroid dehydrogenase
and 17β hydroxysteroid dehydrogenase)
were significantly decreased in experimental animals
indicating decreased steroidogenesis.
The serum testosterone,
follicle stimulating hormone
and luteinizing hormone levels
were also significantly altered in experimental animals.
[includes refs]

Chinese J Endemiology 1994
Influence of fluoride on the contents of
testosterone and cholesterol.
. the level of serum testosterone
had the tendency of decreasing
with time in rats drinking
100mg/L, 200mg/L fluoride.
. coal burning can be
a major source of fluoride in China;
[most of our tea comes from coal-burning China,
and tea is a fluoride accumulator]

Chinese J Endemiology 2003
Experimental study on effect of fluoride
on reproductive system of male rats.
. Sodium fluoride was administered to male rats
with drinking water (150 mg/L) for 10 weeks.
. the sperm count, the rate of sperm mobility,
as well as the levels of serum testosterone (T)
and luteinizing hormone (LH),
were suppressed by fluoride.
While the rate of sperm aberration was elevated.
The differences between two groups were significant ( P 0.05).

Reproductive Toxicology 2002:
Testicular toxicity in sodium fluoride treated rats:
association with oxidative stress.
Sodium fluoride treatment at 20 mg/kg/day for 29 days
by oral gavage resulted in significant diminution in
the relative wet weight of the testis, prostate,
and seminal vesicle without alteration
in the body weight gain.
Testicular Δ5,3β-hydroxysteroid dehydrogenase (HSD)
and 17β-HSD activities were decreased
significantly along with significant diminution
in plasma levels of testosterone
in the fluoride-exposed group compared to the control.
Epididymal sperm count was decreased
significantly in the fluoride-treated group
and qualitative examination of testicular sections
revealed fewer mature luminal spermatozoa
in comparison to the control.
The seminiferous tubules were dilated in treated animals.
Fluoride treatment was associated with
oxidative stress as indicated by
an increased level of conjugated dienes
in the testis, epididymis, and epididymal sperm pellet
with respect to control.
Peroxidase and catalase activities
in the sperm pellet were
decreased significantly in comparison to the control.

Toxicology Mechanisms and Methods 2005
Induction of Oxidative Stress on
Reproductive and Metabolic Organs
in Sodium Fluoride-Treated Male Albino Rats:
Protective Effect of Testosterone
and Vitamin E Coadministration.
. fluoride at the dose noted in
drinking water in contaminated areas
(20 mg/kg body weight/day)
may induce oxidative stress in
reproductive and metabolic organs.
. Coadministration of testosterone
40 μg/100 g body weight/alternate day,
3 hours after fluoride treatment,
resulted in a significant protection of
catalase and peroxidase, which are
important antioxidant enzymes in
testicular tissue, sperm pellet,
prostate, and epididymis.
. fluoride elevated
malondialdehyde and conjugated dienes,
indicators of oxidative stress,
which were resettled toward the control level
after testosterone coadministration.
. oxidative stress parameters in
reproductive organs and metabolic organs,
were recovered with vitamin E
at the dose of 20 mg/100 g body weight.

Research report Fluoride 2008
Effects of NaF on androgen receptor
expression in male mice.
sodium fluoride (NaF)
androgen receptor (AR).
50, 100, 200, and 300 mg NaF
per L drinking water.
. expressions of AR protein decreased significantly
in the 200 and 300 mg NaF/L groups (p less 0.05).
. culturing primary Sertoli cells from
immature mice with different concentrations of fluoride
(10-6, 10-5, 10-4, and 10-3 mol/L) for 48 hr:
a significant F-induced decline
in the AR mRNA level.
. NaF decreases in AR protein
and gene expression in the testis
is associated with impairment of
reproductive functions.
. It is well known that toxic effects of fluoride
are seen in diminished sperm quality
and concentrations of testosterone in various animals.
[ Susheela AK, Jethanandani P.
Circulating testosterone levels in skeletal fluorosis patients.
J Toxicol Clin Toxicol 1996;34(2):183-9.
Zhang JH, Liang C, Ma JJ, Niu RY, Wang JD.
Effects of sodium fluoride and sulfur dioxide on
sperm motility and serum testosterone in male rats.
Fluoride 2006;39(2):126-31.
Huang C, Niu RY, Wang JD.
Toxic effects of sodium fluoride
on reproductive function in male mice.
Fluoride 2007;40(3):162-8
Chinoy NJ, Narayana MV, Sequeira E, Joshi SM, Barot JM, Purohit RM, et al.
Studies on effects of fluoride in 36 villages
of Mehsana district, North Gujarat.
Fluoride 1992;25(3):101-10.
Zakrzewska H, Udała J, Błaszczyk B.
In vitro influence of sodium fluoride
on ram semen quality and enzyme activities.
Fluoride 2002;35(3):153-60.]

other effects:

Toxicol Lett. 2009:
biologically relevant concentrations of fluoride
are capable of increasing cell migration in tumour cells,
suggesting that exposure to fluoride
could stimulate tumour invasion.

Caries Res 2001:
Fluoride Deposition in the Aged Human Pineal Gland
. positive correlation between
pineal F(fluoride) and pineal
Ca (r = 0.73, p less 0.02).
By old age, the pineal gland has
readily accumulated F
and its F/Ca ratio is higher than bone.

Calcified Tissue Research 1974
Optical, physical and chemical properties
of pineal gland calcifications.
. calcospherulite textures have been observed
which have a granular substructure
made up of apatite crystals;
appear to be a carbonate-containing hydroxyapatite,
mineralogically similar to enamel.

Paul Joseph Watson & Matt Ryan 2010:
. see Christopher Bryson 2006`The Fluoride Deception
[. one of the great secret narratives
of the industrial era:
how a grim workplace poison and the most
damaging environmental pollutant of the cold war
was added to our drinking water and toothpaste.
. it documents a powerful connection
between big corporations, the U.S. military,
and the historic reassurances of fluoride safety
provided by the nation’s public health establishment.
. supported by two hundred pages of source notes,
years of investigative reporting,
scores of scientist interviews,
and archival research in places such as
the newly opened files of the Manhattan Project
and the Atomic Energy Commission.]
--
includes dozens of peer-reviewed studies.
showing that sodium fluoride
leads to a multitude of serious health problems.
This fact has been covered up by a
collusion of government and industry
who have reaped financial windfalls
[cheaply disposing of industrial waste].

In Germany, Belgium and Luxembourg
fluoridation of water was rejected because
it was classified as compulsive medication
against the subject’s will
and therefore violated fundamental human rights.

American Dental Association (ADA) 2006:
avoid giving babies fluoridated water.

– Sources of fluoride include:
pesticides, pharmaceuticals,
processed foods made with fluoridated water,
and tea.