2009-12-27

Preventive approach to Alzheimer's disease

8.27: news.health/Preventive approach to Alzheimer's disease:

A study from University of California in Los Angeles
used immune cells to help identify a suspected indicator of Alzheimer's disease.
By testing the ability of immune cells in the blood
to absorb the peptide amyloid beta,
researchers moved toward developing a blood test
which can gauge a person's risk of developing Alzheimer's.
Patients in the study with Alzheimer's disease demonstrated
poor uptake of amyloid beta,
while participants without the disease showed high uptake.
The results conclude that if the immune system is not adequately
clearing amyloid beta, there is risk of developing Alzheimer's.
MP Biomedicals LLC of Orange County has a contract to commercialize the
technology developed by UCLA,
creating a diagnostic blood test for screening for Alzheimer's disease.
[12.27:
. I believe there are other results showing
that on the other side of the equation
a hormonic diet (low-glycemic load with high legume)
can help the weak immune system
by making less plaque needing removal . ]

11.6: news.hormonics/alz'/more evidence against high-carb lifestyles:
They used a genetic mouse model that
develops Alzheimer's-like symptoms in adulthood,
and over a 25 week period supplemented the
regular, balanced diet of half the animals
with 10% sugar water.
Afterwards, they compared the metabolism,
memory skills (by means of various mazes)
and brain composition
of the regular and sugar-fed mice.
The sugar-fed mice gained about 17% more weight
than controls, had higher cholesterol levels,
and developed insulin resistance.
These mice also had worse learning and memory retention
and their brains contained over twice as many
amyloid plaque deposits,
an anatomical hallmark of Alzheimer's .

. “Diet-induced hyperhomocysteinemia
increases Amyloid-beta formation and deposition
in a mouse model of Alzheimer’s disease,”
-- journal: Current Alzheimer Research.
“The data from previous studies show — even in humans —
when the level of homocysteine in the blood is high,
there is a higher risk of developing dementia.
We hypothesized that high levels of homocysteine
in an animal model of Alzheimer’s
would accelerate the disease” .
. there are apparently 2 factors controling homocysteine levels:
a high-methionine diet,
and maintaining a biochemistry that can
prevent methionine from lingering in its intermediary,
homocysteine form .
. this is yet another reason why high-quality protein
must be drip-fed,
and thus why the best way to get it is from beans .
. other factors needed for minimizing the intermediary
is b-6, and perhaps some other b-vitamins .
. tmg or dmg might also help homocysteine .

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