inflammation syndrome and colon cancer

11.16: health/colon cancer

summary:
. inflammation syndrome seems to be a key;
foods tend affect risk in proportion to their inflammation index:
grain-fed meats, high-glycemic fruits
are inflammatory,
while wild fish and low-glycemic veg's
are anti-inflammatory
. aspirin too reduces both risk and inflammation,
though the dose that might be useful
might also be kidney problems .


inflammation syndrome

. conditions that contributes to inflammation of the colon can lead to cancer.
Diabetes Can Lead to Colon Cancer
According to WebMD, people with diabetes have a 30-40%
increased risk of colon cancer.
So it's important to maintain a normal weight
and to lose weight if an individual is obese.

risk-factors-colorectal-cancer

. a person who already has had colorectal cancer
may develop the disease a second time.
. those who have chronic inflammatory conditions of the colon,
such as ulcerative colitis or Crohn's disease,
also are at higher risk of developing colorectal cancer.
# Diet. A diet high in fat and calories and low in fiber

may be linked to a greater risk of developing colorectal cancer.
# Lifestyle factors.

You may be at increased risk for developing colorectal cancer if you

drink alcohol, smoke, don't get enough exercise,

and if you are overweight.
# Diabetes.

People with diabetes have a 30-40% increased risk

of developing colon cancer.

Cancer epidemiology, biomarkers & prevention

2006, vol. 15, no12, pp. 2391-2397

Obesity and diabetes are established risk factors
for colorectal cancer but have mainly been assessed independently.
There are few data about whether the metabolic syndrome,
which refers to a clustering of cardiovascular disease risk factors
thought to be related to insulin resistance,
including obesity, type 2 diabetes, hyperlipidemia, and hypertension,
is associated with colorectal cancer risk.
Out of the markers of the metabolic syndrome assessed,
overweight and diabetes are risk factors for colorectal cancer,
whereas, in contrast to their role in cardiovascular disease,
elevated blood pressure and hypercholesterolemia are not.

Smoking:

It has been shown that smokers have a 30-40% greater chance
of acquiring colon cancer than non- smokers.

http://www.aicr.org.uk/ColonCancerFAQs.stm

Obesity can increase the risk of cancer of the colon by up to one third.
High alcohol intake is also known to increase the risk of colon cancer.
However, some common drugs, such as aspirin-like painkillers
and hormone replacement therapy,
are known to reduce the risk of bowel cancer.
Low fat, high fibre diets appear to carry a lower risk.
Greater consumption of vegetables and fruit has also been shown to reduce the risk.
Increased consumption of red meat and processed meat
has been linked to a higher risk.
By comparison, eating fish does not appear to be a risk factor.
Some evidence suggests that certain dietary supplements,
such as calcium, selenium and, possibly, folic acid
can reduce the risk.

obesity from eating for stress may be another link
More Evidence Stress and Cancer are Linked Posted by: Dr. Mercola
Cancer Research November 1, 2006; 66(21): 10357-10364
Science Daily November 3, 2006

Stress

Norepinephrine, a hormone produced during periods of stress, may increase the growth rate of cancer.

The norepinephrine can stimulate tumor cells to produce two compounds (matrix metalloproteinases called MMP-2 and MMP-9) that break down the tissue around the tumor cells and allow the cells to more easily move into the bloodstream.

Once there, they can travel to other organs and tissues and form additional tumors, a process called metastasis.

Norepinephrine may also stimulate the tumor cells to release a chemical (vascular endothelial growth factor, or VEGF) that can aid in the growth of the blood vessels that feed cancer cells. This can increase the growth and spread of the cancer.
Researchers traced the harmful effect of norepinephrine after applying it to cancer cell lines used to study nasopharyngeal carcinoma (NPC), an incurable head and neck cancer associated most frequently with those of Chinese descent.